Zobrazeno 1 - 10
of 11
pro vyhledávání: '"George Miesegaes"'
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 68:83-89
At the 2009 meeting in Indianapolis, gaps and areas for improvement for individual unit operations were identified during an interactive closing session with the participants. A set of action items to address these gaps was drafted, and they were lis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b10c67047a3303dc973f154df158bd7
https://doi.org/10.5731/pdajpst.2014.00968
https://doi.org/10.5731/pdajpst.2014.00968
Autor:
Min Zhang, Melody Trexler-Schmidt, Kurt Brorson, Daniel Coleman, Philip Lester, Bin Yang, Michael Lee, Lenore A. Norling, George Miesegaes, Qi Chen
Publikováno v:
Biotechnology and Bioengineering
Protein A chromatography is widely used as a capture step in monoclonal antibody (mAb) purification processes. Antibodies and Fc fusion proteins can be efficiently purified from the majority of other complex components in harvested cell culture fluid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061f97024bb7a93dd17b84a4010bff7f
https://doi.org/10.1002/bit.24999
https://doi.org/10.1002/bit.24999
Autor:
Dayue Chen, Kurt Brorson, Rakhi B. Shah, Erik K. Read, Daniel Strauss, Adith Venkiteshwaran, Scott Lute, A Kreuzman, George Miesegaes, Parviz Ayazi Shamlou
Publikováno v:
Biotechnology and Bioengineering. 109:2048-2058
Traditionally, post-production culture harvest capture of therapeutic monoclonal antibodies (mAbs) is performed using Protein A chromatography. We investigated the efficiency and robustness of cation exchange chromatography (CEX) in an effort to eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3b84a5f99618d8d7be0ada3ad19671
https://doi.org/10.1002/bit.24480
https://doi.org/10.1002/bit.24480
Autor:
George Miesegaes
Publikováno v:
PDA journal of pharmaceutical science and technology. 68(1)
At the previous viral clearance symposium, insights into the general mechanism of viral clearance by cation exchange chromatography (CEX) were shared by Amgen and Novartis ([1][1]). Amgen presented data from multiple monoclonal antibody (mAb) product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c04d2099a3744226241ea62aad7f254
https://pubmed.ncbi.nlm.nih.gov/24504234
https://pubmed.ncbi.nlm.nih.gov/24504234
Publikováno v:
Biotechnology progress. 30(1)
Anion exchange (AEX) is a common downstream purification operation for biotechnology products manufactured in cell culture such as therapeutic monoclonal antibodies (mAbs) and Fc-fusion proteins. We present a head-to-head comparison of the viral clea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f11ce4234faacce763b971cac403e64
https://pubmed.ncbi.nlm.nih.gov/24167103
https://pubmed.ncbi.nlm.nih.gov/24167103
Autor:
Simran Kaushal, Kurt Brorson, Dayue Chen, Jessica Dement-Brown, George Miesegaes, Daniel Strauss, Scott Lute
Publikováno v:
PDA journal of pharmaceutical science and technology. 66(5)
Demonstration of effective and consistent viral clearance by small scale models of downstream processing, typically cited as logarithmic reduction value (LRV), is an important safety requirement for biotech products. LRVs have anecdotally been report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9105e2239936bce5f55b8e1a5af7b9fc
https://pubmed.ncbi.nlm.nih.gov/23035026
https://pubmed.ncbi.nlm.nih.gov/23035026
Publikováno v:
Encyclopedia of Industrial Biotechnology
Ensuring the absence of detectable viruses in biopharmaceutical products is imperative from both a regulatory and patient safety standpoint. Biopharmaceutical viral safety is the result of multiple orthogonal barriers operating in concert; incorporat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b132ff8d4c2b0bf744b7ee9172a1ed65
https://doi.org/10.1002/9780470054581.eib319
https://doi.org/10.1002/9780470054581.eib319
Publikováno v:
Biotechnology and Bioengineering.
Demonstration of viral clearance is a critical step in assuring the safety of biotechnology products. We generated a viral clearance database that contains product information, unit operation process parameters, and viral clearance data from monoclon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b766385088c33b9ea5561430282c87
https://doi.org/10.1002/bit.22662
https://doi.org/10.1002/bit.22662
Autor:
Tracey J. Shors, George Miesegaes
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 99(21)
Exposure to an acute stressful event can enhance learning in male rats, whereas exposure to the same event dramatically impairs performance in females. Here we tested whether the presence of sex hormones during early development organizes these oppos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b742bb47810a2082c334c7dcb4add33
https://pubmed.ncbi.nlm.nih.gov/12359876
https://pubmed.ncbi.nlm.nih.gov/12359876
Autor:
Tracy Rydel, Anna V. Beylin, Tracey J. Shors, George Miesegaes, Mingrui Zhao, Elizabeth Gould
Publikováno v:
Nature. 410(6826)
The vertebrate brain continues to produce new neurons throughout life. In the rat hippocampus, several thousand are produced each day, many of which die within weeks. Associative learning can enhance their survival; however, until now it was unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e51a48c207e00b2282fa2b2ee57d4e
https://pubmed.ncbi.nlm.nih.gov/11268187
https://pubmed.ncbi.nlm.nih.gov/11268187