Zobrazeno 1 - 10 of 37 pro vyhledávání: '"George M. Steinberg"'
1
Phosphonofluoridate inhibition of acetylcholinesterase: an exceptionally rapid reactant
Autor: George M. Steinberg, Morton L. Mednick
Publikováno v: Bioorganic Chemistry. 3:81-90
Both isomers of [3.6-dioxa-(8-(2,4-dinitrophenoxy))octyl] methylphosphono-fluoridate (I) react rapidly with eel acetylcholinesterase. At pH 6.61 and 25°C, the reaction rate constants for the fast and slow isomers are 3 × 109 and 5 × 107 M−1 min
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f4625bc0ce8ca67e7455e683aaeba65
https://doi.org/10.1016/0045-2068(74)90032-7
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2
Comparison of the effect of the reversible inhibitor hexamethylenebis-[dimethyl-(3-phthalimidopropyl) ammonium bromide] upon the hydrolysis of several substrates by acetylcholinesterase
Autor: George M. Steinberg, Joseph W. Amshey
Publikováno v: Archives of Biochemistry and Biophysics. 175:618-626
The characteristics of the inhibition of acetylcholinesterase by hexamethylenebis-[dimethyl-(3-phthalimidopropyl) ammonium bromide] are both qualitatively and quantitatively different when examined in the presence of the substrates acetylcholine and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::451f857b199c5f306f3eb88b734617a4
https://doi.org/10.1016/0003-9861(76)90552-x
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3
Synthesis of oxirnes. IV. 2-pyridinealdoxime methiodides from 2-picoline methiodides
Autor: Arthur B. Ash, Calvin L. Stevens, Anica Markovac, Brennie E. Hackley, George M. Steinberg
Publikováno v: Journal of Heterocyclic Chemistry. 14:19-26
The Ortoleva-King-Krohnke sequence was used to prepare substituted 2-pyridinealdoxime methiodides. The methodology was extended to prepare three analogs in which two molecules of 5-hydroxy-2-pyridinealdoxime methiodide were coupled through the 5-posi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d2b2fb8006e01a1c75878667f45ef87
https://doi.org/10.1002/jhet.5570140104
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4
Spontaneous reactivation of acetylcholinesterase following organophosphate inhibition
Autor: Karl W. Lanks, Claire N. Lieske, Clarence A. Broomfield, George M. Steinberg, Joseph W. Hovanec
Publikováno v: Biochimica et Biophysica Acta (BBA) - Enzymology. 483:312-319
The first kinetic studies on the spontaneous reactivation of Sarin-inhibited acetylcholinesterase (ascetylcholine hydrolase, EC 3.1.1.7) are reported. With increasing pH the extent of reactivation increases while the observed rate constant decreases.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c42022d3555acc103e4ce09db2fba1c7
https://doi.org/10.1016/0005-2744(77)90059-6
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7
The reaction of tris-(choline chloride) phosphate with eel cholinesterase
Autor: Joseph W. Amshey, George M. Steinberg
Publikováno v: Biochimica et Biophysica Acta (BBA) - Enzymology. 284:157-163
Tris-(choline chloride) phosphate (TCCP) has been observed to slowly and progressively inhibit eel acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7). The kinetics of the inhibition reaction are consistent with a mechanism involving binding o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a02db6bc3261eb92bee56b577af11a
https://doi.org/10.1016/0005-2744(72)90054-x
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