Zobrazeno 1 - 9
of 9
pro vyhledávání: '"George Nicolae Daniel Ion"'
Publikováno v:
Life, Vol 13, Iss 8, p 1635 (2023)
PIM-1 kinase is a serine-threonine phosphorylating enzyme with implications in multiple types of malignancies, including prostate, breast, and blood cancers. Developing better search methodologies for PIM-1 kinase inhibitors may be a good strategy to
Externí odkaz:
https://doaj.org/article/5cbf5bc0d7a5432886adf81002fb5963
Publikováno v:
Molecules, Vol 25, Iss 8, p 1766 (2020)
Protein kinases play a pivotal role in signal transduction, protein synthesis, cell growth and proliferation. Their deregulation represents the basis of pathogenesis for numerous diseases such as cancer and pathologies with cardiovascular, nervous an
Externí odkaz:
https://doaj.org/article/b40608e215ca47ff99a372690a907882
Autor:
Dragos Paul Mihai, George Mihai Nitulescu, George Nicolae Daniel Ion, Cosmin Ionut Ciotu, Cornel Chirita, Simona Negres
Publikováno v:
Pharmaceutics, Vol 11, Iss 9, p 446 (2019)
Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS) through neurodegeneration and demyelination, leading to physical/cognitive disability and neurological defects. A viable target for treating MS appears
Externí odkaz:
https://doaj.org/article/1e5e7f8d107748a8a162186bc93b25b8
Autor:
Octavian Tudorel Olaru, Tatiana I. Burykina, Georgiana Nitulescu, Demetrios A. Spandidos, George Mihai Nitulescu, Iulia Olaru, George Nicolae Daniel Ion, Aristidis Tsatsakis
Publikováno v:
Oncology Reports
One of the most commonly discussed topics in the field of drug discovery is the continuous search for anticancer therapies, in which small‑molecule development plays an important role. Although a number of techniques have been established over the
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:2527-2534
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), also known as Apo2L, has been investigated in the past decade for its promising anticancer activity due to its ability to selectively induce apoptosis in tumoral cells by binding to TRA
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 37:3674-3685
Targeting beta-secretase 1, also known as beta-amyloid precursor protein-cleaving enzyme (BACE-1) for the inhibition of amyloid production, has been intensely studied in the last decades in the search for stopping Alzheimer's disease (AD) progression
Autor:
Georgiana Nitulescu, Sterghios Moschos, Aristidis Tsatsakis, Demetrios A. Spandidos, George Nicolae Daniel Ion, Dimitrios Petrakis, Nikolaos Drakoulis, Taxiarchis Konstantinos Nikolouzakis, Horia Paunescu, George Mihai Nitulescu
Publikováno v:
International Journal of Molecular Medicine
The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) focused many researchers attention to find treatments that can suppress transmission or ameliorate the disease. Despite the very fast and large flow of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b00211255bbbafe523b9175c334c9c3
https://nrl.northumbria.ac.uk/id/eprint/43822/1/ijmm_46_2_467_PDF.pdf
https://nrl.northumbria.ac.uk/id/eprint/43822/1/ijmm_46_2_467_PDF.pdf
Publikováno v:
Proceedings of 5th International Electronic Conference on Medicinal Chemistry.
Background: Many successful drugs have been developed in the pharmaceutical industry starting from hits discovered by High-throughput Screening (HTS) methods, through various types of assays testing thousands of compounds against targets of interest
Autor:
Cornel Chirita, Dragos Paul Mihai, George Nicolae Daniel Ion, Simona Negres, Cosmin I Ciotu, George Mihai Nitulescu
Publikováno v:
Pharmaceutics
Volume 11
Issue 9
Pharmaceutics, Vol 11, Iss 9, p 446 (2019)
Volume 11
Issue 9
Pharmaceutics, Vol 11, Iss 9, p 446 (2019)
Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS) through neurodegeneration and demyelination, leading to physical/cognitive disability and neurological defects. A viable target for treating MS appears