Zobrazeno 1 - 10
of 21
pro vyhledávání: '"George N. Welch"'
Autor:
Joseph Loscalzo, George N. Welch
Publikováno v:
New England Journal of Medicine. 338:1042-1050
In 1969, McCully made the clinical observation linking elevated plasma homocyst(e)ine concentrations with vascular disease.1 He reported autopsy evidence of extensive arterial thrombosis and atherosclerosis in two children with elevated plasma homocy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1359:143-152
The control of medial and neointimal growth, in which vascular smooth muscle (VSM) plays a central role, is most important to the development of hypertension and atherosclerosis, respectively. Growth of vascular smooth muscle cells is regulated by a
Autor:
Attila J. Fabian, George N. Welch, Gilbert R. Upchurch, John F. Keaney, Alessio Pigazzi, Joseph Loscalzo
Publikováno v:
Atherosclerosis. 132:177-185
Hyperhomocyst(e)inemia, characterized by accelerated atherosclerosis, is believed to induce endothelial cell injury and promote atherothrombosis by supporting the generation of hydrogen peroxide. Earlier observations in our laboratory demonstrated th
Autor:
Gilbert R. Upchurch, John F. Keaney, George N. Welch, Joseph L. Johnson, Attila J. Fabian, Joseph Loscalzo, Jane E. Freedman
Publikováno v:
Journal of Biological Chemistry. 272:17012-17017
Hyperhomocyst(e)inemia is believed to injure endothelial cells in vivo through a number of mechanisms, including the generation of hydrogen peroxide (H2O2). Earlier in vitro studies demonstrated that homocyst(e)ine (Hcy) decreases the biological acti
Autor:
S. Francis, Gina Ragno, Gilbert R. Upchurch, M. J. Rohrer, C. R. Valeri, H. MacGregor, George N. Welch, Shukri F. Khuri, Alan D. Michelson, L. J. Rodino, Joseph Loscalzo
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 271:H528-H534
Heparin, a polyanionic glycosaminoglycan, is used routinely before the induction of cardiopulmonary bypass. Earlier observations in our laboratory suggested that the postoperative bleeding that occurs, despite neutralization of heparin with protamine
Publikováno v:
Vascular Medicine. 1:25-33
Nitric oxide (NO) is a simple heterodiatomic molecule with a broad range of biologic actions. In the cardiovascular system NO serves as an endothelium-dependent vasodilator, an antithrombotic agent, an antiproliferative molecule, and a regulator of c
Publikováno v:
Blood Reviews. 9:262-269
Nitric oxide is a simple diatomic molecule that is involved in a wide variety of physiologic processes in the vasculature. Nitric oxide is an important determinant of vascular tone, regulates endothelial integrity, and modulates platelet-vessel wall
Autor:
George N. Welch, Joseph Loscalzo
Publikováno v:
Progress in Cardiovascular Diseases. 38:87-104
Nitric oxide (NO) is a ubiquitous, naturally occurring molecule found in a variety of cell types and organ systems. In the cardiovascular system, NO is an important determinant of basal vascular tone, prevents platelet activation, limits leukocyte ad
Publikováno v:
Journal of cardiovascular pharmacology and therapeutics. 3(2)
Background: Nitric oxide (NO), a potent vasodilator and inhibitor of platelet function, is elaborated constitutively by endothelial cells through the oxidation of L-arginine by endo thelial NO synthase. Although several biochemical agonists, such as
Publikováno v:
Hospital practice (1995). 32(6)
First recognized in patients with rare inborn errors of metabolism, the association of elevated plasma homocysteine concentrations with atherosclerosis and thrombosis now seems relevant to the general population as well. The mechanism of injury appea