Zobrazeno 1 - 10
of 175
pro vyhledávání: '"George P, Daston"'
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
The objective of this work was to use transcriptional profiling to assess the biological activity of structurally related chemicals to define their biological similarity and with that, substantiate the validity of a read-across approach usable in ris
Externí odkaz:
https://doaj.org/article/fe8f70441c9949b090f1103fca787eaa
Autor:
Aldert H. Piersma, Nancy C. Baker, George P. Daston, Burkhard Flick, Michio Fujiwara, Thomas B. Knudsen, Horst Spielmann, Noriyuki Suzuki, Katya Tsaioun, Hajime Kojima
Publikováno v:
Current Research in Toxicology, Vol 3, Iss , Pp 100074- (2022)
This manuscript provides a review focused on embryonic stem cell-based models and their place within the landscape of alternative developmental toxicity assays. Against the background of the principles of developmental toxicology, the wide diversity
Externí odkaz:
https://doaj.org/article/0e3fcdf035aa43749c37ad3ba069d7ff
Autor:
K Nadira, De Abrew, Ted, Natoli, Cathy C, Lester, Xiaohong, Wang, Mahmoud, Shobair, Arvind, Subramanian, George P, Daston
Publikováno v:
Toxicological Sciences. 190:227-241
Butylated hydroxytoluene (BHT) is a synthetic antioxidant widely used in many industrial sectors. BHT is a well-studied compound for which there are many favorable regulatory decisions. However, a recent opinion by the French Agency for Food, Environ
Autor:
Shengde Wu, Corie Ellison, Jorge Naciff, Michael Karb, Cindy Obringer, Gang Yan, Yuqing Shan, Alex Smith, Xiaohong Wang, George P Daston
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology.
The purpose of this study was to use chemical similarity evaluations, transcriptional profiling, in vitro toxicokinetic data, and physiologically based pharmacokinetic (PBPK) models to support read-across for a series of branched carboxylic acids usi
Autor:
Anne H. Chappelle, Kimberly W. White, Donna L. Mendrick, Linda S. Birnbaum, Laurie C. Haws, Suzanne Fitzpatrick, K. Nadira De Abrew, Katerine S. Saili, Jill A Franzosa, Thomas B. Knudsen, Susan Y. Euling, Alison Elder, George P. Daston, Nicole Kleinstreuer, Alexandra Turley, Ruthann A. Rudel, Dana C. Dolinoy, Elaine M. Faustman, Germaine M. Buck Louis, Thaddeus T. Schug, Todd J. Zurlinden, Robyn L Tanguay, Barbara A. Wetmore, Derik E. Haggard, Kristi Pullen Fedinick
Publikováno v:
Toxicol Sci
FutureTox IV, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2018. Building upon FutureTox I, II, and III, this conference focused on the latest science and technology for in vitro profiling and in silico m
Autor:
Harm J. Heusinkveld, Aldert H. Piersma, Yvonne C.M. Staal, George P. Daston, Nancy C. Baker, Thomas B. Knudsen
Publikováno v:
Reprod Toxicol
In recent years, the development and implementation of animal-free approaches to chemical and pharmaceutical hazard and risk assessment has taken off. Alternative approaches are being developed starting from the perspective of human biology and physi
Autor:
F. E. Freeberg, George P. Daston
Publikováno v:
Dermal and Ocular Toxicology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91f58c165435272a51559f83df50accc
https://doi.org/10.1201/9781003069126-18
https://doi.org/10.1201/9781003069126-18
Autor:
George P. Daston, Lorna Ewart, Randolph S. Ashton, Catherine Mahony, Irene Manou, Barbara Birk, Sebastian Maurer-Stroh, Mark T. D. Cronin, Ruth Roberts, Tom Cull, Zvonar Zvonimir, Evita Vandenbossche, Boris P. Müller, Thomas Steger-Hartmann, Pär Nordlund, Luigi Margiotta-Casaluci, Maurice Whelan, Mathieu Vinken, Alan R. Boobis, Mark R. Viant, Thomas B. Knudsen
© 2020 The Authors The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a ‘Blue Sky Workshop’ on new ideas for non-animal approaches to predict repeated-dose systemic toxicity. The aim of the Workshop was to form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95fa1135aa80ac55d52698644e34b67
https://doi.org/10.1016/j.yrtph.2020.104668
https://doi.org/10.1016/j.yrtph.2020.104668
Autor:
George P. Daston
Publikováno v:
Molecular and Cellular Methods in Developmental Toxicology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6feb548349ff458e99c8ef78f2af06eb
https://doi.org/10.1201/9780429187193-1
https://doi.org/10.1201/9780429187193-1