Zobrazeno 1 - 10
of 11
pro vyhledávání: '"George Maxwell Otto"'
Publikováno v:
The Journal of Cell Biology
Autophagy
Autophagy
Otto et al. show that the cortical ER undergoes programmed collapse from the plasma membrane during meiosis. Collapse separates the ER into distinct populations and determines which regions are eligible for inheritance by gametes and which are degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b954fbbc3d2cfdf081af78d2f1bc49b9
http://europepmc.org/articles/PMC8562846
http://europepmc.org/articles/PMC8562846
Autor:
George Maxwell Otto, Gloria Ann Brar
Publikováno v:
Autophagy. 18:1732-1733
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68e2ab0c9d47cdd4a1f9449d197b52bc
https://doi.org/10.1080/15548627.2022.2040315
https://doi.org/10.1080/15548627.2022.2040315
Autor:
Michelle M. Frees, George Maxwell Otto, Sandra Wagner, David J. Odde, David A. Largaespada, Paramita Das, Pauline J. Beckmann, Rory L. Williams, Barbara R. Tschida, Robert B. Jenkins, Alex T. Larsson, Stephen C Schmechel, Quincy Rosemarie, Jon D. Larson, Charles G. Eberhart, Fausto J. Rodriguez, Eric P. Rahrmann, Xiaochong Wu, Jason Ostergaard, Jun Wang, Addison M. Demer, Michael D. Taylor, Daniel Picard, Adrian M. Dubuc, Ryan D Krebs, Catherine Lee, Annie Huang, Aaron L. Sarver, Robert J. Wechsler-Reya, Branden S. Moriarity, Anthony E. Rizzardi, Amy M. Molan, Ghaidan Shamsan
Publikováno v:
Cancer Research. 79:905-917
Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using Sleeping Beauty (SB) transposon mutagenesis, we identified novel genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40f8f826ae2377aa0bdaea941a7d85f
https://doi.org/10.1158/0008-5472.can-18-1261
https://doi.org/10.1158/0008-5472.can-18-1261
Autor:
Susan K. Rathe, Michael A. Linden, Timothy K. Starr, Laura B. Ramsey, David A. Largaespada, Natalie K. Wolf, Lynn M. Heltemes-Harris, Rebecca S. LaRue, Branden S. Moriarity, George Maxwell Otto, Michael A. Farrar, Eric P. Rahrmann, Jingmin Shu
Publikováno v:
Molecular Cancer Research. 17:567-582
Follicular lymphoma and diffuse large B-cell lymphoma (DLBCL) are the most common non-Hodgkin lymphomas distinguishable by unique mutations, chromosomal rearrangements, and gene expression patterns. Here, it is demonstrated that early B-cell progenit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef456372c9d1c8f1dd95959e24bfc06c
https://doi.org/10.1158/1541-7786.mcr-18-0582
https://doi.org/10.1158/1541-7786.mcr-18-0582
Programmed ER fragmentation drives selective ER inheritance and degradation in budding yeast meiosis
The endoplasmic reticulum (ER) is a membrane-bound organelle with diverse, essential functions that rely on the maintenance of membrane shape and distribution within cells. ER structure and function are remodeled in response to changes in cellular de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d2f8871bd063743ee53a00a1dff0b51
https://doi.org/10.1101/2021.02.12.430990
https://doi.org/10.1101/2021.02.12.430990
Autor:
Gloria A. Brar, George Maxwell Otto
Publikováno v:
Current Genetics
Current genetics, vol 64, iss 6
Current genetics, vol 64, iss 6
The development of techniques for measuring gene expression globally has greatly expanded our understanding of gene regulatory mechanisms in depth and scale. We can now quantify every intermediate and transition in the canonical pathway of gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e4eecafe065e1a32274c346dd26f1e
