Zobrazeno 1 - 6
of 6
pro vyhledávání: '"George M.H. Birchenough"'
Autor:
George M.H. Birchenough, Bjoern O. Schroeder, Sinan Sharba, Liisa Arike, Christian V. Recktenwald, Fabiola Puértolas-Balint, Mahadevan V. Subramani, Karl T. Hansson, Bahtiyar Yilmaz, Sara K. Lindén, Fredrik Bäckhed, Gunnar C. Hansson
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112084- (2023)
Summary: Intestinal mucus barriers normally prevent microbial infections but are sensitive to diet-dependent changes in the luminal environment. Here we demonstrate that mice fed a Western-style diet (WSD) suffer regiospecific failure of the mucus ba
Externí odkaz:
https://doaj.org/article/a96200ad06eb4e86aa3f1f03dd90aee0
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108949- (2021)
Summary: The colon epithelium is a primary point of interaction with the microbiome and is regenerated by a few rapidly cycling colonic stem cells (CSCs). CSC self-renewal and proliferation are regulated by growth factors and the presence of bacteria
Externí odkaz:
https://doaj.org/article/ec39f11b3cdd4352a1b152250bd69f70
Autor:
Elisabeth E.L. Nyström, George M.H. Birchenough, Sjoerd van der Post, Liisa Arike, Achim D. Gruber, Gunnar C. Hansson, Malin E.V. Johansson
Publikováno v:
EBioMedicine, Vol 33, Iss , Pp 134-143 (2018)
Many epithelial surfaces of the body are covered with protective mucus, and disrupted mucus homeostasis is coupled to diseases such as ulcerative colitis, helminth infection, cystic fibrosis, and chronic obstructive lung disease. However, little is k
Externí odkaz:
https://doaj.org/article/809cdfdc1c2844f688f730b938c81b5c
Publikováno v:
Journal of Biological Chemistry
Publikováno v:
Cell Host & Microbe
Autor:
Joana K. Volk, Elisabeth E.L. Nyström, Sjoerd van der Post, Beatriz M. Abad, Bjoern O. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, Malin E.V. Johansson, Gunnar C. Hansson, George M.H. Birchenough
Publikováno v:
The Journal of Experimental Medicine
The inner mucus layer (IML) is a critical barrier that protects the colonic epithelium from luminal threats and inflammatory bowel disease. Innate immune signaling is thought to regulate IML formation via goblet cell Nlrp6 inflammasome activity that