Zobrazeno 1 - 10
of 63
pro vyhledávání: '"George N. Henderson"'
Autor:
S. Ananth Karumanchi, Kyung Mee Kim, Witcha Imaram, George N. Henderson, Richard J. Johnson, Christine Gersch, Alexander Angerhofer, Sergiu P. Palii
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 28:118-149
Hyperuricemia is associated with hypertension, metabolic syndrome, preeclampsia, cardio-vascular disease and renal disease, all conditions associated with oxidative stress. We hypothesized that uric acid, a known antioxidant, might become prooxidativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9f37ecf042a56fd6f436bc1218cf9d
https://doi.org/10.1080/15257770902736400
https://doi.org/10.1080/15257770902736400
Autor:
Richard J. Johnson, George N. Henderson, Loreto Gesualdo, Philip M. Scherer, Michael S. Gersch, Yuri Y. Sautin, Pietro Cirillo, Wei Mu, Kyung Mee Kim
Publikováno v:
Journal of the American Society of Nephrology. 20:545-553
Increased consumption of fructose may play an important role in the epidemic of metabolic syndrome and may presage the development of diabetes, cardiovascular disease, and chronic kidney disease. Once in the cell, fructose is phosphorylated by ketohe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5258a3e653296cebe094b3b6397c39a
https://doi.org/10.1681/asn.2008060576
https://doi.org/10.1681/asn.2008060576
Autor:
George N. Henderson, Alexander Angerhofer, Sergiu P. Palii, Christine Gersch, Richard J. Johnson, Kyung Mee Kim
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 27:967-978
The 1980 identification of nitric oxide (NO) as an endothelial cell-derived relaxing factor resulted in an unprecedented biomedical research of NO and established NO as one of the most important cardiovascular, nervous and immune system regulatory mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31fef6874dfd7672accb9cfd09d0afd
https://doi.org/10.1080/15257770802257952
https://doi.org/10.1080/15257770802257952
Autor:
Yuri Y. Sautin, Richard J. Johnson, George N. Henderson, Eric A. Gaucher, Alexander Angerhofer, Steven A. Benner
Publikováno v:
Medical Hypotheses. 71:22-31
Humans have relatively low plasma ascorbate levels and high serum uric acid levels compared to most mammals due to the presence of genetic mutations in l-gulonolactone oxidase and uricase, respectively. We review the major hypotheses for why these mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db9146e7db72b9da73c8f1c8451fb8e
https://doi.org/10.1016/j.mehy.2008.01.017
https://doi.org/10.1016/j.mehy.2008.01.017
Publikováno v:
Clinica Chimica Acta. 350:219-230
Several acquired and congenital human disorders perturb the concentrations of delta-aminolevulinate (delta-ALA), creatinine and tyrosine in biological fluids. There is currently no facile, sensitive and specific method to measure these analytes simul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fa6fce2abff8c891e4fea0cfae524c
https://doi.org/10.1016/j.cccn.2004.08.009
https://doi.org/10.1016/j.cccn.2004.08.009
Autor:
George N. Henderson, Peter W. Stacpoole, Wells W. Wu, Paul A. Chadik, Minghong Jia, Richard A. Yost
Publikováno v:
Analytical Chemistry. 75:4065-4080
Haloacetic acids (HAAs) are environmentally and medically important chemicals. No analytical method is currently available to analyze EPA-regulated HAAs in biological samples at environmentally relevant low concentrations. Clinical studies of this cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a19c9711f2edcc1e8c3f37ab1b0fe61
https://doi.org/10.1021/ac034036w
https://doi.org/10.1021/ac034036w
Autor:
George N. Henderson, Peter W. Stacpoole, Sanjeev Krishna, Tim Planche, Tsiri Agbenyega, Daniel Ansong, Nelamangala V. Nagaraja, Hartmut Derendorf, Alex Owusu-Ofori, Alan D. Hutson, George Bedu-Addo, Albert L. Shroads, Venkatesh Atul Bhattaram
Publikováno v:
The Journal of Clinical Pharmacology. 43:386-396
The authors conducted a randomized, double-blind, placebo-controlled trial of intravenous dichloroacetate (DCA) for the purpose of treating lactic acidosis in 124 West African children with severe Plasmodium falciparum malaria. Lactic acidosis indepe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ecea6b3643535d88f265dfa31af1e2
https://doi.org/10.1177/0091270003251392
https://doi.org/10.1177/0091270003251392
Autor:
George N. Henderson, Hartmut Derendorf, Tim Planche, Nelamangala V. Nagaraja, Alex Owusu-Ofori, Tsiri Agbenyega, George Bedo-Addo, Alan D. Hutson, Albert L. Shroads, Sanjeev Krishna, Peter W. Stacpoole, Daniel Ansong
Publikováno v:
Antimicrobial Agents and Chemotherapy. 45:1803-1809
We present the first population pharmacokinetic analysis of quinine in patients with Plasmodium falciparum malaria. Ghanaian children ( n = 120; aged 12 months to 10 years) with severe malaria received an intramuscular loading dose of quinine dihydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad2a54383cbd9b6f18ce292188c003b
https://doi.org/10.1128/aac.45.6.1803-1809.2001
https://doi.org/10.1128/aac.45.6.1803-1809.2001
Autor:
Stephen H. Curry, Elizabeth C. Wright, George N. Henderson, Hartmut Derendorf, Peter W. Stacpoole
Publikováno v:
The Journal of Clinical Pharmacology. 37:416-425
The pharmacokinetic properties of the lactate-lowering drug dichloroacetate were investigated in 111 adult patients with lactic acidosis who were randomized to receive dichloroacetate as part of a placebo-controlled clinical trial. The clinical sympt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c0341e23b34955f961750238f5fcff
https://doi.org/10.1002/j.1552-4604.1997.tb04319.x
https://doi.org/10.1002/j.1552-4604.1997.tb04319.x
Autor:
Barbara Zorovich, Stephen H. Curry, Stephen H. Schneider, Steven Jenkinson, Peter W. Stacpoole, George N. Henderson, John M. Lachin, Charles A. Duncan, Christopher L. Wolfe, Thomas G. Baumgartner, Elizabeth C. Wright, Eloise Harman, Warren R. Summer, John H. Siegel, Douglas A. Thompson, A. Lorenz, Robert M. Bersin, Scott E. Buchalter
Publikováno v:
The American Journal of Medicine. 97:47-54
study objective: To determine the pathogenesis and clinical course of lactic acidosis in adults receiving standard medical care. design: Placebo arm of a 5-year prospective, randomized, blinded study comparing placebo and dichloroacetate as specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::959e392e12547f882fa657b375050872
https://doi.org/10.1016/0002-9343(94)90047-7
https://doi.org/10.1016/0002-9343(94)90047-7