Zobrazeno 1 - 10
of 84
pro vyhledávání: '"George Liapakis"'
Autor:
Christos Markatos, Georgia Biniari, Oleg G. Chepurny, Vlasios Karageorgos, Nikos Tsakalakis, Georgios Komontachakis, Zacharenia Vlata, Maria Venihaki, George G. Holz, Theodore Tselios, George Liapakis
Publikováno v:
Molecules, Vol 29, Iss 17, p 4127 (2024)
The gonadotropin-releasing hormone (GnRH) receptor (GnRH-R) is highly expressed in ovarian cancer cells (OCC), and it is an important molecular target for cancer therapeutics. To develop a new class of drugs targeting OCC, we designed and synthesized
Externí odkaz:
https://doaj.org/article/629b6733c8b64a05a82d4be18e501779
Autor:
Md Rabiul Islam, Christos Markatos, Ioannis Pirmettis, Minas Papadopoulos, Vlasios Karageorgos, George Liapakis, Hesham Fahmy
Publikováno v:
Molecules, Vol 29, Iss 15, p 3647 (2024)
Corticotropin-releasing factor (CRF) is a key neuropeptide hormone that is secreted from the hypothalamus. It is the master hormone of the HPA axis, which orchestrates the physiological and behavioral responses to stress. Many disorders, including an
Externí odkaz:
https://doaj.org/article/4fb064557aee492bb738d44bef8d8f07
Autor:
Minos-Timotheos Matsoukas, Vasilis Panagiotopoulos, Vlasios Karageorgos, George P. Chrousos, Maria Venihaki, George Liapakis
Publikováno v:
Biology, Vol 13, Iss 2, p 120 (2024)
Corticotropin-releasing factor or hormone (CRF or CRH) and the urocortins regulate a plethora of physiological functions and are involved in many pathophysiological processes. CRF and urocortins belong to the family of CRF peptides (CRF family), whic
Externí odkaz:
https://doaj.org/article/e7e7f49d95d74b68a5db4cd43603bfcf
Autor:
Tahsin F. Kellici, Dimitrios Ntountaniotis, George Liapakis, Andreas G. Tzakos, Thomas Mavromoustakos
Publikováno v:
Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 5062-5078 (2019)
In this article, the conformational properties of olmesartan and its methylated analogue were charted using a combination of NMR spectroscopy and molecular modeling. For the molecular docking experiments three different forms of angiotensin II type 1
Externí odkaz:
https://doaj.org/article/fb1cd449792a4ed492dc5e945ad57a76
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1185 (2021)
Dehydroepiandrosterone (DHEA), an adrenal and neurosteroid hormone with strong neuroprotective and immunomodulatory properties, and ligand for all high-affinity neurotrophin tyrosine kinase receptors (Trk), also exerts important effects on hyperalges
Externí odkaz:
https://doaj.org/article/bd0bffbc90284f02b562e666d3c7d1fe
Autor:
Eirini Dermitzaki, George Liapakis, Ariadne Androulidaki, Maria Venihaki, John Melissas, Christos Tsatsanis, Andrew N Margioris
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97060 (2014)
Chronic activation of innate immunity takes place in obesity and initiated by the hypertrophic adipocytes which obtain a pro-inflammatory phenotype. The corticotrophin-releasing factor (CRF) family of neuropeptides and their receptors (CRF1 and CRF2)
Externí odkaz:
https://doaj.org/article/8851cf02b9ff49209131b5071f5507d0
Autor:
Olga Rassouli, George Liapakis, Iakovos Lazaridis, George Sakellaris, Kostas Gkountelias, Achille Gravanis, Andrew N Margioris, Katia P Karalis, Maria Venihaki
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21654 (2011)
Corticotropin-releasing hormone, or factor, (CRH or CRF) exerts important biological effects in multiple peripheral tissues via paracrine/autocrine actions. The aim of our study was to assess the effects of endogenous CRH in the biology of mouse and
Externí odkaz:
https://doaj.org/article/53402426ecbb4775acaf0a132afeaf1f
Publikováno v:
Biomedicines
Volume 9
Issue 9
Biomedicines, Vol 9, Iss 1185, p 1185 (2021)
Volume 9
Issue 9
Biomedicines, Vol 9, Iss 1185, p 1185 (2021)
Dehydroepiandrosterone (DHEA), an adrenal and neurosteroid hormone with strong neuroprotective and immunomodulatory properties, and ligand for all high-affinity neurotrophin tyrosine kinase receptors (Trk), also exerts important effects on hyperalges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3291e354549f91c6dcd088d14a8aa3d7
http://europepmc.org/articles/PMC8469064
http://europepmc.org/articles/PMC8469064
Autor:
Amgad Albohy, Sherif F. Hammad, George Liapakis, Khaled A.M. Abouzid, Ioannis Pirmettis, Oleg G. Chepurny, Vlasios Karageorgos, Nageh Aboutaleb, Sotirios Kakabakos, George G. Holz, Hossam R. Elgiushy
Publikováno v:
Bioorg Chem
Corticotrophin releasing factor receptor-1 (CRFR1) is a potential target for treatment of depression and anxiety through modifying stress response. A series of new thiazolo[4,5-d]pyrimidine derivatives were designed, prepared and biologically evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8134304567ec425ed0a103b3c7ebb241
https://europepmc.org/articles/PMC8387444/
https://europepmc.org/articles/PMC8387444/
Autor:
Minos-Timotheos Matsoukas, Vassiliki Magafa, Andrew N. Margioris, Andreas G. Tzakos, George Liapakis, Vlasios Karageorgos, George Varvounis, Michail Pardalos, Georgios A. Spyroulias, Revekka Exarchakou, Evgenios Κ. Stylos, Eirini Dermitzaki
Publikováno v:
Amino Acids. 51:1009-1022
Neurotensin (NT) (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) exerts a dual function as a neurotransmitter/neuromodulator in the central nervous system and as a hormone/cellular mediator in periphery. This dual function of NT establishes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88146257bf34f6281c791f7f9af233a
https://doi.org/10.1007/s00726-019-02741-2
https://doi.org/10.1007/s00726-019-02741-2