Zobrazeno 1 - 10
of 32
pro vyhledávání: '"George N. Naumov"'
Autor:
George N. Naumov, Judah Folkman, Randolph S. Watnick, Lars A. Akslen, Oddbjorn Straume, Karl-Henning Kalland, Kamila Naxerova, Soo-Young Kang, Michael Lampa, Elise R. Bender, Anne M. Oyan, Trond H. Bø, Eugene Lifshits, Anna Blois, Lorna M. Cryan, David Zurakowski, Katherine Novak, Michael S. Rogers
PDF - 120K, Supplementary Methods and legends for Supplementary Figures 1 through 3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d39b13f33c4d104b3ddc250bb8dbe25
https://doi.org/10.1158/1541-7786.22511149
https://doi.org/10.1158/1541-7786.22511149
Autor:
George N. Naumov, Judah Folkman, Randolph S. Watnick, Lars A. Akslen, Oddbjorn Straume, Karl-Henning Kalland, Kamila Naxerova, Soo-Young Kang, Michael Lampa, Elise R. Bender, Anne M. Oyan, Trond H. Bø, Eugene Lifshits, Anna Blois, Lorna M. Cryan, David Zurakowski, Katherine Novak, Michael S. Rogers
PDF - 254K, Supplemental Figure 1: In vivo proliferation of angiogenic and non-angiogenic cell clones. Supplemental Figure 2: Chromosomal locations of genes with relative overexpression in either angiogenic or revertant clones. Supplemental Figure 3:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2840e66b0b57dfe1809c6a721fb80d
https://doi.org/10.1158/1541-7786.22511152
https://doi.org/10.1158/1541-7786.22511152
Autor:
Pasi A. Jänne, Kwok-Kin Wong, Matthew Meyerson, John V. Heymach, James M. Nelson, Geoffrey I. Shapiro, Leena Gandhi, Irene W. Althaus, James E. Bradner, George N. Naumov, Patrick W. Vincent, Feng Zhao, Takeshi Shimamura, Andrea J. Gonzales, Eugene Lifshits, Christopher-Michael Gale, Kreshnik Zejnullahu, Jeffrey A. Engelman
Supplementary Table 1 from PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with EGFR and ERBB2 Mutations that Are Resistant to Gefitinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c0ed7094f35e06853396808bc4bc65
https://doi.org/10.1158/0008-5472.22370564.v1
https://doi.org/10.1158/0008-5472.22370564.v1
Autor:
Pasi A. Jänne, Kwok-Kin Wong, Matthew Meyerson, John V. Heymach, James M. Nelson, Geoffrey I. Shapiro, Leena Gandhi, Irene W. Althaus, James E. Bradner, George N. Naumov, Patrick W. Vincent, Feng Zhao, Takeshi Shimamura, Andrea J. Gonzales, Eugene Lifshits, Christopher-Michael Gale, Kreshnik Zejnullahu, Jeffrey A. Engelman
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors gefitinib and erlotinib are effective treatments for a subset of non–small cell lung cancers. In particular, cancers with specific EGFR-activating mutations seem to be the most sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c24e94b1432d71a7047c9e0610b8a6
https://doi.org/10.1158/0008-5472.c.6496436
https://doi.org/10.1158/0008-5472.c.6496436
Autor:
Michael Lampa, Randolph S. Watnick, Oddbjørn Straume, Trond Hellem Bø, Katherine Novak, Michael S. Rogers, Lars A. Akslen, George N. Naumov, Lorna M. Cryan, Eugene Lifshits, Elise Bender, Kamila Naxerova, Judah Folkman, Anna Blois, Karl-Henning Kalland, Soo-Young Kang, Anne Margrete Øyan, David Zurakowski
Publikováno v:
Molecular Cancer Research. 12:754-764
The angiogenic switch, a rate-limiting step in tumor progression, has already occurred by the time most human tumors are detectable. However, despite significant study of the mechanisms controlling this switch, the kinetics and reversibility of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39d0a4136d4e8a2c65effd76a587da0d
https://doi.org/10.1158/1541-7786.mcr-13-0532-t
https://doi.org/10.1158/1541-7786.mcr-13-0532-t
Autor:
John V. Heymach, Eugene Lifshits, George N. Naumov, Tina Cascone, Daniel G. Tenen, Bruce E. Johnson, Lars A. Akslen, Jeffrey A. Engelman, Monique B. Nilsson, Hua Kang Wu, Oddbjørn Straume, Pasi A. Jänne, Beow Y. Yeap, Balazs Halmos, Xi M. Tang, Alexandra Briggs, Judah Folkman, Lauren Averett Byers, Li Xu, Susumu Kobayashi
