Zobrazeno 1 - 10
of 50
pro vyhledávání: '"George Orphanides"'
Autor:
Lorraine Mooney, George Orphanides, Victoria Pollard, Cath Eberlein, Richard Bethell, Theonie Georgiou, Jane Kendrew, Tiffany Daniels
Publikováno v:
Cancer Research. 80:2887-2887
Phenotyping of AML patient samples shows that CD33, a myeloid cell marker, and CD7, a lymphoid cell marker, are specifically co-expressed in 25% of AML cases. Development of a bispecific antibody drug conjugate (ADC) dependent on co-expression of CD7
Autor:
Paul Roepman, Ian J. Majewski, Gabriel Capellá, Teresa Macarulla, Lodewyk F. A. Wessels, Ramon Salazar, Mireille Snel, Iris Simon, Andreas Schlicker, Josep Tabernero, René Bernards, Victor Moreno, Ulrich Nitsche, George Orphanides, Christine M. Chresta, Sun Tian, Robert D. Rosenberg
Publikováno v:
International Journal of Cancer. Journal International du Cancer
International Journal of Cancer; Vol 134
International Journal of Cancer, 134 (3), 2013
International Journal of Cancer; Vol 134
International Journal of Cancer, 134 (3), 2013
In most colorectal cancer (CRC) patients, outcome cannot be predicted because tumors with similar clinicopathological features can have differences in disease progression and treatment response. Therefore, a better understanding of the CRC biology is
Autor:
John Ashby, Helen Tinwell, Nicola Doherty, George Orphanides, Fei Ling Lim, Ian Kimber, Reginald Davies, Andrew G. Smith, Ruth Stuckey, David J. Moore, Jonathan G. Moggs, Tom Aldridge
Publikováno v:
Molecular and Cellular Endocrinology. 253:22-29
We have previously used genome-wide transcript profiling to investigate the relationships between changes in gene expression and physiological alterations during the response of the immature mouse uterus to estrogens. Here we describe the identificat
Autor:
Diana Rembges, David H. Blakey, Daniela Maurici, Susanna-Assunta Sansone, Hans Jürgen Ahr, Leonard M. Schechtman, Ian Indans, George Orphanides, Tohru Inoue, John P. Groten, Raffaella Corvi, Joost H.M. van Delft, Bernd Haase, Sylvio Albertini, Eisaku Toda, Karen Hamernik, Weida Tong, Libero Clerici, Brenda K. Weis, Thomas Hartung, George R. Douglas, Sandra Coecke, Laura Gribaldo, Jason Snape
Publikováno v:
Environmental Health Perspectives
Environmental Health Perspectives, 114(3), 420-429. U.S. Department of Health and Human Services; National Institute of Environmental Health Sciences
Environmental Health Perspectives, 114(3), 420-429. U.S. Department of Health and Human Services; National Institute of Environmental Health Sciences
This is the report of the first workshop "Validation of Toxicogenomics-Based Test Systems" held 11-12 December 2003 in Ispra, Italy. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and organized jointl
Autor:
George Orphanides, Anhco Nguyen, Julie P.I. Welburn, Martin E.M. Noble, Michael B. Yaffe, Jonathan G. Moggs, David Clynes, John W. Edmunds, Louis C. Mahadevan, Neil Macdonald, Jane A. Endicott, Stuart Thomson, Alison L. Clayton
Publikováno v:
Molecular Cell. 20(2):199-211
Phosphorylation of histone H3 is implicated in transcriptional activation and chromosome condensation, but its immediate molecular function has remained obscure. By affinity chromatography of nuclear extracts against modified H3 tail peptides, we ide
Publikováno v:
Handbook of Toxicogenomics: Strategies and Applications
Autor:
John Ashby, Hur Song Chang, Fei Ling Lim, Helen Tinwell, Ruth Stuckey, George Orphanides, Ian Kimber, Tracey Spurway, Tong Zhu, Anthony R. Soames, David J. Moore, Jonathan G. Moggs, Ian Pate, Richard A. Currie
Publikováno v:
Environmental Health Perspectives
A major challenge in the emerging field of toxicogenomics is to define the relationships between chemically induced changes in gene expression and alterations in conventional toxicologic parameters such as clinical chemistry and histopathology. We ha
Autor:
Fei Ling Lim, Ian Kimber, David J. Moore, Jonathan G. Moggs, George Orphanides, Helen Tinwell, John Ashby
Publikováno v:
Scopus-Elsevier
Environmental Health Perspectives
Environmental Health Perspectives
We used gene expression profiling to investigate whether the molecular effects induced by estrogens of different provenance are intrinsically similar. In this article we show that the physiologic estrogen 17-beta-estradiol, the phytoestrogen genistei
Publikováno v:
Toxicology Letters. 149:51-58
It is becoming increasingly apparent that toxicant-induced changes in epigenetic status, particularly DNA methylation patterns, may play a role in some mechanisms of toxicity. Here, we discuss briefly the evidence that alterations in DNA methylation
Autor:
George Orphanides, Jonathan G. Moggs
Publikováno v:
Toxicological Sciences. 80:218-224
Eukaryotic cells store their genetic information in the form of a highly organized nucleoprotein complex termed chromatin. The high degree of compaction of DNA within chromatin places severe constraints on proteins that require access to the DNA temp