Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model

Autor: Imke Rudnik-Jansen, Karin Schrijver, Nina Woike, Anna Tellegen, Sabine Versteeg, Pieter Emans, George Mihov, Jens Thies, Niels Eijkelkamp, Marianna Tryfonidou, Laura Creemers

Publikováno v: Drug Delivery, Vol 26, Iss 1, Pp 226-236 (2019)

Inflammation of the synovium and joint capsule is a main driver of pain in an osteoarthritic (OA) joint. Triamcinolone acetonide (TAA) is a classical corticosteroid that reduces synovitis and alleviates pain, albeit transiently. Biomaterial-based loc

Externí odkaz: https://doaj.org/article/9e7b74ab86124f0b86ca8010f97063b2

Intra-Articular Slow-Release Triamcinolone Acetonide from Polyesteramide Microspheres as a Treatment for Osteoarthritis

Autor: Anna Tellegen, Martijn Beukers, Imke Rudnik-Jansen, Nicolien van Klaveren, Kan Loi How, Nina Woike, George Mihov, Jens Thies, Erik Teske, Laura Creemers, Marianna Tryfonidou, Björn Meij

Publikováno v: Pharmaceutics, Vol 13, Iss 3, p 372 (2021)

Osteoarthritis (OA) is a common cause of pain and disability. Local corticosteroid injections are effective in treating OA pain and inflammation but are short-acting. Prolonged intra-articular (IA) corticosteroid exposure may even lead to cartilage d

Externí odkaz: https://doaj.org/article/1b2b880f9c2f42448c239744b8b00e1a

Biocompatibility of Poly(ester amide) (PEA) Microfibrils in Ocular Tissues

Autor: Martina Kropp, Katharina-Marie Morawa, George Mihov, Anna Katharina Salz, Nina Harmening, Astrid Franken, Anja Kemp, Aylvin A. Dias, Jens Thies, Sandra Johnen, Gabriele Thumann

Publikováno v: Polymers, Vol 6, Iss 1, Pp 243-260 (2014)

Drug delivery systems (DDS) are able to deliver, over long periods of time, therapeutic concentrations of drugs requiring frequent administration. Two classes of DDS are available, biodegradable and non-biodegradable. The larger non-biodegradable imp

Externí odkaz: https://doaj.org/article/2a5cf4420c1e42a9ab798150c6ee8a74

Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration

Autor: Detlef Schumann, George Mihov, Maarten van Dijk, Clemens Bos, Guy C. M. Grinwis, Laura B. Creemers, Marianna A. Tryfonidou, Nicole Willems, Wouter J.A. Dhert, Björn P. Meij, Gustav J. Strijkers

Publikováno v: Journal of Biomedical Materials Research. Part B, Applied Biomaterials., 105(4), 707. John Wiley and Sons Inc.
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Journal of biomedical materials research. Part B, Applied biomaterials, 105(4), 707-714. John Wiley and Sons Inc.

Repair of degenerated intervertebral discs (IVD) might be established via intradiscal delivery of biologic therapies. Polyester amide polymers (PEA) were evaluated for in vitro cytotoxicity and in vivo biocompatibility, and thereafter intradiscal app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06b6402896ef32bcac2d06bae7faa1c
https://doi.org/10.1002/jbm.b.33579

Drugs and Polymers for Delivery Systems in OA Joints: Clinical Needs and Opportunities

Autor: Pieter J. Emans, Maarten P. F. Janssen, Jens Christoph Thies, Tim J. M. Welting, George Mihov

Publikováno v: Polymers, Vol 6, Iss 3, Pp 799-819 (2014)
Polymers, 6(3), 799-819. Multidisciplinary Digital Publishing Institute (MDPI)

Osteoarthritis (OA) is a big burden of disease worldwide and one of the most common causes of disability in the adult population. Currently applied therapies consist of physical therapy, oral medication, intra-articular injections, and surgical inter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcc3aacb5d2911425f2bc7507703eb4
http://www.mdpi.com/2073-4360/6/3/799