Zobrazeno 1 - 10
of 510
pro vyhledávání: '"George K. Radda"'
Autor:
Mathangi Palanivel, Ajay Kumar, Kah-Leong Lim, Balázs Gulyás, George K. Radda, Parasuraman Padmanabhan, Domokos Máthé
Publikováno v:
Emerging Topics in Life Sciences
Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), affect the ageing population worldwide and while severely impairing the quality of life of millions, they also cause a massive economic burden to coun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e325d39940d0e9f5a29a4843ee62a1f6
https://doi.org/10.1042/etls20190141
https://doi.org/10.1042/etls20190141
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Emerging studies have recently shown the potential importance of ketone bodies in cardio-metabolic health. However, techniques to determine myocardial ketone body utilization in vivo are lacking. In this work, we developed a novel method to assess my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd137d014093f3b97d73e92ef709022
http://link.springer.com/article/10.1038/s41598-019-39378-w
http://link.springer.com/article/10.1038/s41598-019-39378-w
Autor:
Wenjie Qiu, Kenneth Wee, Kosuke Takeda, Xuemei Lim, Shigeki Sugii, George K Radda, Weiping Han
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57874 (2013)
BACKGROUND: While pathogenic mutations in BSCL2/Seipin cause congenital generalized lipodystrophy, the underlying mechanism is largely unknown. In this study, we investigated whether and how the pathogenic missense A212P mutation of Seipin (Seipin-A2
Externí odkaz:
https://doaj.org/article/7dadbd2eca9b4221bbd720d744a74645
Autor:
Sundramurthy Kumar, Parasuraman Padmanabhan, Sachin Mishra, Balázs Gulyás, George K. Radda, Narayanan Karthikeyan
Publikováno v:
Molecular Neurobiology. 56:2559-2578
The progressive loss of structure and function of neurons causes various neurodegenerative diseases which need to be examined using measurable indicators, known as biomarkers. Proteins are the building blocks for the cell and are essential as they pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501dc32eb0f3da0a35ee6a3883513120
https://doi.org/10.1007/s12035-018-1232-4
https://doi.org/10.1007/s12035-018-1232-4
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26671 (2011)
BACKGROUND:Secretion of insulin and glucagon is triggered by elevated intracellular calcium levels. Although the precise mechanism by which the calcium signal is coupled to insulin and glucagon granule exocytosis is unclear, synaptotagmin-7 has been
Externí odkaz:
https://doaj.org/article/0d079fbd1d7948c8b0810451cc6fd979
Autor:
Natalia Gustavsson, Xiaorui Wang, Yue Wang, Tingting Seah, Jun Xu, George K Radda, Thomas C Südhof, Weiping Han
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15414 (2010)
BACKGROUND:Insulin secretion is a complex and highly regulated process. It is well established that cytoplasmic calcium is a key regulator of insulin secretion, but how elevated intracellular calcium triggers insulin granule exocytosis remains unclea
Externí odkaz:
https://doaj.org/article/223a38ed5b2c42dab7e505e0d55d30ec
Autor:
Phing-How Lou, Guoqing Yang, Lu Huang, Yunxia Cui, Tiffany Pourbahrami, George K Radda, Cai Li, Weiping Han
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11669 (2010)
Soluble leptin receptor (OBRe), one of several leptin receptor isoforms, is the only bona fide leptin binding protein in plasma. Our earlier studies demonstrated that OBRe modulates leptin levels in circulation. Both clinical and in vitro studies hav
Externí odkaz:
https://doaj.org/article/5ca1eafd8c1d4bec949ffbda22764968
Publikováno v:
Oncotarget
Serine-glycine biosynthetic pathway diverts the glycolytic intermediate 3-phosphoglycerate to synthesize serine and glycine, of which the latter was found to correlate with cancer cell proliferation. Increased de novo biosynthesis of glycine by serin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf587f1346f4ff0c199529f58cf297de
https://doi.org/10.18632/oncotarget.10415
https://doi.org/10.18632/oncotarget.10415
Autor:
Desiree, Abdurrachim, Chern Chiuh, Woo, Xing Qi, Teo, Wei Xin, Chan, George K, Radda, Philip Teck Hock, Lee
Publikováno v:
Scientific Reports
Emerging studies have recently shown the potential importance of ketone bodies in cardio-metabolic health. However, techniques to determine myocardial ketone body utilization in vivo are lacking. In this work, we developed a novel method to assess my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2085600abd88f4025691d3c227b887dc
https://pubmed.ncbi.nlm.nih.gov/30940842
https://pubmed.ncbi.nlm.nih.gov/30940842
Publikováno v:
NMR in Biomedicine. 28:1021-1030
In vivo metabolic imaging using hyperpolarized [1-13C]pyruvate provides localized biochemical information and is particularly useful in detecting early disease changes, as well as monitoring disease progression and treatment response. However, a majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2c52aa0a13882a8d5e2b8d518d36b03
https://doi.org/10.1002/nbm.3346
https://doi.org/10.1002/nbm.3346