Zobrazeno 1 - 10
of 171
pro vyhledávání: '"George Kassiotis"'
Autor:
Jef D. Boeke, Kathleen H. Burns, Katherine B. Chiappinelli, Marie Classon, John M. Coffin, Daniel D. DeCarvalho, Joseph D. Dukes, Benjamin Greenbaum, George Kassiotis, Sarah K. Knutson, Arnold J. Levine, Avindra Nath, Sophie Papa, Daniel Rios, John Sedivy, David T. Ting
Publikováno v:
Mobile DNA, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract In November 2022 the first Dark Genome Symposium was held in Boston, USA. The meeting was hosted by Rome Therapeutics and Enara Bio, two biotechnology companies working on translating our growing understanding of this vast genetic landscape
Externí odkaz:
https://doaj.org/article/afb42101dc1c4afbabb0c6b4ea01ef97
Autor:
Hermaleigh Townsley, Joshua Gahir, Timothy W Russell, David Greenwood, Edward J Carr, Matala Dyke, Lorin Adams, Murad Miah, Bobbi Clayton, Callie Smith, Mauro Miranda, Harriet V Mears, Chris Bailey, James R M Black, Ashley S Fowler, Margaret Crawford, Katalin Wilkinson, Matthew Hutchinson, Ruth Harvey, Nicola O'Reilly, Gavin Kelly, Robert Goldstone, Rupert Beale, Padmasayee Papineni, Tumena Corrah, Richard Gilson, Simon Caidan, Jerome Nicod, Steve Gamblin, George Kassiotis, Vincenzo Libri, Bryan Williams, Sonia Gandhi, Adam J Kucharski, Charles Swanton, David L V Bauer, Emma C Wall
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0294897 (2024)
BackgroundSARS-CoV-2 variant Omicron rapidly evolved over 2022, causing three waves of infection due to sub-variants BA.1, BA.2 and BA.4/5. We sought to characterise symptoms and viral loads over the course of COVID-19 infection with these sub-varian
Externí odkaz:
https://doaj.org/article/95e0348e63df41608cfccc1b745cbb54
Autor:
Jan Attig, Judith Pape, Laura Doglio, Anastasiya Kazachenka, Eleonora Ottina, George R. Young, Katey S.S. Enfield, Iker Valle Aramburu, Kevin W. Ng, Nikhil Faulkner, William Bolland, Venizelos Papayannopoulos, Charles Swanton, George Kassiotis
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Increased levels and diversity of human endogenous retrovirus (HERV) transcription characterize most cancer types and are linked with disease outcomes. However, the underlying processes are incompletely understood. Here, we show that elevated transcr
Externí odkaz:
https://doaj.org/article/394a3762490547b7bf44934409acfbbe
Autor:
Tom Hofland, Luca Danelli, Georgina Cornish, Tiziano Donnarumma, Deborah M. Hunt, Luiz P. S. de Carvalho, George Kassiotis
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
CD4+ T cells are typically considered as ‘helper’ or ‘regulatory’ populations that support and orchestrate the responses of other lymphocytes. However, they can also develop potent granzyme (Gzm)-mediated cytotoxic activity and CD4+ cytotoxic
Externí odkaz:
https://doaj.org/article/5ac6f82a4af34bec92313e0da9ee0424
Autor:
Timothy F. Spracklen, Simon C. Mendelsohn, Claire Butters, Heidi Facey-Thomas, Raphaella Stander, Debbie Abrahams, Mzwandile Erasmus, Richard Baguma, Jonathan Day, Christiaan Scott, Liesl J. Zühlke, George Kassiotis, Thomas J. Scriba, Kate Webb
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionMultisystem inflammatory syndrome in children (MIS-C) is a severe acute inflammatory reaction to SARS-CoV-2 infection in children. There is a lack of data describing differential expression of immune genes in MIS-C compared to healthy chi
Externí odkaz:
https://doaj.org/article/d7ac4d8646a54854b4af3a86f551f2e7
Autor:
