Zobrazeno 1 - 10
of 37
pro vyhledávání: '"George L. Mulvey"'
Autor:
Glen D. Armstrong, George L. Mulvey, Thomas P. Griener, Ravin Narain, Zhicheng Deng, Marya Ahmed, Joanna M. Sadowska, Eugenia Paszkiewicz, Pavel I. Kitov, David R. Bundle
Publikováno v:
Toxins, Vol 3, Iss 9, Pp 1065-1088 (2011)
Inhibition of AB5-type bacterial toxins can be achieved by heterobifunctional ligands (BAITs) that mediate assembly of supramolecular complexes involving the toxin’s pentameric cell membrane-binding subunit and an endogenous protein, serum amyloid
Externí odkaz:
https://doaj.org/article/94a8a4f28d5f47108e25639e91613b18
Autor:
Thomas P Griener, Jonathan G Strecker, Romney M Humphries, George L Mulvey, Carmen Fuentealba, Robert E W Hancock, Glen D Armstrong
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21457 (2011)
Transgenic C57BL/6 mice expressing human serum amyloid P component (HuSAP) are resistant to Shiga toxin 2 (Stx2) at dosages that are lethal in HuSAP-negative wild-type mice. However, it is well established that Stx2 initiates extra-intestinal complic
Externí odkaz:
https://doaj.org/article/574a14306d43403eac36037931ff57d4
Publikováno v:
Toxins, Vol 7, Iss 10, Pp 4054-4066 (2015)
Toxins
Volume 7
Issue 10
Pages 4054-4066
Toxins
Volume 7
Issue 10
Pages 4054-4066
Infection by Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli (EHEC) results in severe diarrhea, hemorrhagic colitis, and, occasionally, hemolytic-uremic syndrome (HUS). HUS is associated with an increase in pro-inflammatory cytokines a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d7f3c73c195b5a98db84e6d74d8107b
http://www.mdpi.com/2072-6651/7/10/4054
http://www.mdpi.com/2072-6651/7/10/4054
Publikováno v:
Infection and Immunity. 79:4061-4067
Although toxins A and B are known to be important contributors to the acute phase of Clostridium difficile infection, the role of colonization and adherence to host tissues in the overall pathogenesis of these organisms remains unclear. Consequently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aecc2b62c62d22d5a4e667b320b5526
https://doi.org/10.1128/iai.05305-11
https://doi.org/10.1128/iai.05305-11
Autor:
George L. Mulvey, Glen D. Armstrong, Pavel I. Kitov, Ravin Narain, Zhicheng Deng, Eugenia Paszkiewicz, Marya Ahmed, Joanna M. Sadowska, Thomas P. Griener, David R. Bundle
Publikováno v:
Toxins, Vol 3, Iss 9, Pp 1065-1088 (2011)
Toxins
Volume 3
Issue 9
Pages 1065-1088
Toxins
Volume 3
Issue 9
Pages 1065-1088
Inhibition of AB(5)-type bacterial toxins can be achieved by heterobifunctional ligands (BAITs) that mediate assembly of supramolecular complexes involving the toxin's pentameric cell membrane-binding subunit and an endogenous protein, serum amyloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a0d8d451655856ef0d180b407f6362
http://www.mdpi.com/2072-6651/3/9/1065/
http://www.mdpi.com/2072-6651/3/9/1065/
Publikováno v:
Journal of Medical Microbiology. 60:1181-1187
Herein we present evidence for the therapeutic potential of colonization factor (CF)-specific egg yolk antibodies (IgY) for potentially treating acute and recurring Clostridium difficile infection (CDI) in humans. The study involved cloning, expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db49b8af8e0a25e083602636bc8cc8fe
https://doi.org/10.1099/jmm.0.029835-0
https://doi.org/10.1099/jmm.0.029835-0
Publikováno v:
Journal of Medical Microbiology. 59:920-924
Herein we describe a real-time quantitative PCR assay for evaluating the adherence of Clostridium difficile to differentiated human intestinal Caco-2 cells. Our investigations demonstrated that the method, employing the C. difficile-specific triose-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3bc451474c3ec8ac25d538bf77ede3
https://doi.org/10.1099/jmm.0.019752-0
https://doi.org/10.1099/jmm.0.019752-0
Autor:
George L. Mulvey, Thomas P. Griener, Pavel I. Kitov, Romney M. Humphries, Tracy L. Raivio, Michael S. Donnenberg, Stefanie L. Vogt, Glen D. Armstrong, Michael G. Surette
Publikováno v:
Molecular Microbiology. 76:1111-1126
Enteropathogenic Escherichia coli (EPEC) are a major cause of infant morbidity and mortality due to diarrhoea in developing countries. The pathogenesis of EPEC is dependent on a coordinated multi-step process culminating in the intimate adherence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab90d537a14a1ad1a2d33b7245af6591
https://doi.org/10.1111/j.1365-2958.2010.07192.x
https://doi.org/10.1111/j.1365-2958.2010.07192.x
Assembly and Stability of the Shiga Toxins Investigated by Electrospray Ionization Mass Spectrometry
Autor:
Glen D. Armstrong, John S. Klassen, Thomas P. Griener, George L. Mulvey, Igor Sinelnikov, Elena N. Kitova, Tanis C. Dingle, Stefanie Wee
Publikováno v:
Biochemistry. 48:5365-5374
A systematic investigation into the assembly and stability of native and modified subunits of the Shiga toxins (Stx) in vitro is described. Analysis of the assembly of native and modified B subunits of Stx1 and Stx2 in solution, carried out using ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bef992cdc23e3b40b59d19bd32154b9
https://doi.org/10.1021/bi9003155
https://doi.org/10.1021/bi9003155
Autor:
Elena N. Kitova, George L. Mulvey, Glen D. Armstrong, Kenneth K.-S. Ng, Shuangjun Lin, Antonio Greco, Jiangxiao Sun, Tanis C. Dingle, Monica M. Palcic, John S. Klassen, Stefanie Wee
Publikováno v:
Glycobiology. 18:698-706
The biological and ligand-binding properties of recombinant C-terminal cell-binding domains (CBDs) and subdomains of the two large exotoxins, Toxin A (TcdA) and Toxin B (TcdB) expressed by Clostridium difficile were examined in the hemagglutination a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bae2947de5ae9faf28937a2149b6e31
https://doi.org/10.1093/glycob/cwn048
https://doi.org/10.1093/glycob/cwn048