Zobrazeno 1 - 10
of 10
pro vyhledávání: '"George M Lawless"'
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2334 (2008)
ALS8 is caused by a dominant mutation in an evolutionarily conserved protein, VAPB (vesicle-associated membrane protein (VAMP)-associated membrane protein B)/ALS8). We have established a fly model of ALS8 using the corresponding mutation in Drosophil
Externí odkaz:
https://doaj.org/article/c166d20aef8648f983566afa668d8cdc
Publikováno v:
Human Molecular Genetics
Hyperphosphorylation of tau at multiple sites has been implicated in the formation of neurofibrillary tangles in Alzheimer's disease; however, the relationship between toxicity and phosphorylation of tau has not been clearly elucidated. Putative tau
Autor:
George M. Lawless, Tzu-Kang Sang, Martina Wiedau-Pazos, Daniel H. Geschwind, Harry V. Vinters, Justine Pomakian, Jiankai Liu, Robert W. Berry, Hyun S. Oh, George R. Jackson, Stanislav L. Karsten, Lester I. Binder, Cordula Schulz, Soma Sengupta, Shreyasi Chatterjee, Lauren T. Gehman, Koon-Sea Hui
Publikováno v:
Neuron. 51:549-560
Summary Neurofibrillary tangles (NFT) containing tau are a hallmark of neurodegenerative diseases, including Alzheimer's disease (AD). NFT burden correlates with cognitive decline and neurodegeneration in AD. However, little is known about mechanisms
Autor:
Jose Segovia, George M. Lawless, Allan J. Tobin, Michael Brenner, Niranjala J.K. Tillakaratne
Publikováno v:
Journal of Neurochemistry. 63:1218-1225
C6 cells express proteins and mRNAs that are characteristic of both glia and neurons. Agents that increase intracellular levels of cyclic AMP (cAMP) decrease the enzymatic activity of glutamate decarboxylase (GAD), a neuronal marker, and the mRNA lev
Autor:
George M. Lawless, Yosephine P. Lumintang, Vanessa Nunez, Hakeem O. Lawal, Angel Barajas, Khadij Assani, David E. Krantz, Ciara A. Martin
The neurodegenerative effects of Parkinson's disease (PD) are marked by a selective loss of dopaminergic (DA) neurons. Epidemiological studies suggest that chronic exposure to the pesticide paraquat may increase the risk for PD and DA cell loss. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674f5ce8cbd1ffd1ef936f5c9f7685bd
https://europepmc.org/articles/PMC4264678/
https://europepmc.org/articles/PMC4264678/
Autor:
Chou Mt, Nigel T. Maidment, Hakeem O. Lawal, George M. Lawless, Brian Z. Huang, Lam Ha, Terrell A, Shahi, David E. Krantz, Traci Biedermann, Jang J, Hadi R, Djapri C, Logan Roberts
Publikováno v:
Molecular psychiatry
Molecular psychiatry, vol 19, iss 2
Molecular psychiatry, vol 19, iss 2
Small molecules that increase the presynaptic function of aminergic cells may provide neuroprotection in Parkinson’s disease as well as treatments for attention deficit hyperactivity disorder (ADHD) and depression. Model genetic organisms such as D
Autor:
Felix E. Schweizer, George M. Lawless, Peyman Golshani, George R. Jackson, Anuradha Ratnaparkhi
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2334 (2008)
PloS one, vol 3, iss 6
PLoS ONE
PloS one, vol 3, iss 6
PLoS ONE
ALS8 is caused by a dominant mutation in an evolutionarily conserved protein, VAPB (vesicle-associated membrane protein (VAMP)-associated membrane protein B)/ALS8). We have established a fly model of ALS8 using the corresponding mutation in Drosophil
Autor:
Nigel T. Maidment, David E. Krantz, Hui-Yun Chang, George R. Jackson, Tzu-Kang Sang, Lisa Mee, Larry C. Ackerson, Anuradha Ratnaparkhi, George M. Lawless
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(5)
Mutations in human parkin have been identified in familial Parkinson's disease and in some sporadic cases. Here, we report that expression of mutant but not wild-type human parkin inDrosophilacauses age-dependent, selective degeneration of dopaminerg
Autor:
Supriya Srinivasan, Richard W. Olsen, Allan J. Tobin, Christopher J. Nichols, George M. Lawless
Publikováno v:
The Journal of biological chemistry. 274(38)
Two invariant tryptophan residues on the N-terminal extracellular region of the rat alpha1 subunit, Trp-69 and Trp-94, are critical for the assembly of the GABA(A) (gamma-aminobutyric acid, type A) receptor into a pentamer. These tryptophans are comm
Publikováno v:
Immunogenetics. 28:365-373
The genes encoding three invariant components of the human T-cell antigen receptor, the CD3 delta, gamma, and epsilon chains, are located on human chromosome 11 at band q23. We isolated cosmid clones containing the human CD3 delta and gamma chain gen