Zobrazeno 1 - 10
of 12
pro vyhledávání: '"George Oshiro"'
Autor:
George Oshiro, John F. Howes
Publikováno v:
Nitobe Inazô ISBN: 9780429047213
Nitobe Inazô
Nitobe Inazô
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e89794693bbd575b1a4d3abdd215491f
https://doi.org/10.4324/9780429047213-2
https://doi.org/10.4324/9780429047213-2
Autor:
George Oshiro
Publikováno v:
Nitobe Inazô ISBN: 9780429047213
Nitobe Inazô
Nitobe Inazô
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d05e810a0034421b92a9e8cbd8a17949
https://doi.org/10.4324/9780429047213-17
https://doi.org/10.4324/9780429047213-17
Autor:
N. Halaka, Thomas M. Argentieri, D. Zebick, C. Havens, N J Lodge, Richard M. Soll, Thomas J. Colatsky, Paul Jeffrey Dollings, R.J. McCaully, George Oshiro, N.W. Norton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:769-773
N-sulfonamides of the benzopyran-related class of potassium channel openers were found to inhibit KCl-induced contractions of smooth muscle preparations (rat aorta or bladder preparations) in a glyburide insensitive manner or to augment contractions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a684e6f0724049254fe827bd7a0edd69
https://doi.org/10.1016/s0960-894x(01)80198-0
https://doi.org/10.1016/s0960-894x(01)80198-0
Autor:
D. Hartupee, John D. McCallum, V. White, William A. Kinney, A. Russo, R.J. McCaully, J. Dinish, George Oshiro, Richard M. Soll, C.H. Park, John Primeau, A. Wojdan, L. Garrick, Thomas J. Colatsky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:757-760
Application of the novel carboxylic acid bioisostere 3-hydroxy-3-cyclobutene-1,2-dione to the design of a potent, non-peptidic, non-tetrazole angiotensin II antagonist 4 is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb88c19ba1545d818804340dcc334f4d
https://doi.org/10.1016/s0960-894x(01)81269-5
https://doi.org/10.1016/s0960-894x(01)81269-5
Autor:
Betsy L. Joslyn, A. Wojdan, Paul Jeffrey Dollings, Terrence M. Dolak, David D. Deininger, Mary Ellen Morin, Richard M. Soll, Dominick Anthony Quagliato, Chris Bohan, George Oshiro, Sung J. Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:591-594
A series of benzopyran-related potassium channel activators were prepared and evaluated at the calculated ED 30 dose in the spontaneously hypertensive rat. The duration of the blood pressure lowering effect was found to be related to the lipophilicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84bf3d8f94803de94419b6fad768427c
https://doi.org/10.1016/s0960-894x(01)81157-4
https://doi.org/10.1016/s0960-894x(01)81157-4
Autor:
Jean E. Sealey, Rodney W. Lappe, Tomas Lenz, Cynthia Carilli, George Oshiro, John D. Baxter, John H. Laragh
Publikováno v:
American Journal of Hypertension. 3:257-261
Prorenin, the biosynthetic precursor of active renin, is present in high concentrations in the kidney and reproductive organs. We have proposed that prorenin may be the vehicle of local renin systems, separating the functions of circulating and tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf0732b82cc8fbd7611be38f6b3a397
https://doi.org/10.1093/ajh/3.4.257
https://doi.org/10.1093/ajh/3.4.257
Synthèse et évaluation pharmacologique d'analogues indoliques de l'antagoniste du calcium, vérapamil
Autor:
Andre A. Asselin, James A Parks, George Oshiro, Thomas J. Rimele, D. Grimes, A. Wojdan, Richard J. Heaslip, Richard M. Soll
Publikováno v:
European Journal of Medicinal Chemistry. 25:191-196
Based on the notion of a bioisosteric relationship between catechol-(phenol-) and indole-amines, indole congeners of the calcium entry blocker verapamil were synthesized and examined as calcium entry blockers and as alpha1-adrenoceptor antagonists in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478cfdc008138287e854f742f8f227ff
https://doi.org/10.1016/0223-5234(90)90028-2
https://doi.org/10.1016/0223-5234(90)90028-2
Autor:
John D. McCallum, Jan M. Kitzen, Charlotte Harvey, Mary Ellen Morin, George Oshiro, Thomas J. Colatsky
Publikováno v:
Pharmacology. 45(2)
The cardioprotective effects of the K channel activator drugs celikalim (WAY-120,491) and cromakalim were studied in a canine model of myocardial infarction consisting of 90 min of ischemia and 5 h of reperfusion. Intracoronary infusion of cromakalim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db385af6d7a35949ea4a3b0550ceb70
https://pubmed.ncbi.nlm.nih.gov/1523216
https://pubmed.ncbi.nlm.nih.gov/1523216
Publikováno v:
Journal of Medicinal Chemistry. 30:388-394
Simplifications and modifications of the vincamine molecule led to the discovery of antihypertensive 1,2,3,4,4a,5,6,12b-octahydro-12-methylpyrazino[2',3':3,4]pyr ido[1,2-a] indoles. Stereoselective syntheses of both 4a,12b-cis and 4a,12b-trans isomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6e914fce5f545c3121e9255499c1b1
https://doi.org/10.1021/jm00385a022
https://doi.org/10.1021/jm00385a022
Autor:
Thomas J. Rimele, Andre A. Asselin, A. Wojdan, D. Grimes, Danilo A. Crosilla, George Oshiro, Richard J. Heaslip, C. C. Shaw, Leslie G. Humber
Publikováno v:
Journal of Medicinal Chemistry. 29:1009-1015
The synthesis of 5-[hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]-1H-indole-7- carboxamide, 5, a pyrrolo analogue of labetalol, is described. Compound 5 was found to reduce blood pressure in spontaneously hypertensive rats with an ED50 of 5 mg/kg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efecc4e140a009f6b6fe389a32bc7e97
https://doi.org/10.1021/jm00156a019
https://doi.org/10.1021/jm00156a019