Zobrazeno 1 - 3
of 3
pro vyhledávání: '"George Leslie Seibel"'
Autor:
Lisa Marshall, Ruth J. Mayer, Mark McCord, Ravi Shanker Garigipati, Brian Bolognese, George Leslie Seibel, Jerry L. Adams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1421-1426
Design and synthesis of some TSA inhibitors on novel molecular frameworks is described. This TSA analog design culminates in the preparation of the phosphonate 18.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2fe7740193ee22480f1fb4cb884efb5
https://doi.org/10.1016/s0960-894x(97)00246-1
https://doi.org/10.1016/s0960-894x(97)00246-1
Autor:
Timothy Francis Gallagher, Seth M. Fisher, Peter C. McDonnell, George P. Livi, George Leslie Seibel, Megan M. McLaughlin, Steven A. Carr, John C. Lee, Shouki Kassis, Sanjay Kumar, Jerry L. Adams, Terence G. Porter, Dean E. McNulty, Peter R. Young, Michael L. Doyle, Michael J. Huddleston
Publikováno v:
Journal of Biological Chemistry. 272:12116-12121
The site of action of a series of pyridinyl imidazole compounds that are selective inhibitors of p38 mitogen-activated protein kinase in vitro and block proinflammatory cytokine production in vivo has been determined. Using Edman sequencing, 125I-SB2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d640422c25ef6c1dfe2422f9bfa5bf6
https://doi.org/10.1074/jbc.272.18.12116
https://doi.org/10.1074/jbc.272.18.12116
Autor:
Jeffrey T. Laydon, Glenn A. Hofmann, Jeffrey C. Boehm, Jeffrey W. Abt, Margaret E. Soreson, Susan M. Fier-Thompson, Juanita M. Smietana, Peter R. Young, Timothy Francis Gallagher, John C. Lee, Mary Jane Blumenthal, Arnold J. Krog, Ralph Hall, Dennis Lee, Paul Elliot Bender, Karl F. Erhard, Ravi Shanker Garigipati, Jerry L. Adams, Peter C. McDonnell, George Leslie Seibel, Shouki Kassis, Sanjay Kumar, Peter L. Sheldrake
Publikováno v:
Bioorganicmedicinal chemistry. 5(1)
Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR and protein homology modeling, the pharmacophore and three potential m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e122df6ffe903523b617fc84550c0c
https://pubmed.ncbi.nlm.nih.gov/9043657
https://pubmed.ncbi.nlm.nih.gov/9043657