https://pubmed.ncbi.nlm.nih.gov/29675618
https://pubmed.ncbi.nlm.nih.gov/29675618
Autor:
Gloria A. Brar, Abdurrahman Keskin, Marko Jovanovic, George Maxwell Otto, Emily Nicole Powers, Ze Cheng
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b9378b337ed24141f6e12191011cbc9
https://doi.org/10.1096/fasebj.2018.32.1_supplement.651.9
https://doi.org/10.1096/fasebj.2018.32.1_supplement.651.9
Autor:
Emily Nicole Powers, Abdurrahman Keskin, George Maxwell Otto, Steven A. Carr, Ze Cheng, Gloria A. Brar, Marko Jovanovic, Philipp Mertins
Publikováno v:
Cell, vol 172, iss 5
To better understand the gene regulatory mechanisms that program developmental processes, we carried out simultaneous, genome-wide measurements of mRNA, translation and protein through meiotic differentiation in budding yeast. Surprisingly, we observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eefdaa5910207c7a75a0b4387c373a0
https://escholarship.org/uc/item/0wf454j5
https://escholarship.org/uc/item/0wf454j5
Autor:
Robert N. Hoover, Joy Gary, Paul S. Meltzer, Neyssa Marina, Lisa Mirabello, Irene L. Andrulis, Natalie K. Wolf, Silvia Regina Caminada de Toledo, David Thomas, Mandy L. Ballinger, Sholom Wacholder, Piero Picci, Nathan Pankratz, Meredith Yeager, Sharon A. Savage, Margaret A. Tucker, Stephen J. Chanock, Ana Patiño-García, Massimo Serra, Jay S. Wunder, Richard Gorlick, David A. Largaespada, Lee J. Helman, Nalan Gokgoz, Chand Khanna, Joseph F. Fraumeni, Donald A. Barkauskas, Julie M. Gastier-Foster, Katia Scotlandi, Maria Fernanda Amary, Claudia Maria Hattinger, Branden S. Moriarity, Logan G. Spector, Belynda Hicks, Madison T. Weg, Fernando Lecanda, Kelsie L. Becklin, Roelof Koster, Orestis A. Panagiotou, Neil E. Caporaso, George Maxwell Otto, Mitchell J. Machiela, Aurelie Vogt, Joseph Boland, Luis Sierrasesúmaga, Laurie Burdett, Adrienne M. Flanagan, Roberto Tirabosco, Zhaoming Wang, Dina Halai, Antonio Sergio Petrilli, Sean Davis
Publikováno v:
Cancer Discovery. 5:920-931
Metastasis is the leading cause of death in patients with osteosarcoma, the most common pediatric bone malignancy. We conducted a multistage genome-wide association study of osteosarcoma metastasis at diagnosis in 935 osteosarcoma patients to determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e27c5e0acaeb66ada8cc0e349e438d
https://doi.org/10.1158/2159-8290.cd-15-0125
https://doi.org/10.1158/2159-8290.cd-15-0125
Autor:
Michael A. Dyer, Rebecca S. LaRue, Branden S. Moriarity, Sam D. Molyneux, Jaime F. Modiano, Susan K. Rathe, David A. Largaespada, Luke A Manlove, Colleen L. Forster, Milcah C. Scott, George Maxwell Otto, Yi Yang, Madison T. Weg, Kwangmin Choi, Nuri A. Temiz, Stephen M. Hewitt, Rama Khokha, Natalie K. Wolf, Chand Khanna, Kevin J Holly, Eric P. Rahrmann, Aaron L. Sarver, Richard Gorlick
Publikováno v:
Nature Genetics. 47:615-624
Osteosarcomas are sarcomas of the bone, derived from osteoblasts or their precursors, with a high propensity to metastasize. Osteosarcoma is associated with massive genomic instability, making it problematic to identify driver genes using human tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3a74dc8a53564d07383b68471c9fdd
https://doi.org/10.1038/ng.3293
https://doi.org/10.1038/ng.3293