Zobrazeno 1 - 10
of 56
pro vyhledávání: '"George M. Hughes"'
Autor:
Dušan Petrović, James S. Scott, Michael S. Bodnarchuk, Olivier Lorthioir, Scott Boyd, George M. Hughes, Jordan Lane, Allan Wu, David Hargreaves, James Robinson, Jens Sadowski
Publikováno v:
Journal of chemical information and modeling. 62(16)
ROS1 rearrangements account for 1-2% of non-small cell lung cancer patients, yet there are no specifically designed, selective ROS1 therapies in the clinic. Previous knowledge of potent ROS1 inhibitors with selectivity over TrkA, a selected antitarge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c3f840f353a4182bae8a31782f88c5
https://pubmed.ncbi.nlm.nih.gov/35920716
https://pubmed.ncbi.nlm.nih.gov/35920716
Autor:
Emilia Sicilia, Samya Banerjee, Hannah E. Bridgewater, James P. C. Coverdale, Ben Breeze, Fortuna Ponte, Guy J. Clarkson, Ji-Inn Song, George M. Hughes, Carlos Sanchez-Cano, Wen-Ying Zhang, Peter J. Sadler
Publikováno v:
Chemical Science
Organometallic complexes with novel activation mechanisms are attractive anticancer drug candidates. Here, we show that half-sandwich iodido cyclopentadienyl iridium(iii) azopyridine complexes exhibit potent antiproliferative activity towards cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cabaf13d6a6e11c6c6548f5dc141f413
https://pubmed.ncbi.nlm.nih.gov/34094073
https://pubmed.ncbi.nlm.nih.gov/34094073
Autor:
Jessica M. Hearn, Peter J. Sadler, Zhe Liu, George M. Hughes, Alison F. Munro, Neil O. Carragher, Belén Rubio-Ruiz, Isolda Romero-Canelón
Publikováno v:
Hearn, J M, Hughes, G M, Romero-Canelón, I, Munro, A, Rubio Ruiz, B, Liu, Z, Carragher, N & Sadler, P J 2017, ' Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action ', Metallomics . https://doi.org/10.1039/C7MT00242D
Resistance to platinum drugs (used in >50% of cancer chemotherapies) is a clinical problem. Other precious metal complexes with distinct mechanisms of action might overcome this. Half-sandwich organometallic complexes containing arene or cyclopentadi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f890d12d9a3d886a66a8cfa68faa63e
https://pubmed.ncbi.nlm.nih.gov/29131211
https://pubmed.ncbi.nlm.nih.gov/29131211
Autor:
George M. Hughes
Publikováno v:
Italian Journal of Zoology. 65:425-429
The low surface area of Latimeria gills has been confirmed for a range of body sizes from 450 gr to 80 kg. This is an indication of an inactive mode of life as has now been observed from submersibles. The gill septa indicate that Latimeria and lungfi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b53bd9664b2f813fc6a275ff807749cf
https://doi.org/10.1080/11250009809386859
https://doi.org/10.1080/11250009809386859
Publikováno v:
AEG News; Mar2020, Vol. 63 Issue 1, p19-28, 10p
Publikováno v:
Journal of Experimental Biology. 121:27-42
In order to study the dependence of the dimensions of the respiratory apparatus on body size and to provide a morphometric basis for the analysis of branchial gas exchange function, the gills of 12 specimens of Scyliorhinus stellaris L., weighing 0·
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a60838e47b408b88b23e1ab26402fad
https://doi.org/10.1242/jeb.121.1.27
https://doi.org/10.1242/jeb.121.1.27
Publikováno v:
Journal of Experimental Biology. 123:27-41
Calculations of the effective O2 conductance (diffusing capacity or transfer factor, Deff) of fish gills, obtained from experimental data on gill O2 exchange, were compared with the predicted O2-exchange properties of gill models based on morphometri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f631f8755c6abb6e49f9c5e4626dce06
https://doi.org/10.1242/jeb.123.1.27
https://doi.org/10.1242/jeb.123.1.27
Publikováno v:
Journal of Hydrology. 43:67-78
The magnitude and direction of groundwater flux in the bottom sediments of Lake Michigan were deduced from measurements made during three shipboard cruises between 1973 and 1975. These factors affect the geochemical environment of the sediments and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abf8856fee60e4c2a61ca7462509436a
https://doi.org/10.1016/0022-1694(79)90165-3
https://doi.org/10.1016/0022-1694(79)90165-3
Autor:
W. Arthur. White, George M. Hughes, Robert A. Griffin, Rodney R. Ruch, Neil F. Shimp, John D. Steele
Publikováno v:
Environmental Science & Technology. 10:1262-1268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e5c609bda511345c1c19df76f5ac69
https://doi.org/10.1021/es60123a006
https://doi.org/10.1021/es60123a006
Publikováno v:
Japanese Journal of Ichthyology. 35:453-465
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13f5f0b482a0aaf8fa8ae0b726e9f467
https://doi.org/10.1007/bf02905503
https://doi.org/10.1007/bf02905503