Zobrazeno 1 - 10
of 737
pro vyhledávání: '"George M, Church"'
Autor:
Braden T. Tierney, Jonathan Foox, Krista A. Ryon, Daniel Butler, Namita Damle, Benjamin G. Young, Christopher Mozsary, Kristina M. Babler, Xue Yin, Yamina Carattini, David Andrews, Alexander G. Lucaci, Natasha Schaefer Solle, Naresh Kumar, Bhavarth Shukla, Dušica Vidović, Benjamin Currall, Sion L. Williams, Stephan C. Schürer, Mario Stevenson, Ayaaz Amirali, Cynthia Campos Beaver, Erin Kobetz, Melinda M. Boone, Brian Reding, Jennifer Laine, Samuel Comerford, Walter E. Lamar, John J. Tallon, Jeremy Wain Hirschberg, Jacqueline Proszynski, Gabriel Al Ghalith, Kübra Can Kurt, Mark E. Sharkey, George M. Church, George S. Grills, Helena M. Solo-Gabriele, Christopher E. Mason
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Wastewater is a geospatially- and temporally-linked microbial fingerprint of a given population, making it a potentially valuable tool for tracking public health across locales and time. Here, we integrate targeted and bulk RNA sequencing (N
Externí odkaz:
https://doaj.org/article/e0c84d08c6104aac859de15f2159b913
Autor:
Erkin Kuru, Jonathan Rittichier, Helena de Puig, Allison Flores, Subhrajit Rout, Isaac Han, Abigail E. Reese, Thomas M. Bartlett, Fabio De Moliner, Sylvie G. Bernier, Jason D. Galpin, Jorge Marchand, William Bedell, Lindsey Robinson-McCarthy, Christopher A. Ahern, Thomas G. Bernhardt, David Z. Rudner, James J. Collins, Marc Vendrell, George M. Church
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Binding-activated optical sensors are powerful tools for imaging, diagnostics, and biomolecular sensing. However, biosensor discovery is slow and requires tedious steps in rational design, screening, and characterization. Here we report on a
Externí odkaz:
https://doaj.org/article/8c008f8b3019484da6521bb74160e592
Autor:
Lindsay A. Rutter, Matthew J. MacKay, Henry Cope, Nathaniel J. Szewczyk, JangKeun Kim, Eliah Overbey, Braden T. Tierney, Masafumi Muratani, Ben Lamm, Daniela Bezdan, Amber M. Paul, Michael A. Schmidt, George M. Church, Stefania Giacomello, Christopher E. Mason
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Common and rare alleles are now being annotated across millions of human genomes, and omics technologies are increasingly being used to develop health and treatment recommendations. However, these alleles have not yet been systematically cha
Externí odkaz:
https://doaj.org/article/432fef0373e34d608e1135e3084c96bc
Autor:
Andrew T. McKenzie, Ariel Zeleznikow-Johnston, Jordan S. Sparks, Oge Nnadi, John Smart, Keith Wiley, Michael A. Cerullo, Aschwin de Wolf, Francesca Minerva, Ramón Risco, George M. Church, João Pedro de Magalhães, Emil F. Kendziorra
Publikováno v:
Frontiers in Medical Technology, Vol 6 (2024)
When faced with the prospect of death, some people would prefer a form of long-term preservation that may allow them to be restored to healthy life in the future, if technology ever develops to the point that this is feasible and humane. Some believe
Externí odkaz:
https://doaj.org/article/31441b0faf144af7be78428e5b204c57
Autor:
Jelena Ulicevic, Zhihao Shao, Olga Jasnovidova, Annkatrin Bressin, Martyna Gajos, Alex HM Ng, Siddharth Annaldasula, David Meierhofer, George M Church, Volker Busskamp, Andreas Mayer
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 7, Pp 767-798 (2024)
Abstract Static gene expression programs have been extensively characterized in stem cells and mature human cells. However, the dynamics of RNA isoform changes upon cell-state-transitions during cell differentiation, the determinants and functional c
Externí odkaz:
https://doaj.org/article/f7e98ee836cc43f4bf04fbbaca9a7c0e
Autor:
Jessie Poquérusse, Casey Lance Brown, Camille Gaillard, Chris Doughty, Love Dalén, Austin J. Gallagher, Matthew Wooller, Nikita Zimov, George M. Church, Ben Lamm, Eriona Hysolli
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Interest continues to grow in Arctic megafaunal ecological engineering, but, since the mass extinction of megafauna ~ 12–15 ka, key physiographic variables and available forage continue to change. Here we sought to assess the extent to whi
Externí odkaz:
https://doaj.org/article/90ca12e286254887bd5d0865045a4352
Autor:
Zezhong Zheng, Lei Xu, Yangbin Gao, Hongwei Dou, Yixuan Zhou, Xu Feng, Xiangjun He, Zhen Tian, Lingling Song, Guolong Mo, Jiapan Hu, Hongye Zhao, Hongjiang Wei, George M. Church, Luhan Yang
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 7 (2024)
ABSTRACT African swine fever (ASF) is a highly fatal viral disease that poses a significant threat to domestic pigs and wild boars globally. In our study, we aimed to explore the potential of a multiplexed CRISPR-Cas system in suppressing ASFV replic
Externí odkaz:
https://doaj.org/article/aa728c5685664910bbb4738257374ead
Autor:
Andrea L. Smidler, Eryney Marrogi, Jamie Kauffman, Douglas G. Paton, Kathleen A. Westervelt, George M. Church, Kevin M. Esvelt, W. Robert Shaw, Flaminia Catteruccia
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Rapid spread of insecticide resistance among anopheline mosquitoes threatens malaria elimination efforts, necessitating development of alternative vector control technologies. Sterile insect technique (SIT) has been successfully implemented
Externí odkaz:
https://doaj.org/article/640c6f425cae457c97da6c8d1fada4b4
Publikováno v:
eLife, Vol 12 (2024)
Recombinant adeno-associated viruses (rAAVs) are the predominant gene therapy vector. Several rAAV vectored therapies have achieved regulatory approval, but production of sufficient rAAV quantities remains difficult. The AAV Rep proteins, which are e
Externí odkaz:
https://doaj.org/article/fc3d27322d8842f3ac88f95d8b811992
Autor:
Annesha Sengupta, Anindita Bandyopadhyay, Debolina Sarkar, John I. Hendry, Max G. Schubert, Deng Liu, George M. Church, Costas D. Maranas, Himadri B. Pakrasi
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Cyanobacteria are photosynthetic organisms that have garnered significant recognition as potential hosts for sustainable bioproduction. However, their complex regulatory networks pose significant challenges to major metabolic engineering eff
Externí odkaz:
https://doaj.org/article/5967109df3564918935e1b8fda0efbac