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pro vyhledávání: '"George Lo Huang"'
Autor:
Pengwen Chen, Wenqian Yang, Koji Nagaoka, George Lo Huang, Takuya Miyazaki, Taehun Hong, Shangwei Li, Kazunori Igarashi, Kazuyoshi Takeda, Kazuhiro Kakimi, Kazunori Kataoka, Horacio Cabral
Publikováno v:
Advanced Science, Vol 10, Iss 10, Pp n/a-n/a (2023)
Abstract Treatment of immunologically cold tumors is a major challenge for immune checkpoint inhibitors (ICIs). Interleukin 12 (IL‐12) can invigorate ICIs against cold tumors by establishing a robust antitumor immunity. However, its toxicity and sy
Externí odkaz:
https://doaj.org/article/1923dbcd7fa84cce9709053810b8c054
Autor:
George Lo Huang, Anqi Tao, Takuya Miyazaki, Thahomina Khan, Taehun Hong, Yasuhiro Nakagawa, Horacio Cabral
Publikováno v:
Nanomaterials, Vol 9, Iss 5, p 719 (2019)
Indoleamine 2,3-dioxygenase (IDO) is an immunomodulating enzyme that is overexpressed in many cancers with poor prognosis. IDO suppresses T cell immunity by catabolizing tryptophan into kynurenine (KYN), which induces apoptosis in T effector cells an
Externí odkaz:
https://doaj.org/article/6fcf7de7e9fb44d8ac6d146f97cd545d