Zobrazeno 1 - 10
of 410
pro vyhledávání: '"George M, Shaw"'
Autor:
Ellie Mainou, Stella J. Berendam, Veronica Obregon-Perko, Emilie A. Uffman, Caroline T. Phan, George M. Shaw, Katharine J. Bar, Mithra R. Kumar, Emily J. Fray, Janet M. Siliciano, Robert F. Siliciano, Guido Silvestri, Sallie R. Permar, Genevieve G. Fouda, Janice McCarthy, Ann Chahroudi, Jessica M. Conway, Cliburn Chan
Publikováno v:
Epidemics, Vol 48, Iss , Pp 100780- (2024)
While the benefits of early antiretroviral therapy (ART) initiation in perinatally infected infants are well documented, early initiation is not always possible in postnatal pediatric HIV infections. The timing of ART initiation is likely to affect t
Externí odkaz:
https://doaj.org/article/60d2aef43b0643d1af9bb0c95351b590
Autor:
Venkata S. Bollimpelli, Pradeep B. J Reddy, Sailaja Gangadhara, Tysheena P. Charles, Samantha L. Burton, Gregory K. Tharp, Tiffany M. Styles, Celia C. Labranche, Justin C. Smith, Amit A. Upadhyay, Anusmita Sahoo, Traci Legere, Ayalnesh Shiferaw, Vijayakumar Velu, Tianwei Yu, Mark Tomai, John Vasilakos, Sudhir P. Kasturi, George M. Shaw, David Montefiori, Steven E. Bosinger, Pamela A. Kozlowski, Bali Pulendran, Cynthia A. Derdeyn, Eric Hunter, Rama R. Amara
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Route of immunization can markedly influence the quality of immune response. Here, we show that intradermal (ID) but not intramuscular (IM) modified vaccinia Ankara (MVA) vaccinations provide protection from acquisition of intravaginal tier2
Externí odkaz:
https://doaj.org/article/101d7faa095245b791894f88734b70d5
Publikováno v:
Viruses, Vol 16, Iss 7, p 1014 (2024)
We recently demonstrated that Simian–HIV (SHIV)-infected neonate rhesus macaques (RMs) generated heterologous HIV-1 neutralizing antibodies (NAbs) with broadly-NAb (bNAb) characteristics at a higher frequency compared with their corresponding dam.
Externí odkaz:
https://doaj.org/article/12cfb65587624ee0bc0ebbb0487de846
Autor:
Sandra Dross, Rasika Venkataraman, Shabnum Patel, Meei-Li Huang, Catherine M. Bollard, Margherita Rosati, George N. Pavlakis, Barbara K. Felber, Katharine J. Bar, George M. Shaw, Keith R. Jerome, James I. Mullins, Hans-Peter Kiem, Deborah Heydenburg Fuller, Christopher W. Peterson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
HIV-specific T cells are necessary for control of HIV-1 replication but are largely insufficient for viral clearance. This is due in part to these cells’ recognition of immunodominant but variable regions of the virus, which facilitates viral escap
Externí odkaz:
https://doaj.org/article/23b8184a8d714211a8e14e49ff22762b
Autor:
Ashley N. Nelson, Maria Dennis, Jesse F. Mangold, Katherine Li, Pooja T. Saha, Kenneth Cronin, Kaitlyn A. Cross, Amit Kumar, Riley J. Mangan, George M. Shaw, Katharine J. Bar, Barton Haynes, Anthony M. Moody, S. Munir Alam, Justin Pollara, Michael G. Hudgens, Koen K. A. Van Rompay, Kristina De Paris, Sallie R. Permar
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract The development of a maternal HIV vaccine to synergize with current antiretroviral drug prophylaxis can overcome implementation challenges and further reduce mother-to-child transmission (MTCT) of HIV. Both the epitope-specificity and autolo
Externí odkaz:
https://doaj.org/article/0b0d44ecc1e745dcb581c54bee8b031d
Autor:
Bhavna Hora, Hui Li, Xiaoying Shen, Mitchell Martin, Yue Chen, Madison Berry, Tyler Evangelous, Andrew N. Macintyre, Aria Arus-Altuz, Shuyi Wang, Ajay Singh, Chengyan Zhao, Nicole De Naeyer, Todd DeMarco, Cindy Kuykendall, Thaddeus Gurley, Kevin O. Saunders, Thomas Denny, M. Anthony Moody, John Misamore, Mark G. Lewis, Kevin Wiehe, Derek W. Cain, David C. Montefiori, George M. Shaw, Wilton B. Williams
