Zobrazeno 1 - 10
of 89
pro vyhledávání: '"George Kukolj"'
Autor:
Kristi L Berger, Christoph Sarrazin, David R Nelson, Joseph Scherer, Nanshi Sha, Martin Marquis, Alexandra Côté-Martin, Richard Vinisko, Jerry O Stern, Federico J Mensa, George Kukolj
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160668 (2016)
BACKGROUND & AIM:The resistance profile of anti-hepatitis C virus (HCV) agents used in combination is important to guide optimal treatment regimens. We evaluated baseline and treatment-emergent NS3/4A and NS5B amino-acid variants among HCV genotype (
Externí odkaz:
https://doaj.org/article/3c2529bb06804ff7a9a625d74fa704f7
Autor:
Craig S. Pace, Kim J. Hasenkrug, Ulf Dittmer, Sekar Natesampillai, Kathrin Sutter, Marek Widera, Dakota L. Pouncey, Brent Race, Kerry J. Lavender, Katie Phillips, Nathan W. Cummins, Joshua Goldsmith, George Kukolj, Ronald J. Messer, Jim Zheng, Erik Van Dis
Publikováno v:
AIDS. 32:1-10
Although bone marrow, liver, thymus (BLT)-humanized mice provide a robust model for HIV-1 infection and enable evaluation of cure strategies dependent on endogenous immune responses, most mice develop graft versus host disease (GVHD), limiting their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597b3ce21137dafb0dc0c139222231b6
https://doi.org/10.1097/qad.0000000000001674
https://doi.org/10.1097/qad.0000000000001674
Autor:
Rebecca Hoh, Jeffrey P. Murry, Alivelu Irrinki, Tomas Cihlar, Garry P. Nolan, Li Li, Stefan Pflanz, Christopher W. Pohlmeyer, Aaron Arvey, Veronica D. Gonzalez, Steven G. Deeks, Gundula Min-Oo, Andrew Mulato, George Kukolj, Ricardo Ramirez
Publikováno v:
Journal of virology, vol 93, iss 7
HIV infection is controlled immunologically in a small subset of infected individuals without antiretroviral therapy (ART), though the mechanism of control is unclear. CD8(+) T cells are a critical component of HIV control in many immunological contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270c88da9ea299c484345c618dffe283
https://doi.org/10.1128/jvi.01790-18
https://doi.org/10.1128/jvi.01790-18
Autor:
Jeffrey P. Murry, Alivelu Irrinki, Tomas Cihlar, Jasmine Kaur, Derek D. Sloan, Angela Tsai, George Kukolj
Publikováno v:
Journal of Virology
Antiretroviral therapy can suppress HIV replication to undetectable levels but does not eliminate latent HIV, thus necessitating lifelong therapy. Recent efforts to target this persistent reservoir have focused on inducing the expression of latent HI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0891021e036a27f4dcd8ad2ce5519bdb
http://europepmc.org/articles/PMC5375698
http://europepmc.org/articles/PMC5375698
Autor:
Christian Brochu, James Gillard, Michael Bös, Martin Marquis, Richard Bethell, Gulrez Fazal, George Kukolj, Michel Garneau, Timothy A. Stammers, Paul C. Anderson, Dominik Wernic, Pierre L. Beaulieu, Stephen H. Kawai, Ginette McKercher, Marc-André Poupart, Jianmin Duan, Bounkham Thavonekham, Yves Bousquet, Michael G. Cordingley
Publikováno v:
Journal of Medicinal Chemistry. 57:10130-10143
The development of interferon-free regimens for the treatment of chronic HCV infection constitutes a preferred option that is expected in the future to provide patients with improved efficacy, better tolerability, and reduced risk for emergence of dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c2526b2206e311f04252cc1bdbf310
https://doi.org/10.1021/jm501532z
https://doi.org/10.1021/jm501532z
Autor:
