Zobrazeno 1 - 10
of 36
pro vyhledávání: '"George K. Szabo"'
Autor:
Raymon Durso, Barbara A. Evans, Thomas R. Browne, Ephraim G. Josephs, H. H. Fernandez, George K. Szabo, James E. Evans
Publikováno v:
The Journal of Clinical Pharmacology. 40:854-860
Carbidopa (CD), a competitive inhibitor of aromatic l-amino acid decarboxylase that does not cross the blood-brain barrier, is routinely administered with levodopa (LD) to patients with Parkinson disease (PD) to reduce the peripheral decarboxylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd62070b7a4f2c94243e649f1819b63
https://doi.org/10.1177/00912700022009585
https://doi.org/10.1177/00912700022009585
Publikováno v:
The Journal of Clinical Pharmacology. 33:246-252
Stable isotope labeling in therapeutic and subtherapeutic quantities of drug (15N2(13)C-phenobarbital) can be quantitated in biological matrices (urine) and high performance liquid chromatography (HPLC) peaks from urine using continuous-flow isotope-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e02cef851167974d1a6d4fb1fc76fe8
https://doi.org/10.1002/j.1552-4604.1993.tb03951.x
https://doi.org/10.1002/j.1552-4604.1993.tb03951.x
Autor:
Gerald E. Schumacher, George K. Szabo, Thomas R. Browne, David J. Greenblatt, James E. Evans, Barbara A. Evans
Publikováno v:
The Journal of Clinical Pharmacology. 32:1141-1145
The authors show that for a drug cleared by one enzyme the area under the serum concentration-time curve from time 0 to infinity (AUC0-INF) of a test dose can be expressed as AUC0-INF = TD x F x (Km + C)/Vmax where TD is test dose size, F is fraction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e20c92e60233608291bc37e85c093b84
https://doi.org/10.1177/009127009203201214
https://doi.org/10.1177/009127009203201214
Autor:
Thomas R. Browne, George K. Szabo, Wendy R. Galpern, Lawrence G. Miller, David J. Greenblatt, Richard I. Shader
Publikováno v:
Biochemical Pharmacology. 42:S99-S104
Clinical studies suggest that carbamazepine may attenuate effects of alprazolam discontinuation. Since discontinuation of chronic alprazolam in a mouse model is associated with behavioral alterations and upregulation at the gamma-aminobutyric acidA (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::783a92508dfaee6198ff663bf0bff2c6
https://doi.org/10.1016/0006-2952(91)90398-o
https://doi.org/10.1016/0006-2952(91)90398-o
Publikováno v:
Journal of Chromatography A. 535:279-285
Accurate urinary measurements of the two major metabolites of phenytoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) and 5-(3,4-dihydroxy-cyclohexa-1,5-dienyl)-5-phenylhydantoin (dihydrodiol, DHD), are necessary for pharmacokinetic and drug-intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c89320a22a7315217c738854735bc5
https://doi.org/10.1016/s0021-9673(01)88953-6
https://doi.org/10.1016/s0021-9673(01)88953-6
Autor:
Gerald E. Schumacher, Carol T. Walsh, Thomas R. Browne, James E. Evans, Barbara A. Evans, George K. Szabo
Publikováno v:
The Journal of Clinical Pharmacology. 30:578-584
We show that for drugs metabolized by one enzyme the slope of a plot of serum concentration (C) versus 1/clearance (CL) is linear with a value of 1/Vmax in the presence of substrate saturation and may be linear (rarely) or curved (usually) with a slo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f88704730c45e6db7ee70bbb8dfd6fab
https://doi.org/10.1002/j.1552-4604.1990.tb01859.x
https://doi.org/10.1002/j.1552-4604.1990.tb01859.x
Publikováno v:
The Journal of Clinical Pharmacology. 30:482-488
An equation is derived to estimate mean steady state serum concentration (Css) from trough steady state serum concentration (Cmin) which can be used for drugs with either linear or nonlinear pharmacokinetic properties. In 15 subjects receiving phenyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c0fda96ff0cca2ff33bb310225e8e0
https://doi.org/10.1002/j.1552-4604.1990.tb03612.x
https://doi.org/10.1002/j.1552-4604.1990.tb03612.x
Publikováno v:
Journal of clinical pharmacology. 38(4)
We propose performing human mass balance studies by administering stable isotope labeled ( 13 C or 15 N) drug and quantitating excess (above background) 13 C or 15 N in urine, serum, and feces by continuous flow-isotope ratio mass spectrometry (CF-IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6b9fe6588f2dfd13bb310ad335710d
https://pubmed.ncbi.nlm.nih.gov/9590457
https://pubmed.ncbi.nlm.nih.gov/9590457
Autor:
Ephraim G. Josephs, Dana Jennings, George K. Szabo, Barbara A. Evans, James E. Evans, Raymon Durso, Thomas R. Browne, Joseph S. Handler
Publikováno v:
Annals of neurology. 42(3)
We report the use of a new stable isotope-labeled form of levodopa (LD) to examine in vivo central LD metabolism in Parkinson's disease (PD). Eight patients representing a wide spectrum of disease severity were administered 50 mg of carbidopa orally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49474ef53486cd62c3f3c11d732259c8
https://pubmed.ncbi.nlm.nih.gov/9307250
https://pubmed.ncbi.nlm.nih.gov/9307250
Publisher Summary This chapter reviews the work to develop simple general methods for performing a mass balance/metabolite identification (MB/MI) study on any new drug using stable isotope labeling (SIL) and detection as an alternative to radioactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26725ca522a848aa21f5de39a7f50e7c
https://doi.org/10.1016/s0165-7208(97)80158-4
https://doi.org/10.1016/s0165-7208(97)80158-4
