Zobrazeno 1 - 10
of 134
pro vyhledávání: '"George Kemble"'
Autor:
Ali Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Lara Rizotto, Mélanie Planque, Ginevra Doglioni, Sahar Motamedi, David Nittner, Tania Roskams, Patrizia Agostinis, Oliver Bechter, Veerle Boecxstaens, Marjan Garmyn, Marie O’Farrell, Alan Wagman, George Kemble, Eleonora Leucci, Sarah-Maria Fendt, Jean-Christophe Marine, Johannes V. Swinnen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)
Abstract Background One of the key limitations of targeted cancer therapies is the rapid onset of therapy resistance. Taking BRAF-mutant melanoma as paradigm, we previously identified the lipogenic regulator SREBP-1 as a central mediator of resistanc
Externí odkaz:
https://doaj.org/article/8829970c22234a53b950a2b7f4311f51
Autor:
Marie O’Farrell, Greg Duke, Richard Crowley, Douglas Buckley, Eduardo B. Martins, Dipankar Bhattacharya, Scott L. Friedman, George Kemble
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Fatty acid synthase (FASN) is an attractive therapeutic target in non-alcoholic steatohepatitis (NASH) because it drives de novo lipogenesis and mediates pro-inflammatory and fibrogenic signaling. We therefore tested pharmacological inhibiti
Externí odkaz:
https://doaj.org/article/b33eeb880fcb45fca9716afc443aa3b3
Autor:
Caterina Bartolacci, Cristina Andreani, Gonçalo Vale, Stefano Berto, Margherita Melegari, Anna Colleen Crouch, Dodge L. Baluya, George Kemble, Kurt Hodges, Jacqueline Starrett, Katerina Politi, Sandra L. Starnes, Daniele Lorenzini, Maria Gabriela Raso, Luisa M. Solis Soto, Carmen Behrens, Humam Kadara, Boning Gao, Ignacio I. Wistuba, John D. Minna, Jeffrey G. McDonald, Pier Paolo Scaglioni
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Mutant KRAS (KM) is associated with poor prognosis in lung cancer and reported to promote lipid metabolism. Here, the authors show that fatty acid synthesis, which provides lipids to repair oxidized phospholipids through the FASN-Lands cycle axis, is
Externí odkaz:
https://doaj.org/article/cecb398260bb4e0d93d08e97a822d9aa
Autor:
Barbara Schroeder, Travis Vander Steen, Ingrid Espinoza, Chandra M. Kurapaty Venkatapoorna, Zeng Hu, Fernando Martín Silva, Kevin Regan, Elisabet Cuyàs, X. Wei Meng, Sara Verdura, Aina Arbusà, Paula A. Schneider, Karen S. Flatten, George Kemble, Joan Montero, Scott H. Kaufmann, Javier A. Menendez, Ruth Lupu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Abstract Inhibitors of the lipogenic enzyme fatty acid synthase (FASN) have attracted much attention in the last decade as potential targeted cancer therapies. However, little is known about the molecular determinants of cancer cell sensitivity to FA
Externí odkaz:
https://doaj.org/article/aa72c25e3f5c4af1a2822139760db5bf
Autor:
Caterina Bartolacci, Cristina Andreani, Gonçalo Vale, Stefano Berto, Margherita Melegari, Anna Colleen Crouch, Dodge L. Baluya, George Kemble, Kurt Hodges, Jacqueline Starrett, Katerina Politi, Sandra L. Starnes, Daniele Lorenzini, Maria Gabriela Raso, Luisa M. Solis Soto, Carmen Behrens, Humam Kadara, Boning Gao, Ignacio I. Wistuba, John D. Minna, Jeffrey G. McDonald, Pier Paolo Scaglioni
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/4f7776977c6a4b6b862479ccb23250e3
Autor:
Gerald Falchook, Jeffrey Infante, Hendrik-Tobias Arkenau, Manish R. Patel, Emma Dean, Erkut Borazanci, Andrew Brenner, Natalie Cook, Juanita Lopez, Shubham Pant, Arthur Frankel, Peter Schmid, Kathleen Moore, William McCulloch, Katharine Grimmer, Marie O'Farrell, George Kemble, Howard Burris
Publikováno v:
EClinicalMedicine, Vol 34, Iss , Pp 100797- (2021)
Background: We conducted a first-in-human dose-escalation study with the oral FASN inhibitor TVB-2640 to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D), as monotherapy and with a taxane. Methods: This completed open-la
Externí odkaz:
https://doaj.org/article/2febb21dda0b44dcb8507b74f4dd5b16
Autor:
Timothy S. Heuer, Richard Ventura, Kasia Mordec, Julie Lai, Marina Fridlib, Douglas Buckley, George Kemble
Publikováno v:
EBioMedicine, Vol 16, Iss C, Pp 51-62 (2017)
Palmitate, the enzymatic product of FASN, and palmitate-derived lipids support cell metabolism, membrane architecture, protein localization, and intracellular signaling. Tubulins are among many proteins that are modified post-translationally by acyla
Externí odkaz:
https://doaj.org/article/6f1c25fe440a4d5bb962bf5f6a378714
Autor:
Richard Ventura, Kasia Mordec, Joanna Waszczuk, Zhaoti Wang, Julie Lai, Marina Fridlib, Douglas Buckley, George Kemble, Timothy S. Heuer
Publikováno v:
EBioMedicine, Vol 2, Iss 8, Pp 808-824 (2015)
Inhibition of de novo palmitate synthesis via fatty acid synthase (FASN) inhibition provides an unproven approach to cancer therapy with a strong biological rationale. FASN expression increases with tumor progression and associates with chemoresistan
Externí odkaz:
https://doaj.org/article/28834e3476c148f1a56469f98d334506
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144648 (2015)
Fatty acid synthase (FASN) catalyzes the de novo synthesis of palmitate, a fatty acid utilized for synthesis of more complex fatty acids, plasma membrane structure, and post-translational palmitoylation of host and viral proteins. We have developed a
Externí odkaz:
https://doaj.org/article/ad665ad1d48d4f15af2c72a44c40ae16
Autor:
Raburn M Mallory, Elissa Malkin, Christopher S Ambrose, Terramika Bellamy, Li Shi, Tingting Yi, Taff Jones, George Kemble, Filip Dubovsky
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13755 (2010)
The safety, tolerability, and immunogenicity of a monovalent intranasal 2009 A/H1N1 live attenuated influenza vaccine (LAIV) were evaluated in children and adults.Two randomized, double-blind, placebo-controlled studies were completed in children (2-
Externí odkaz:
https://doaj.org/article/e256e25f0d854be2ba56ede4a7a43f39