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112255- (2023)
Summary: Infants and children infected with human immunodeficiency virus (HIV)-1 have been shown to develop neutralizing antibodies (nAbs) against heterologous HIV-1 strains, characteristic of broadly nAbs (bnAbs). Thus, having a neonatal model for t
Externí odkaz:
https://doaj.org/article/7dce7418af584710aa80977788fdbcd6
Autor:
Frederic Bibollet-Ruche, Ronnie M. Russell, Wenge Ding, Weimin Liu, Yingying Li, Kshitij Wagh, Daniel Wrapp, Rumi Habib, Ashwin N. Skelly, Ryan S. Roark, Scott Sherrill-Mix, Shuyi Wang, Juliette Rando, Emily Lindemuth, Kendra Cruickshank, Younghoon Park, Rachel Baum, John W. Carey, Andrew Jesse Connell, Hui Li, Elena E. Giorgi, Ge S. Song, Shilei Ding, Andrés Finzi, Amanda Newman, Giovanna E. Hernandez, Emily Machiele, Derek W. Cain, Katayoun Mansouri, Mark G. Lewis, David C. Montefiori, Kevin J. Wiehe, S. Munir Alam, I-Ting Teng, Peter D. Kwong, Raiees Andrabi, Laurent Verkoczy, Dennis R. Burton, Bette T. Korber, Kevin O. Saunders, Barton F. Haynes, Robert J. Edwards, George M. Shaw, Beatrice H. Hahn
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT HIV-1 and its SIV precursors share a broadly neutralizing antibody (bNAb) epitope in variable loop 2 (V2) at the envelope glycoprotein (Env) trimer apex. Here, we tested the immunogenicity of germ line-targeting versions of a chimpanzee SIV
Externí odkaz:
https://doaj.org/article/3b93383f6dad4c28967afedad78671dd
Autor:
Lindsey J. Plenderleith, Weimin Liu, Yingying Li, Dorothy E. Loy, Ewan Mollison, Jesse Connell, Ahidjo Ayouba, Amandine Esteban, Martine Peeters, Crickette M. Sanz, David B. Morgan, Nathan D. Wolfe, Markus Ulrich, Andreas Sachse, Sébastien Calvignac-Spencer, Fabian H. Leendertz, George M. Shaw, Beatrice H. Hahn, Paul M. Sharp
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Plasmodium malariae is a cause of malaria in humans and related species have been identified in non-human primates. Here, the authors use genomic analyses to establish that human P. malariae arose from a host switch of an ape parasite whilst a specie
Externí odkaz:
https://doaj.org/article/fb4e602288f4471d94b66c97f143695e
Autor:
Weimin Liu, Ronnie M. Russell, Frederic Bibollet-Ruche, Ashwin N. Skelly, Scott Sherrill-Mix, Drew A. Freeman, Regina Stoltz, Emily Lindemuth, Fang-Hua Lee, Sarah Sterrett, Katharine J. Bar, Nathaniel Erdmann, Sigrid Gouma, Scott E. Hensley, Thomas Ketas, Albert Cupo, Victor M. Cruz Portillo, John P. Moore, Paul D. Bieniasz, Theodora Hatziioannou, Greer Massey, Mary-Beth Minyard, Michael S. Saag, Randall S. Davis, George M. Shaw, William J. Britt, Sixto M. Leal, Paul Goepfert, Beatrice H. Hahn
Publikováno v:
Emerging Infectious Diseases, Vol 27, Iss 9, Pp 2454-2458 (2021)
Not all persons recovering from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection develop SARS-CoV-2–specific antibodies. We show that nonseroconversion is associated with younger age and higher reverse transcription PCR cycle
Externí odkaz:
https://doaj.org/article/64493f6531fd464393624fb9de922352
Autor:
Nicole Frumento, Alexis Figueroa, Tingchang Wang, Muhammad N. Zahid, Shuyi Wang, Guido Massaccesi, Georgia Stavrakis, James E. Crowe Jr, Andrew I. Flyak, Hongkai Ji, Stuart C. Ray, George M. Shaw, Andrea L. Cox, Justin R. Bailey
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
A prophylactic hepatitis C virus (HCV) vaccine that elicits neutralizing antibodies could be key to HCV eradication. However, the genetic and antigenic properties of HCV envelope (E1E2) proteins capable of inducing anti-HCV broadly neutralizing antib
Externí odkaz:
https://doaj.org/article/596058b1e58e410a97427a1e7246375a