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Akademický článek

An IL‐12‐Based Nanocytokine Safely Potentiates Anticancer Immunity through Spatiotemporal Control of Inflammation to Eradicate Advanced Cold Tumors

Autor: Pengwen Chen, Wenqian Yang, Koji Nagaoka, George Lo Huang, Takuya Miyazaki, Taehun Hong, Shangwei Li, Kazunori Igarashi, Kazuyoshi Takeda, Kazuhiro Kakimi, Kazunori Kataoka, Horacio Cabral

Publikováno v: Advanced Science, Vol 10, Iss 10, Pp n/a-n/a (2023)

Abstract Treatment of immunologically cold tumors is a major challenge for immune checkpoint inhibitors (ICIs). Interleukin 12 (IL‐12) can invigorate ICIs against cold tumors by establishing a robust antitumor immunity. However, its toxicity and sy

Externí odkaz: https://doaj.org/article/1923dbcd7fa84cce9709053810b8c054

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Akademický článek

PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase

Autor: George Lo Huang, Anqi Tao, Takuya Miyazaki, Thahomina Khan, Taehun Hong, Yasuhiro Nakagawa, Horacio Cabral

Publikováno v: Nanomaterials, Vol 9, Iss 5, p 719 (2019)

Indoleamine 2,3-dioxygenase (IDO) is an immunomodulating enzyme that is overexpressed in many cancers with poor prognosis. IDO suppresses T cell immunity by catabolizing tryptophan into kynurenine (KYN), which induces apoptosis in T effector cells an

Externí odkaz: https://doaj.org/article/6fcf7de7e9fb44d8ac6d146f97cd545d

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Akademický článek

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Akademický článek

Characterization, optimization and emission analysis of manually-made charcoal dust briquettes with starch, paper and algae binders

Autor: George Lomunyak, Booker Osodo, Francis Njoka, Emmanuel Kombe

Publikováno v: Heliyon, Vol 10, Iss 24, Pp e40991- (2024)

Utilization of loose waste biomass such as charcoal dust remains popular in low-to mid-income countries due to increased energy demands, poverty and heighten efforts to mitigate climate change. This study sought to investigate the effects of starch,

Externí odkaz: https://doaj.org/article/383ea97a367344b5b0751de232b0838b

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Akademický článek

The amphibians and reptiles of Cusuco National Park, Northwest Honduras: updates from a long-term conservation programme

Autor: Alexandra E. Laking, José M. Solís, Tom Brown, Simon T. Maddock, Oliver Burdekin, Peter Taylor, George Lonsdale, Stephen E. W. Green, Thomas E. Martin, Josue R. Galdamez, Jonathan E. Kolby, Jesse Erens, Merlijn Jocque

Publikováno v: Neotropical Biology and Conservation, Vol 19, Iss 2, Pp 37-62 (2024)

Mesoamerican cloud forests support a rich and unique biodiversity but face severe threats from increasing habitat degradation and climate change. Here, we present an updated overview of the amphibians and reptiles of Cusuco National Park (CNP), an is

Externí odkaz: https://doaj.org/article/b1656d5f72b0428fadc8cc90a9088dc3

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Akademický článek

Qualitative exploration of patients’ experiences with Intrabeam TARGeted Intraoperative radioTherapy (TARGIT-IORT) and External-Beam RadioTherapy Treatment (EBRT) for breast cancer

Autor: Jayant S Vaidya, Siobhan Laws, Jennifer Royle, Sandeep Kumar Bagga, Natalie Swiderska, Charlotte Hooker, Marie Ennis-O'Connor, Siobhan Freeney, Dympna Watson, Robin Woolcock, George Lodge

Publikováno v: BMJ Open, Vol 14, Iss 8 (2024)

Objective To gather a deep qualitative understanding of the perceived benefits and impacts of External-Beam RadioTherapy (EBRT) and TARGeted Intraoperative radioTherapy (TARGIT-IORT) using Intrabeam to assess how the treatments affected patient/care

Externí odkaz: https://doaj.org/article/50b27ab332144b07839345a75054159c

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Akademický článek

AndroDex: Android Dex Images of Obfuscated Malware

Autor: Sana Aurangzeb, Muhammad Aleem, Muhammad Taimoor Khan, George Loukas, Georgia Sakellari

Publikováno v: Scientific Data, Vol 11, Iss 1, Pp 1-10 (2024)

Abstract With the emergence of technology and the usage of a large number of smart devices, cyber threats are increasing. Therefore, research studies have shifted their attention to detecting Android malware in recent years. As a result, a reliable a

Externí odkaz: https://doaj.org/article/abc784bc8d5d4c4788559ac970e04d1c

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Akademický článek

UReum: A Universally Composable Blockchain-Enabled Model for Secure and Privacy-Preserving Data Awareness in Energy Internet

Autor: Abubakar Sadiq Sani, Dong Yuan, George Loukas, Zhao Yang Dong

Publikováno v: IEEE Access, Vol 12, Pp 171396-171417 (2024)

Recent findings show that many energy nodes rely on energy operators for inputs on energy operations. In this paper, we introduce UReum, a universally composable blockchain-enabled secure and privacy-preserving data awareness solution by which energy

Externí odkaz: https://doaj.org/article/4981bf98d1844d25a725b546d8bca708

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Akademický článek

Three Pilot Randomized Controlled Trials Evaluating a Persuasive Health Communication Intervention for Adult Emergency Department Patients Declining HIV/HCV Testing

Autor: Roland C. Merchant, Melissa A. Clark, Michael P. Carey, Tao Liu, George Loo, Ethan A. Cowan

Publikováno v: Journal of Scientific Innovation in Medicine, Vol 7, Iss 1, Pp 3-3 (2024)

Background: The lack of evidence-based interventions to overcome patient refusal limits the success of emergency department (ED)-based HIV and hepatitis C virus (HCV) testing for diagnostic purposes or screening. We created a persuasive health commun

Externí odkaz: https://doaj.org/article/9b82969695d643c8af38f9cf84e12168

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