Zobrazeno 1 - 10
of 19
pro vyhledávání: '"George K.E. Umanah"'
Autor:
George K.E. Umanah, Mehdi Ghasemi, Xiling Yin, Melissa Chang, Jin Wan Kim, Jianmin Zhang, Erica Ma, Leslie A. Scarffe, Yun-Il Lee, Rong Chen, Kavya Tangella, Amy McNamara, Leire Abalde-Atristain, Mohamad A. Dar, Samuel Bennett, Marisol Cortes, Shaida A. Andrabi, Paschalis-Thomas Doulias, Harry Ischiropoulos, Ted M. Dawson, Valina L. Dawson
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108329- (2020)
Summary: The regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking affects multiple brain functions, such as learning and memory. We have previously shown that Thorase plays an important role in the internal
Externí odkaz:
https://doaj.org/article/56102e16c4a74aa4a73cc1b829f66ae3
Autor:
Ritika Miryala, Olivia Swain, Vinnie Parikh, George K.E. Umanah, Sofia K. Romano, Jocelyn Tsai
Publikováno v:
J Neurosci
Clinical reports suggest that the coronavirus disease-19 (COVID-19) pandemic caused by severe acute respiratory syndrome (SARS)-coronavirus-2 (CoV-2) has not only taken millions of lives, but has also created a major crisis of neurologic complication
Autor:
Liron Mizrahi, Ayat Asleh, Boris Brant, Andrew P. Levy, Reem Jada, George K.E. Umanah, Tchelet Stern, Nina S. Levy, Shani Stern, Idan Rosh, Huda Adwan Shekhidem, Yam Stern, Polina Ofer
Publikováno v:
Molecular psychiatry. 26(12)
Mutations in the IQSEC2 gene are associated with drug-resistant, multifocal infantile and childhood epilepsy; autism; and severe intellectual disability (ID). We used induced pluripotent stem cell (iPSC) technology to obtain hippocampal neurons to in
Autor:
Tae In Kam, Areum Jo, Sungtaek Oh, Yunjong Lee, Sung Ung Kang, Shaida A. Andrabi, Byoung Dae Lee, Ho Chul Kang, Haisong Jiang, Hojin Kang, Lino Tessarollo, Chan Hyun Na, Yun Il Lee, Senthilkumar S. Karuppagounder, Deborah A. Swing, Manoj Kumar, George K.E. Umanah, Xiaobo Mao, Chi Hu Park, Ted M. Dawson, Jin Whan Cho, Hyo Jung Kim, Sangwoo Ham, Han Seok Ko, Hyein Kim, Ji-Yeong Lee, Sheila K. Pirooznia, Joo Ho Shin, Valina L. Dawson, Shih Ching Chou, Hanna Kim, Sun Ha Paek, Stewart Neifert, Hyejin Park, Rin Khang
Publikováno v:
Sci Transl Med
Accumulation of the parkin-interacting substrate (PARIS; ZNF746), due to inactivation of parkin, contributes to Parkinson's disease (PD) through repression of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α; PPARGC1A) activity.
Autor:
Nashaat Z. Gerges, Reem Jada, Reut Shalgi, Megha Sah, Eli Rogers, Daniela Lichtman, Rachel E. Moss, Matthew A. Florence, George K.E. Umanah, Marisol Cortes, Nina S. Levy, Itamar Kahn, Alexandra Kavushansky, Randall S. Walikonis, Raz Palty, Kinneret Schragenheim-Rozales, Andrew P. Levy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
We have recently described an A350V mutation in IQSEC2 associated with intellectual disability, autism and epilepsy. We sought to understand the molecular pathophysiology of this mutation with the goal of developing targets for drug intervention. We
Autor:
Valina L. Dawson, Jia Yang, Omar Sherbini, Matthew J. Keuss, Emily Ling-Lin Pai, Hong Wang, Wei He, Ted M. Dawson, Zhikai Chi, Jianmin Zhang, Shaida A. Andrabi, Huaishan Wang, George K.E. Umanah, Kaisa M.A. Paldanius
Publikováno v:
J Cereb Blood Flow Metab
Neuronal preconditioning in vitro or in vivo with a stressful but non-lethal stimulus leads to new protein expression that mediates a profound neuroprotection against glutamate excitotoxicity and experimental stroke. The proteins that mediate neuropr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d8daa7606f5ce6056ae11e876f6af85
https://europepmc.org/articles/PMC6727130/
https://europepmc.org/articles/PMC6727130/
Autor:
Vincenzo Salpietro, Kerstin Kutsche, Henry Houlden, George K.E. Umanah, Mark I. Rees, Juliette Piard, Lionel Van Maldergem, Ted M. Dawson, Melissa Chang, Daniel Amram, Frederike L. Harms, Malik Alawi, Seo-Kyung Chung, Leire Abalde-Atristain, Alain Verloes, Rong Chen, Valina L. Dawson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764e73be0bdba420c2a66b3f2e950861
https://cronfa.swan.ac.uk/Record/cronfa39387/Download/0039387-11062018114248.pdf
https://cronfa.swan.ac.uk/Record/cronfa39387/Download/0039387-11062018114248.pdf
Autor:
Mark I. Rees, Juliette Piard, Frederike L. Harms, Henry Houlden, George K.E. Umanah, Malik Alawi, Seo-Kyung Chung, Ted M. Dawson, Valina L. Dawson, Melissa Chang, Lionel Van Maldergem, Alain Verloes, Rong Chen, Leire Abalde-Atristain, Vincenzo Salpietro, Kerstin Kutsche, Daniel Amram
Members of the AAA+ superfamily of ATPases are involved in the unfolding of proteins and disassembly of protein complexes and aggregates. ATAD1 encoding the ATPase family, AAA+ domain containing 1-protein Thorase plays an important role in the functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba8a6cee19056d611cfea5f50f0f86e
http://hdl.handle.net/11567/981581
http://hdl.handle.net/11567/981581
Autor:
Mikhail V. Pletnikov, Leslie A. Scarffe, Shaida A. Andrabi, Stewart Neifert, Xiling Yin, Ted M. Dawson, Valina L. Dawson, Cibele Canal Castro, David Valle, Joshua Crawford, Li Chen, Marco Pignatelli, Rong Chen, Erica Ma, Adam A. Behensky, Antonello Bonci, Noah Guiberson, Dimitrios Avramopoulos, Ann E. Pulver, Jin Wan Kim, Melissa Chang, George K.E. Umanah, Xiaobo Mao
Publikováno v:
Science Translational Medicine. 9
The AAA+ adenosine triphosphatase (ATPase) Thorase plays a critical role in controlling synaptic plasticity by regulating the expression of surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). Bidirectional sequencing of
Autor:
Jillian Prendergast, Seung Wan Yoo, Olof Lagerlöf, George K.E. Umanah, Ronald L. Schnaar, Robert N. Cole, Ted M. Dawson, Valina L. Dawson, Mary G. Motari, Richard L. Huganir
Publikováno v:
The Journal of Neuroscience. 34:13246-13258
Gangliosides are major cell-surface determinants on all vertebrate neurons. Human congenital disorders of ganglioside biosynthesis invariably result in intellectual disability and are often associated with intractable seizures. To probe the mechanism