The genome of the gymnosperm Picea glauca encodes a single Nucleobase Cation Symporter 1 (PgNCS1) that displays a broad yet unique solute specificity profile

Autor: George Mourad, Candace R. Alexander, Kevin A. Hunt, Jessica R. Schein, Mahanish J. Thapa, Laura Mack, Neil P. Schultes

Publikováno v: Plant Cell, Tissue and Organ Culture (PCTOC). 146:237-247

The Picea glauca genome contains a locus that encodes for a nucleobase cation symporter 1 (PgNCS1). As a gymnosperm, P. glauca belongs to a key taxonomic position for an ongoing evolution-function analysis of viridiplantae nucleobase cation symporter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7fd27bbaca3a8d3aabbed7ba2dfcdb7
https://doi.org/10.1007/s11240-021-02063-w

Optimized low-dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment

Autor: Andrea Weiss, Connie R. Jimenez, Patrycja Nowak-Sliwinska, Pierre-Yves Dietrich, Alexander A. Henneman, Marloes Zoetemelk, Mylène Docquier, Youssef Daali, Thibaud Koessler, Magdalena Rausch, Céline Delucinge-Vivier, Thomas Alexander Mckee, Axel Andres, Christian Toso, Tatiana V. Petrova, Richard R. de Haas, Simone Ragusa, Sander R. Piersma, George Mourad Ramzy, Arjan W. Griffioen, Valentin Mieville, Laura Rubbia-Brandt, Judy R. van Beijnum

Publikováno v: Molecular Oncology
Molecular oncology, vol. 14, no. 11, pp. 2894-2919
Molecular Oncology (2020)
Zoetemelk, M, Ramzy, G M, Rausch, M, Koessler, T, van Beijnum, J R, Weiss, A, Mieville, V, Piersma, S R, de Haas, R R, Delucinge-Vivier, C L, Andres, A, Toso, C, Henneman, A A, Ragusa, S, Petrova, T V, Docquier, M, McKee, T A, Jimenez, C R, Daali, Y, Griffioen, A W, Rubbia-Brandt, L, Dietrich, P-Y & Nowak-Sliwinska, P 2020, ' Optimized low-dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment ', Molecular oncology, vol. 14, no. 11, pp. 2894-2919 . https://doi.org/10.1002/1878-0261.12797
Molecular oncology, 14(11), 2894-2919. Elsevier
Molecular Oncology, Vol 14, Iss 11, Pp 2894-2919 (2020)

Therapeutically guided multidrug optimization (TGMO) technology, composed of experimental testing and in silico modelling, allowed identification of synergistic and selective low‐dose optimized drug combinations (ODCs) active in multiple colorectal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697c0adf39c6243b6ff93e1d09b7bbfb
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85092087787&origin=inward

Functional characterization of the adenine transporter EaAdeP from the fire blight pathogen Erwinia amylovora and its effect on disease establishment in apples and pears

Autor: Neil P. Schultes, Regan B. Huntley, Candace R. Alexander, George Mourad

Publikováno v: FEMS microbiology letters. 367(20)

Erwinia amylovora is the causal agent of fire blight, an economically important disease of apples and pears. As part of the infection process, Er. amylovora propagates on different plant tissues each with distinct nutrient environments. Here, the bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520649332a45525cf771e90480821c2d
https://pubmed.ncbi.nlm.nih.gov/33152083

Functional characterization of the uracil transporter from honeybee pathogen Paenibacillus larvae

Autor: George Mourad, Amanda J. Stoffer-Bittner, Neil P. Schultes, Candace R. Alexander, Douglas W. Dingman

Publikováno v: Microbial Pathogenesis. 124:305-310

The genome of the Honeybee bacterial pathogen, Paenibacillus larvae, encodes for protein a with substantial amino acid sequence similarity to the canonical Escherichia coli uracil transporter UraA. P. larvae expresses the uracil permease (PlUP) locus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acdbe73e1fb79a6991e721856c5fc2a
https://doi.org/10.1016/j.micpath.2018.08.059

Identification of a Synergistic Multi-Drug Combination Active in Cancer Cells via the Prevention of Spindle Pole Clustering

Autor: Andrea Weiss, Katayoun Falamaki, Patrick Meraldi, Marijana Miljkovic-Licina, Marloes Zoetemelk, Bernard Wehrle-Haller, Daniela Harry, Magdalena Rausch, Patrycja Nowak-Sliwinska, George Mourad Ramzy, Morgan Le Roux-Bourdieu

Publikováno v: Cancers
Volume 11
Issue 10
Cancers, Vol. 11, No 10 (2019) P. 1612
Cancers, Vol 11, Iss 10, p 1612 (2019)

A major limitation of clinically used cancer drugs is the lack of specificity resulting in toxicity. To address this, we performed a phenotypically-driven screen to identify optimal multidrug combinations acting with high efficacy and selectivity in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666893051a25ac9692020e9eba9195a2