Anastasiya Kazachenka, George R. Young, Jan Attig, Chrysoula Kordella, Eleftheria Lamprianidou, Emmanuela Zoulia, George Vrachiolias, Menelaos Papoutselis, Elsa Bernard, Elli Papaemmanuil, Ioannis Kotsianidis, George Kassiotis
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-18 (2019)
Abstract Background Myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) are characterised by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse epigenetic repression, s
Externí odkaz:
https://doaj.org/article/bc18ef2bdea645658e48631f6ae61c14
Autor:
Nishkantha Arulkumaran, PhD, Timothy Arthur Chandos Snow, FFICM, Adarsh Kulkarni, MD, David Brealey, PhD, Hannah Rickman, MB BChir, Chloe Rees-Spear, MSc, Moira J. Spyer, PhD, Judith Heaney, PhD, Edmund Garr, PhD, Bryan Williams, PhD, Peter Cherepanov, PhD, George Kassiotis, PhD, Michael Lunn, PhD, Catherine Houlihan, PhD, Laura E. McCoy, PhD, Eleni Nastouli, FRCPath, Mervyn Singer, FRCP
Publikováno v:
Critical Care Explorations, Vol 3, Iss 8, p e0488 (2021)
OBJECTIVES:. Multiple mechanisms have been proposed to explain disease severity in coronavirus disease 2019. Therapeutic approaches need to be underpinned by sound biological rationale. We evaluated whether serum levels of a range of proposed coronav
Externí odkaz:
https://doaj.org/article/46925e63079a4baeb0e11e661970cd1c
Autor:
Nikhil Faulkner, Kevin W Ng, Mary Y Wu, Ruth Harvey, Marios Margaritis, Stavroula Paraskevopoulou, Catherine Houlihan, Saira Hussain, Maria Greco, William Bolland, Scott Warchal, Judith Heaney, Hannah Rickman, Moria Spyer, Daniel Frampton, Matthew Byott, Tulio de Oliveira, Alex Sigal, Svend Kjaer, Charles Swanton, Sonia Gandhi, Rupert Beale, Steve J Gamblin, John W McCauley, Rodney Stuart Daniels, Michael Howell, David Bauer, Eleni Nastouli, George Kassiotis
Publikováno v:
eLife, Vol 10 (2021)
Background: The degree of heterotypic immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains is a major determinant of the spread of emerging variants and the success of vaccination campaigns, but remains incompletel
Externí odkaz:
https://doaj.org/article/53554e64b4f947678adda363fb937cb8
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
The human genome bears evidence of extensive invasion by retroviruses and other retroelements, as well as by diverse RNA and DNA viruses. High frequency of somatic integration of the RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV
Externí odkaz:
https://doaj.org/article/5917b4c215ea421c9cdf6333f4570333
Autor:
Michael D. Buck, Enzo Z. Poirier, Ana Cardoso, Bruno Frederico, Johnathan Canton, Sam Barrell, Rupert Beale, Richard Byrne, Simon Caidan, Margaret Crawford, Laura Cubitt, Sonia Gandhi, Robert Goldstone, Paul R. Grant, Kiran Gulati, Steve Hindmarsh, Michael Howell, Michael Hubank, Rachael Instrell, Ming Jiang, George Kassiotis, Wei-Ting Lu, James I. MacRae, Iana Martini, Davin Miller, David Moore, Eleni Nastouli, Jerome Nicod, Luke Nightingale, Jessica Olsen, Amin Oomatia, Nicola O'Reilly, Anett Rideg, Ok-Ryul Song, Amy Strange, Charles Swanton, Samra Turajlic, Mary Wu, Caetano Reis e Sousa, The Crick COVID-19 Consortium
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
The ongoing pandemic of SARS-CoV-2 calls for rapid and cost-effective methods to accurately identify infected individuals. The vast majority of patient samples is assessed for viral RNA presence by RT-qPCR. Our biomedical research institute, in colla
Externí odkaz:
https://doaj.org/article/5ae84b910d3947409230776bdb593363