Zobrazeno 1 - 10
of 37
pro vyhledávání: '"George O. Lovrecz"'
Autor:
Hans J Netter, Timothy E. Adams, Renae Walsh, Morten Thaysen-Andersen, Sayantani Chatterjee, Stephen Locarnini, George O. Lovrecz, Carina Joe, Peter M. Smooker
Publikováno v:
Vaccine. 38:3892-3901
Virus-like particles (VLP) represent biological platforms for the development of novel products such as vaccines and delivery platforms for foreign antigenic sequences. VLPs composed of the small surface antigen (HBsAgS) derived from the hepatitis B
Autor:
Thomas Nebl, Joel P. Mackay, Jason Low, William J. McKinstry, Jan Shaw, Bin Ren, George O. Lovrecz, Lenka Bittova, Lindsay G. Sparrow, Ronald J. Hill, Marek Jindra, Louis Lu, Tram Phan
Publikováno v:
The Journal of Biological Chemistry
Juvenile hormone (JH) plays vital roles in insect reproduction, development, and in many aspects of physiology. JH primarily acts at the gene-regulatory level through interaction with an intracellular receptor (JHR), a ligand-activated complex of tra
Autor:
Michael N.T. Souter, Wael Awad, Shihan Li, Troi J. Pediongco, Bronwyn S. Meehan, Lucy J. Meehan, Zehua Tian, Zhe Zhao, Huimeng Wang, Adam Nelson, Jérôme Le Nours, Yogesh Khandokar, T. Praveena, Jacinta Wubben, Jie Lin, Lucy C. Sullivan, George O. Lovrecz, Jeffrey Y.W. Mak, Ligong Liu, Lyudmila Kostenko, Katherine Kedzierska, Alexandra J. Corbett, David P. Fairlie, Andrew G. Brooks, Nicholas A. Gherardin, Adam P. Uldrich, Zhenjun Chen, Jamie Rossjohn, Dale I. Godfrey, James McCluskey, Daniel G. Pellicci, Sidonia B.G. Eckle
Publikováno v:
The Journal of experimental medicine. 219(9)
Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I)–related protein 1 (MR1). Most MAIT cells in human peripheral blood
Autor:
S Pillai, Bei Dong, George O. Lovrecz, Joanne M. Caine, Surinder P. Singh, James Robertson Petrie, Judith A. Scoble, Susan MacIntosh, Michelle L. Colgrave, Xue-Rong Zhou, Keren Byrne, Lukasz Kowalczyk
Publikováno v:
Food and Chemical Toxicology. 130:89-98
The measurement of protein digestibility is one of the key steps in determining the safety of a genetically modified crop that has been traditionally accomplished using antibodies. Membrane proteins are often extremely difficult to express with repli
Autor:
Liriye Kurtovic, Carina Joe, Renae Walsh, Hans J Netter, Natalie J Kingston, Stephen Locarnini, George O. Lovrecz, James G. Beeson
Publikováno v:
Vaccine. 37:1674-1684
The repetitive structure of compact virus-like particles (VLPs) provides high density displays of antigenic sequences, which trigger key parts of the immune system. The hepatitis B virus (HBV) and human papilloma virus (HPV) vaccines exploit the asse
Publikováno v:
The FASEB Journal. 33:5058-5066
Systemic endothelial dysfunction is a key characteristic of preeclampsia (PE), which is a serious disorder of human pregnancy. We have previously reported that high-temperature requirement factor (Htr)A4 is a placenta-specific protease that is secret
Autor:
Alexandra J. Corbett, Sidonia B G Eckle, George O. Lovrecz, David P. Fairlie, Louis Lu, Alison L. Every, Troi J. Pediongco, Huimeng Wang, Criselle D'Souza, Lyudmila Kostenko, Ligong Liu, Jeffrey Y. W. Mak, Zhenjun Chen, Andrew Stent, Hanwei Cao, Robyn Esterbauer, Richard A. Strugnell, James McCluskey, Jean-Pierre Y. Scheerlinck, Jamie Rossjohn, Bronwyn S. Meehan
Publikováno v:
The Journal of Immunology. 200:1901-1916
Mucosal-associated invariant T (MAIT) cells produce inflammatory cytokines and cytotoxic granzymes in response to by-products of microbial riboflavin synthesis. Although MAIT cells are protective against some pathogens, we reasoned that they might co
Autor:
Adam Hagg, Hongwei Qian, Emily K. Kelly, George O. Lovrecz, Justin L. Chen, Kelly L. Walton, Paul Gregorevic, Quinn Arnold, Mylinh La, Timothy D. Colgan, Louis Lu, Craig A. Harrison
Publikováno v:
Endocrinology. 160(10)
In cancer, elevated activin levels promote cachectic wasting of muscle, irrespective of tumor progression. In excess, activins A and B use the myostatin signaling pathway in muscle, triggering a decrease in protein synthesis and an increase in protei
Autor:
Jeffrey Y. W. Mak, Criselle D'Souza, David P. Fairlie, Troi J. Pediongco, Mai Shi, Sidonia B G Eckle, Alexandra J. Corbett, Barbara Fazekas de St Groth, Bronwyn S. Meehan, Bingjie Wang, Lars Kjer-Nielsen, Xin Yi Lim, Tianyuan Zhu, George O. Lovrecz, Michele W.L. Teng, Di Yu, Huimeng Wang, James McCluskey, Jamie Rossjohn, Zhenjun Chen, Hanwei Cao, Louis Lu, Richard A. Strugnell, Lyudmila Kostenko, Zhe Zhao
Publikováno v:
Science immunology. 4(41)
Mucosal-associated invariant T (MAIT) cells are activated in a TCR-dependent manner by antigens derived from the riboflavin synthesis pathway, including 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU), bound to MHC-related protein-1 (MR1).
Autor:
Renae Walsh, Hans J Netter, Morten Thaysen-Andersen, Louis Lu, George O. Lovrecz, Stephen Locarnini, Mylinh La, Natalie J Kingston, Nicolle H. Packer, Michiko Hyakumura
Publikováno v:
Journal of Virology. 89:11312-11322
The small envelope proteins (HBsAgS) derived from hepatitis B virus (HBV) represent the antigenic components of the HBV vaccine and are platforms for the delivery of foreign antigenic sequences. To investigate structure-immunogenicity relationships f