Výsledky vyhledávání - "George L. Coffman"

Purification and characterization of a recombinant Yersinia pestis V-F1 'Reversed' fusion protein for use as a new subunit vaccine against plague

Autor: George L. Coffman, Bradford S. Powell, Ronald W. Raab, Jeremy Goodin, Robert L. McKown, Jeffrey T. Enama, Gerard P. Andrews

Publikováno v: Protein Expression and Purification. 76:136-144

We previously developed a unique recombinant protein vaccine against plague composed of a fusion between the Fraction 1 capsular antigen (F1) and the V antigen. To determine if overall expression, solubility, and recovery of the F1-V fusion protein c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064b46792bd724451f88bf2f2513d797
https://doi.org/10.1016/j.pep.2010.10.011

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Yersinia pestis outer membrane type III secretion protein YscC: expression, purification, characterization, and induction of specific antiserum

Autor: Jeffrey T. Enama, Ronald W. Raab, Robert L. McKown, John A. Ligon, Jeremy Goodin, Gerard P. Andrews, George L. Coffman, Bradford S. Powell

Publikováno v: Protein Expression and Purification. 40:152-163

The type III secretion system (YscC) protein of Yersinia pestis plays an essential role in the translocation of Yersinia outer proteins (Yops) into eukaryotic target cells through a type III secretion mechanism. To assess the immunogenicity and poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a503ef9a35aa948cbe6be0d29344e4f1
https://doi.org/10.1016/j.pep.2004.11.001

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Thermopile Sensors for the Detection of Airborne Pollutants

Autor: P.T. Olin, George L. Coffman, T. C. Devore, David J. Lawrence, W.G. Tucker

Publikováno v: 2007 IEEE Sensors.

We have developed sensors for airborne pollutants using 36-junction thermopiles as the sensing platform. The thermopiles detect heat released when airborne pollutants react with chemical coatings applied to the sensing junctions. Our thermopiles cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7257ec1e60bcd01b3b952479c23c54c7
https://doi.org/10.1109/icsens.2007.4388633

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Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways

Autor: Jinling Xie, Jiahu Wang, Ronald W. Raab, Robert L. McKown, Ningning Wang, George L. Coffman, Shannon L. Beck, Isa M. Hussaini, Gordon W. Laurie, Peisong Ma, Staci C. Walton

Publikováno v: The Journal of Cell Biology

Renewal of nongermative epithelia is poorly understood. The novel mitogen "lacritin" is apically secreted by several nongermative epithelia. We tested 17 different cell types and discovered that lacritin is preferentially mitogenic or prosecretory fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41b95019785bbb525726908f35a30f5
https://pubmed.ncbi.nlm.nih.gov/16923831

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Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin

Autor: Atsushi Utani, Shannon L. Beck, Peisong Ma, Robert L. McKown, Gordon W. Laurie, Alan C. Rapraeger, Ronald W. Raab, William J. Chirico, George L. Coffman

Publikováno v: The Journal of Cell Biology

Cell surface heparan sulfate (HS) proteoglycans are carbohydrate-rich regulators of cell migratory, mitogenic, secretory, and inflammatory activity that bind and present soluble heparin-binding growth factors (e.g., fibroblast growth factor, Wnt, Hh,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696bdf397de8d669790db10603a4b0a7
https://doi.org/10.1083/jcb.20051113420110107c

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Identification of Syndecan-1 as a Coreceptor for Prosecretory Mitogen ‘Lacritin’

Autor: Peisong Ma, George L. Coffman, Robert L. McKown, R. W. Raab, Gordon W. Laurie, Shannon L. Beck

Publikováno v: The Ocular Surface. 3:S87

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::198107c08c3ed1819388d36113addaba
https://doi.org/10.1016/s1542-0124(12)70481-0

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Deletion analysis of Novel Lacrimal Prosecretory Mitogen ‘Lacritin’ suggests involvement of its C-Terminal Amphipathic Alpha Helix in Calcium Signaling and Mitogenesis

Autor: George L. Coffman, Robert L. McKown, R. W. Raab, Staci C. Walton, Jiahu Wang, Gordon W. Laurie

Publikováno v: The Ocular Surface. 3:S125

THE OCULAR SURFACE / JANUARY, 2005, VOL. 3, NO. 1 / SUPPLEMENT S125 DELETION ANALYSIS OF NOVEL LACRIMAL PROSECRETORY MITOGEN ‘LACRITIN’ SUGGESTS INVOLVEMENT OF ITS CTERMINAL AMPHIPATHIC ALPHA HELIX IN CALCIUM SIGNALING AND MITOGENESIS. Jiahu Wang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e26cbbf7a71d11fb3c5ffddd9979fb25
https://doi.org/10.1016/s1542-0124(12)70589-x

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Monoazido analog of ethidium as a chromatin probe: binding to DNA

Autor: L. W. Yielding, George L. Coffman, K. Lemone Yielding

Publikováno v: Biopolymers. 23(6)

Two photoaffinity analogs of ethidium, 8-azido-3-amino, and 3-azido-8-amino-5-ethyl-6-phenylphenanthridinium chloride, have been used to probe the structure of mammalian chromatin and its interactions with the ethidium moiety. The monoazido analogs w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d7724fa7e9d1b8f7078e676f0ab260
https://pubmed.ncbi.nlm.nih.gov/6733248

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