Zobrazeno 1 - 10
of 18
pro vyhledávání: '"George M. Maniatis"'
Publikováno v:
British Journal of Haematology. 66:379-383
We have carried out DNA haplotype analysis of 69 beta-thalassaemia patients in Greece and 42 of the parents using seven standard polymorphic sites. Our data show a high degree of heterogeneity of the chromosomal background in which beta-thalassaemia
Autor:
Lambrini Psiouri, Vassilis G. Gorgoulis, George M. Maniatis, Gerassimos E. Voutsinas, Liliana Puiu, Anastasia Apostolidou, Eftichia Petrakou, Aglaia Athanassiadou, Adamantia Papachatzopoulou, Athanassios Kotsinas, Evangelos Tzoracoeleftherakis
Publikováno v:
Cancer Letters. 194:91-97
Fas (APO-1/CD95) is a transmembrane receptor protein involved in cell death signaling. Fas receptor and ligand are both expressed in breast cancer cells, however these cells are resistant to apoptosis. Fas gene mutations were detected in hematologica
Autor:
George M. Maniatis, Richard A. Gibbs, Nicholas C. Zoumbos, Aglaia Athanassiadou, Adamandia Papachatzopoulou
Publikováno v:
British Journal of Haematology. 88:307-310
A thymidine deletion at position +10 of the 5' untranslated region of the beta-globin gene was detected in a beta-thalassaemia intermedia patient carrying a beta(0)39 stop codon mutation on the other chromosome; this new mutation, +10(-T), was detect
Autor:
Paul A. Marks, Phyllis A. Shaw, Roberto Gambari, Shigeru Sassa, Roberta C. Reuben, Eitan Fibach, George M. Maniatis, Richard A. Rifkind
Publikováno v:
Proceedings of the National Academy of Sciences. 76:1906-1910
Previous studies demonstrated that 12-O-tetradecanoyl-phorbol-13-acetate (TPA), a tumor promoter, is a potent inhibitor of inducer-mediated differentiation of murine erythroleukemia cells. Inhibition of cell differentiation was associated with inhibi
Publikováno v:
Blood. 47:767-776
There is decreased beta-globin production in beta-thalassemic reticulocytes and nucleated erythroid cells. In this study, we have examined whether unbalanced globin synthesis is expressed at all stages of human erythroid cell maturation. In order to
Autor:
Sol Spiegelman, Paul A. Marks, Clayton Natta, D. L. Kacian, Francesco Ramirez, George M. Maniatis, Arthur Bank, Roberto Gambino
Publikováno v:
Annals of the New York Academy of Sciences. 241:247-252
Publikováno v:
Journal of Clinical Investigation. 58:1419-1427
Human globin messenger RNA (mRNA) prepared from erythroid cells of patients with sickle cell anemia has been translated in Xenopus laevis oocytes. Addition of hemin to the injected mRNA causes total globin synthesis to increase and the ratio of alpha
Autor:
Masaaiki Terada, Richard A. Rifkind, Paul A. Marks, Yair Gazitt, Uri Nudel, Roberta C. Reuben, Arthur Bank, Eitan Fibach, George M. Maniatis, Jane E. Salmon
Publikováno v:
In Vitro. 14:155-161
Studies are described employing two erythropoietic systems to elucidate regulatory mechanisms that control both normal erythropoiesis and erythroid differentiation of transformed hemopoietic precursors. Evidence is provided suggesting that normal ery
Autor:
George M. Maniatis, Vernon M. Ingram
Publikováno v:
Developmental Biology. 27:580-583
InRana catesbeiana tadpoles increased erythropoietic activity resulting from phenylhydrazine-induced hemolytic anemia does not lead to synthesis of frog hemoglobin. Administration of thyroxine to animals recovering from phenylhydrazine-induced anemia
Publikováno v:
Proceedings of the National Academy of Sciences. 70:3189-3194
The effect of erythropoietin on cultured erythroid precursor cells from 13-day mouse-fetal livers was examined. Within 1 hr, erythropoietin causes a 2- to 3-fold stimulation of uridine incorporation into RNA by these cells. The types of RNA preferent