Publikováno v:
Clinical Cancer Research. 15:3484-3494
Purpose: The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) gefitinib and erlotinib benefit some non–small cell lung cancer (NSCLC) patients, but most do not respond (primary resistance) and those who initially respond eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a2ea89b5df0539a0e523946c8d144b
https://doi.org/10.1158/1078-0432.ccr-08-2904
https://doi.org/10.1158/1078-0432.ccr-08-2904
Autor:
Joseph E. Italiano, Judah Folkman, Tai-Tung Yip, Abdo Abou-Slaybi, Nandita Bhattacharya, Nava Almog, George N. Naumov, Elise Bender, Jon E. Peterson, Vladimir N. Podust, Giannoula Klement, David Cervi
Publikováno v:
Blood. 111:1201-1207
Early tumor detection and intervention are important determinants of survival in patients with cancer. We have recently reported that the “platelet angiogenesis proteome” may be used to detect microscopic tumors in mice. We now present evidence t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ab202ef5f5155099b4fd298106a387
https://doi.org/10.1182/blood-2007-04-084798
https://doi.org/10.1182/blood-2007-04-084798
Autor:
Xihong Lin, Takeshi Shimamura, Diego H. Castrillon, Bruce E. Johnson, Danan Li, Matthew R. Ramsey, Lucian R. Chirieac, Jussi Koivunen, Geoffrey I. Shapiro, David J. Kwiatkowski, David C. Christiani, Lei Bao, Pasi A. Jänne, Kate McNamara, Piotr Kozlowski, Mei-Chih Liang, Janakiraman Krishnamurthy, Chad Torrice, Hongbin Ji, Matthew Meyerson, Cristina Contreras, D. Neil Hayes, Roderick T. Bronson, Neal I. Lindeman, George N. Naumov, Samanthi A. Perera, Cheng Fan, Nabeel Bardeesy, Robert F. Padera, Kwok-Kin Wong, Michael C. Wu, Dongpo Cai, Norman E. Sharpless, Liang Chen
Publikováno v:
Nature. 448:807-810
Germline mutation in serine/threonine kinase 11 (STK11, also called LKB1) results in Peutz-Jeghers syndrome, characterized by intestinal hamartomas and increased incidence of epithelial cancers. Although uncommon in most sporadic cancers, inactivatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02edde4254e120b127a992c97de43e6
https://doi.org/10.1038/nature06030
https://doi.org/10.1038/nature06030
Autor:
Lewis C. Cantley, George N. Naumov, John V. Heymach, Ana M. Borras, Bruce E. Johnson, Christopher Michael Gale, Toru Mukohara, Emily T Jarrell, Beow Y. Yeap, Pasi A. Jänne, Jeffrey A. Engelman, Jason Sun, Kreshnik Zejnullahu, Sean Tracy, Xiaojun Zhao, Eugene Lifshits
Publikováno v:
Journal of Clinical Investigation. 116:2695-2706
EGFR is frequently mutated and amplified in lung adenocarcinomas sensitive to EGFR inhibitors gefitinib and erlotinib. A secondary mutation, T790M, has been associated with acquired resistance but has not been shown to be sufficient to render EGFR mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4505db1746fa10a86c973b6ef42671d8
https://doi.org/10.1172/jci28656
https://doi.org/10.1172/jci28656
Autor:
Lars A. Akslen, Evelyn Flynn, George N. Naumov, David A. Sampson, Randolph S. Watnick, Oddbjørn Straume, Elise Bender, Judah Folkman, David Zurakowski, Soo-Young Kang, Nava Almog
Publikováno v:
JNCI: Journal of the National Cancer Institute. 98:316-325
Background: Microscopic human cancers can remain dormant for life . Tumor progression depends on sequential events, including a switch to the angiogenic phenotype, i.e., initial recruitment of new vessels . We previously demonstrated that human tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8489a9896adf3ab4c2f58ddaff7937d
https://doi.org/10.1093/jnci/djj068
https://doi.org/10.1093/jnci/djj068