Zobrazeno 1 - 10
of 43
pro vyhledávání: '"George K. Tofaris"'
Publikováno v:
Nano-Micro Letters, Vol 14, Iss 1, Pp 1-36 (2021)
Abstract Extracellular vesicles (EVs) are cell-derived membranous particles that play a crucial role in molecular trafficking, intercellular transport and the egress of unwanted proteins. They have been implicated in many diseases including cancer an
Externí odkaz:
https://doaj.org/article/0e94b871b3eb4599b6e367ae0c7d8eb0
Autor:
Benedict Tanudjojo, Samiha S. Shaikh, Alexis Fenyi, Luc Bousset, Devika Agarwal, Jade Marsh, Christos Zois, Sabrina Heman-Ackah, Roman Fischer, David Sims, Ronald Melki, George K. Tofaris
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
α-Synuclein aggregation contributes to Parkinson’s disease and related disorders. Here the authors investigate patterns of α-synuclein aggregation in human dopaminergic neurons in response to fibrils derived from individuals with Parkinson’s di
Externí odkaz:
https://doaj.org/article/ba1ca4aa1df444ff85f3d901ea6d3c50
Autor:
Hugo J.R. Fernandes, Elizabeth M. Hartfield, Helen C. Christian, Evangelia Emmanoulidou, Ying Zheng, Heather Booth, Helle Bogetofte, Charmaine Lang, Brent J. Ryan, S. Pablo Sardi, Jennifer Badger, Jane Vowles, Samuel Evetts, George K. Tofaris, Kostas Vekrellis, Kevin Talbot, Michele T. Hu, William James, Sally A. Cowley, Richard Wade-Martins
Publikováno v:
Stem Cell Reports, Vol 6, Iss 3, Pp 342-356 (2016)
Heterozygous mutations in the glucocerebrosidase gene (GBA) represent the strongest common genetic risk factor for Parkinson's disease (PD), the second most common neurodegenerative disorder. However, the molecular mechanisms underlying this associat
Externí odkaz:
https://doaj.org/article/20acb6da0a224454831f8f80ba1147cd
Autor:
Sian E. Davies, Penelope J. Hallett, Thomas Moens, Gaynor Smith, Emily Mangano, Hyoung Tae Kim, Alfred L. Goldberg, Ji-Long Liu, Ole Isacson, George K. Tofaris
Publikováno v:
Neurobiology of Disease, Vol 64, Iss , Pp 79-87 (2014)
Parkinson's disease is a neurodegenerative disorder, characterized by accumulation and misfolding of α-synuclein. Although the level of α-synuclein in neurons is fundamentally linked to the onset of neurodegeneration, multiple pathways have been im
Externí odkaz:
https://doaj.org/article/63ba3b037e504a3e927143b3a60e5222
Publikováno v:
Analytical Chemistry. 95:7906-7913
Autor:
Aikaterini Vezyroglou, Rhoda Akilapa, Katy Barwick, Saskia Koene, Catherine A. Brownstein, Muriel Holder-Espinasse, Andrew E. Fry, Andrea H. Németh, George K. Tofaris, Eleanor Hay, Imelda Hughes, Sahar Mansour, Santosh R. Mordekar, Miranda Splitt, Peter D. Turnpenny, Demetria Demetriou, Tamara T. Koopmann, Claudia A.L. Ruivenkamp, Pankaj B. Agrawal, Lucinda Carr, Virginia Clowes, Neeti Ghali, Susan Elizabeth Holder, Jessica Radley, Alison Male, Sanjay M. Sisodiya, Manju A. Kurian, J. Helen Cross, Meena Balasubramanian
Publikováno v:
Neurology, 99(14), E1511-E1526. LIPPINCOTT WILLIAMS & WILKINS
Background and ObjectivesATP1A3 is associated with a broad spectrum of predominantly neurologic disorders, which continues to expand beyond the initially defined phenotypes of alternating hemiplegia of childhood, rapid-onset dystonia parkinsonism, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23883a196d3c5ae16dc2de06f170846
https://hdl.handle.net/1887/3562155
https://hdl.handle.net/1887/3562155
Publikováno v:
Analytical Chemistry
The egress of α-synuclein in neuronally derived exosomes predates the clinical presentation of Parkinson’s disease (PD), offering a means of developing a predictive or prognostic test. Here, we report the reagentless impedimetric assay of two inte
Autor:
Cheng Jiang, Alessandro Padovani, Michele T.M. Hu, Jason J. Davis, John W. Ryder, Franziska Hopfner, Antigoni Katsikoudi, George K. Tofaris, Barbara Borroni, Daniela Berg, Gregor Kuhlenbaeumer, Samuel Evetts, Guenther Deuschl, Candan Catli, Hong Wang, Robert Hein, Yongzhi Huang
Publikováno v:
Journal of Neurology, Neurosurgery, and Psychiatry
ObjectiveParkinson’s disease is characterised neuropathologically by α-synuclein aggregation. Currently, there is no blood test to predict the underlying pathology or distinguish Parkinson’s from atypical parkinsonian syndromes. We assessed the
Autor:
Aikaterini, Vezyroglou, Rhoda, Akilapa, Katy, Barwick, Saskia, Koene, Catherine A, Brownstein, Muriel, Holder-Espinasse, Andrew E, Fry, Andrea H, Németh, George K, Tofaris, Eleanor, Hay, Imelda, Hughes, Sahar, Mansour, Santosh R, Mordekar, Miranda, Splitt, Peter D, Turnpenny, Demetria, Demetriou, Tamara T, Koopmann, Claudia A L, Ruivenkamp, Pankaj B, Agrawal, Lucinda, Carr, Virginia, Clowes, Neeti, Ghali, Susan Elizabeth, Holder, Jessica, Radley, Alison, Male, Sanjay M, Sisodiya, Manju A, Kurian, J Helen, Cross, Meena, Balasubramanian
Publikováno v:
Neurology. 99(14)
Undiagnosed individuals withTwenty-four individuals with a previously undiagnosed neurologic phenotype were found to carry 21Our study shows that looking for a combination of paroxysmal events, hyperkinesia, neuropsychiatric symptoms, and cognitive i