Zobrazeno 1 - 10
of 67
pro vyhledávání: '"George Makedonas"'
Autor:
Hana M El Sahly, George Makedonas, David Corry, Robert L Atmar, Abbie Bellamy, Kaitlyn Cross, Wendy A Keitel
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 16, Iss 12, Pp 3138-3145 (2020)
The immunologic mechanisms underlying the improved serologic responses to heterologous prime-boost avian influenza vaccination are unclear. An exploratory analysis of the immune responses following 1 dose of influenza A/H7N9 inactivated vaccine in su
Externí odkaz:
https://doaj.org/article/7252e15c1c02438e834c6319cf923c9f
Autor:
George Makedonas, Satish Mehta, Alexander Choukèr, Richard J. Simpson, Gailen Marshall, Jordan S. Orange, Serena Aunon-Chancellor, Scott M. Smith, Sara R. Zwart, Raymond P. Stowe, Martina Heer, Sergey Ponomarev, Alexandra Whitmire, Jean P. Frippiat, Grace L. Douglas, Stephanie S. Krieger, Hernan Lorenzi, Judith-Irina Buchheim, Geoffrey S. Ginsburg, C. Mark Ott, Meghan Downs, Duane Pierson, Natalie Baecker, Clarence Sams, Brian Crucian
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/b27e4c4ae0ea4bf2b364c4d3877f2a06
Autor:
Brian E. Crucian, Alexander Choukèr, Richard J. Simpson, Satish Mehta, Gailen Marshall, Scott M. Smith, Sara R. Zwart, Martina Heer, Sergey Ponomarev, Alexandra Whitmire, Jean P. Frippiat, Grace L. Douglas, Hernan Lorenzi, Judith-Irina Buchheim, George Makedonas, Geoffrey S. Ginsburg, C. Mark Ott, Duane L. Pierson, Stephanie S. Krieger, Natalie Baecker, Clarence Sams
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Recent studies have established that dysregulation of the human immune system and the reactivation of latent herpesviruses persists for the duration of a 6-month orbital spaceflight. It appears certain aspects of adaptive immunity are dysregulated du
Externí odkaz:
https://doaj.org/article/3004e90bcb074975994e73e64239391c
Autor:
Saimun Singla, Scott E. Wenderfer, Eyal Muscal, Anna Carmela P. Sagcal-Gironella, Jordan S. Orange, George Makedonas
Publikováno v:
Frontiers in Pediatrics, Vol 5 (2017)
BackgroundSeveral studies suggest that defects of regulatory T-cells (Tregs) and impaired cellular immunity are secondary to an imbalance between auto-aggressive T-cells and Tregs in lupus patients. Discrepancies in Tregs and effector T-cells (Teff)
Externí odkaz:
https://doaj.org/article/ea729a38e80a4a6ea9c74aa215394f3f
Autor:
Sanjana Mahapatra, Emily M Mace, Charles G Minard, Lisa R Forbes, Alexander Vargas-Hernandez, Teresa K Duryea, George Makedonas, Pinaki P Banerjee, William T Shearer, Jordan S Orange
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181134 (2017)
Natural killer (NK) cells are critical in immune defense against infected, stressed or transformed cells. Their function is regulated by the heterogeneous expression of a wide array of surface receptors that shape its phenotypic diversity. Although N
Externí odkaz:
https://doaj.org/article/c93cb059f3524b269ae4a9eb643939e4
Autor:
Korey R Demers, George Makedonas, Marcus Buggert, Michael A Eller, Sarah J Ratcliffe, Nilu Goonetilleke, Chris K Li, Leigh Anne Eller, Kathleen Rono, Lucas Maganga, Sorachai Nitayaphan, Hannah Kibuuka, Jean-Pierre Routy, Mark K Slifka, Barton F Haynes, Andrew J McMichael, Nicole F Bernard, Merlin L Robb, Michael R Betts
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005805 (2016)
The loss of HIV-specific CD8+ T cell cytolytic function is a primary factor underlying progressive HIV infection, but whether HIV-specific CD8+ T cells initially possess cytolytic effector capacity, and when and why this may be lost during infection,
Externí odkaz:
https://doaj.org/article/cc71a55609f4438dab295eef02ccb356
Autor:
Andrew R. DiNardo, Anna M. Mandalakas, Gugu Maphalala, Godwin Mtetwa, Temhlanga Mndzebele, Piluca Ustero, Makhosazana Hlatshwayo, Emily M. Mace, Jordan S. Orange, George Makedonas
Publikováno v:
Mediators of Inflammation, Vol 2016 (2016)
Introduction. Our objective is to understand how HIV infection increases the risk of progression from latent tuberculosis (TB) to active disease. We understand now that immunity is a balance of competing immune responses by multiple cell types. Since
Externí odkaz:
https://doaj.org/article/715aaa7838084f958f39a24931d2a45b
Autor:
Adam R Hersperger, Florencia Pereyra, Martha Nason, Korey Demers, Prameet Sheth, Lucy Y Shin, Colin M Kovacs, Benigno Rodriguez, Scott F Sieg, Leia Teixeira-Johnson, Debbie Gudonis, Paul A Goepfert, Michael M Lederman, Ian Frank, George Makedonas, Rupert Kaul, Bruce D Walker, Michael R Betts
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000917 (2010)
Many immune correlates of CD8(+) T-cell-mediated control of HIV replication, including polyfunctionality, proliferative ability, and inhibitory receptor expression, have been discovered. However, no functional correlates using ex vivo cells have been
Externí odkaz:
https://doaj.org/article/22391fded80246119c553a0c73d1d4db
Autor:
George Makedonas, Natalie Hutnick, Danielle Haney, Alexandra C Amick, Jay Gardner, Gabriela Cosma, Adam R Hersperger, Douglas Dolfi, E John Wherry, Guido Ferrari, Michael R Betts
Publikováno v:
PLoS Pathogens, Vol 6, Iss 3, p e1000798 (2010)
The prevailing paradigm of T lymphocyte control of viral replication is that the protective capacity of virus-specific CD8(+) T cells is directly proportional to the number of functions they can perform, with IL-2 production capacity considered criti
Externí odkaz:
https://doaj.org/article/e777a749e175444e93737a06836a209d
Autor:
Zachary Salas, Rachael Miller, Kathleen McMonigal, George Makedonas, Kimesha Calaway, Gail P. Perusek, Russell Valentine, Kathleen Rubins, Kris Lehnhardt, Michael Hopkins, Benjamin Easter, Mayra Nelman-Gonzalez, Stephanie Krieger, Brian Crucian
Publikováno v:
Life Sciences in Space Research. 31:29-33
During long duration orbital space missions, astronauts experience immune system dysregulation, the persistent reactivation of latent herpesviruses, and some degree of clinical incidence. During planned NASA ‘Artemis’ deep space missions the stre