Craig J. Morton, Barbara Frey, George Kukolj, Alistair George Draffan, Van T. T. Nguyen, Angela Luttick, Tyrone Pieter Jeynes, Ginette McKercher, Bruno Simoneau, Richard Hufton, Kate Porter, Danielle Tilmanis, Bo Lin, Simon P. Tucker, Jesse D. Thomas, Melinda J. Pryor, Jianmin Duan, Lilly Michael John, Paula Francom, Edward M. Tyndall, Silas Bond, Lisette Lagacé, Carlie T. Gannon, Ma’an Amad, Veronika Wirth, Rosliana Halim, Richard Bethell, Saba Jahangiri, Brett Pool
Publikováno v:
ACS Medicinal Chemistry Letters. 5:679-684
Nucleoside analogues have long been recognized as prospects for the discovery of direct acting antivirals (DAAs) to treat hepatitis C virus because they have generally exhibited cross-genotype activity and a high barrier to resistance. C-Nucleosides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2b73cd6b0e37544386aa833a0c233c
https://doi.org/10.1021/ml500077j
https://doi.org/10.1021/ml500077j
Autor:
Mireille Cartier, Gerhard G. Steinmann, George Kukolj, Jerry O. Stern, Kristi L. Berger, Joseph Scherer, Wulf O. Böcher, Marie-Josée Massariol, Yakov Datsenko, Ibtissem Triki, Martin Marquis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:698-705
A challenge to the treatment of chronic hepatitis C with direct-acting antivirals is the emergence of drug-resistant hepatitis C virus (HCV) variants. HCV with preexisting polymorphisms that are associated with resistance to NS3/4A protease inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3cf07fb110ae329652da0f0c543634
https://doi.org/10.1128/aac.01976-13
https://doi.org/10.1128/aac.01976-13
Autor:
Jeong Heo, Jacob Lalezari, Stefan Mauss, Mark S. Sulkowski, Yakov Datsenko, Fernando Bessone, Barbara A. Leggett, Hugo Fainboim, Peter Ferenci, Tarik Asselah, Gerhard Nehmiz, Gerhard G. Steinmann, George Kukolj, Jerry O. Stern, Joseph Scherer, Wulf O. Böcher
Publikováno v:
Hepatology. 57:2143-2154
Faldaprevir (BI 201335) is a potent, hepatitis C virus (HCV) NS3/4A protease inhibitor with pharmacokinetic properties supportive of once-daily (QD) dosing. Four hundred and twenty-nine HCV genotype (GT)-1 treatment-naive patients without cirrhosis w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d991de92f4cab01b4f00f3d1a7be8fd
https://doi.org/10.1002/hep.26276
https://doi.org/10.1002/hep.26276
Autor:
Lisette Lagacé, George Kukolj, Benoît Moreau, Peter W. White, Cédrickx Godbout, Montse Llinas-Brunet, Diane Thibeault, Christopher T. Lemke, Jeff A. O'Meara
Publikováno v:
Journal of Biological Chemistry. 288:5673-5681
Although optimizing the resistance profile of an inhibitor can be challenging, it is potentially important for improving the long term effectiveness of antiviral therapy. This work describes our rational approach toward the identification of a macroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9735e2e222df55ac56d610ab67ed6c8c
https://doi.org/10.1074/jbc.m112.439455
https://doi.org/10.1074/jbc.m112.439455
Autor:
Martin Marquis, Christoph Sarrazin, Federico J. Mensa, Alexandra Côté-Martin, Richard Vinisko, David R. Nelson, George Kukolj, Jerry O. Stern, Kristi L. Berger, Joseph Scherer, Nanshi Sha
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160668 (2016)
PLoS ONE
PLoS ONE
Background & Aim: The resistance profile of anti-hepatitis C virus (HCV) agents used in combination is important to guide optimal treatment regimens. We evaluated baseline and treatment-emergent NS3/4A and NS5B amino-acid variants among HCV genotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af5b9ac93afd81e36bfc74cf0d553fa
http://europepmc.org/articles/PMC4975400?pdf=render
http://europepmc.org/articles/PMC4975400?pdf=render