Zobrazeno 1 - 10
of 370
pro vyhledávání: '"George K. Michalopoulos"'
Autor:
Shehnaz Bano, Matthew A. Copeland, John W. Stoops, Anne Orr, Siddhi Jain, Shirish Paranjpe, Raja Gopal Reddy Mooli, Sadeesh K. Ramakrishnan, Joseph Locker, Wendy M. Mars, George K. Michalopoulos, Bharat Bhushan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 4, Pp 101380- (2024)
Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most prevalent chronic liver disorder, with no approved treatment. Our previous work demonstrated the efficacy of a pan-ErbB inhibitor, Canertinib, in
Externí odkaz:
https://doaj.org/article/f29f693fd932476384c13a2ebe3c29a5
Autor:
Sowmya Mekala, Ravi Rai, Samantha Loretta Reed, Bill Bowen, George K. Michalopoulos, Joseph Locker, Reben Raeman, Michael Oertel
Publikováno v:
Cells, Vol 13, Iss 7, p 649 (2024)
Background/Aim: Activin A is involved in the pathogenesis of human liver diseases, but its therapeutic targeting is not fully explored. Here, we tested the effect of novel, highly specific small-molecule-based activin A antagonists (NUCC-474/555) in
Externí odkaz:
https://doaj.org/article/645a524c9cd2403da680adf786157b77
Autor:
Rodrigo M. Florentino, Nicolas A. Fraunhoffer, Kazutoyo Morita, Kazuki Takeishi, Alina Ostrowska, Abhinav Achreja, Olamide Animasahun, Nils Haep, Shohrat Arazov, Nandini Agarwal, Alexandra Collin de l'Hortet, Jorge Guzman‐Lepe, Edgar N. Tafaleng, Amitava Mukherjee, Kris Troy, Swati Banerjee, Shirish Paranjpe, George K. Michalopoulos, Aaron Bell, Deepak Nagrath, Sarah J. Hainer, Ira J. Fox, Alejandro Soto‐Gutierrez
Publikováno v:
Hepatology Communications, Vol 4, Iss 6, Pp 859-875 (2020)
Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor that plays a critical role in hepatocyte function, and HNF4α‐based reprogramming corrects terminal liver failure in rats with chronic liver disease. In the livers of patients wit
Externí odkaz:
https://doaj.org/article/a366b3ff63454cfe85adee4824c052ae
Autor:
Dushani L. Palliyaguru, Li Yang, Dionysios V. Chartoumpekis, Stacy G. Wendell, Marco Fazzari, John J. Skoko, Yong Liao, Steffi Oesterreich, George K. Michalopoulos, Thomas W. Kensler
Publikováno v:
Nutrients, Vol 12, Iss 8, p 2282 (2020)
Elevated levels of estrogen are a risk factor for breast cancer. In addition to inducing DNA damage, estrogens can enhance cell proliferation as well as modulate fatty acid metabolism that collectively contributes to mammary tumorigenesis. Sulforapha
Externí odkaz:
https://doaj.org/article/031f824359b64f1088600a80cca6ba46
Publikováno v:
Cells, Vol 1, Iss 4, Pp 1261-1292 (2012)
Liver regeneration is a complex phenomenon aimed at maintaining a constant liver mass in the event of injury resulting in loss of hepatic parenchyma. Partial hepatectomy is followed by a series of events involving multiple signaling pathways controll
Externí odkaz:
https://doaj.org/article/6507efc554fa4b3e959f8703a41c328f
Autor:
George K. Michalopoulos
Publikováno v:
Cell Transplantation, Vol 15 (2006)
The availability of new cell culture, cell transplantation, and gene expression technology has highlighted a role of hepatocytes as facultative stem cells for the biliary epithelium. In addition, hepatocytes can revert to primitive progenitor cell ty
Externí odkaz:
https://doaj.org/article/256b25eb57ff4f21b7bdba27825b1519
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0282358 (2023)
[This corrects the article DOI: 10.1371/journal.pone.0059836.].
Externí odkaz:
https://doaj.org/article/608cf6a1981d45fea296857e5471a9e0
Autor:
Kelly Koral, Bharat Bhushan, Anne Orr, John Stoops, William C. Bowen, Matthew A. Copeland, Joseph Locker, Wendy M. Mars, George K. Michalopoulos
Publikováno v:
The American Journal of Pathology. 192:887-903
Activation of constitutive androstane receptor (CAR) transcription factor by xenobiotics promotes hepatocellular proliferation, promotes hypertrophy without liver injury, and induces drug metabolism genes. Previous work demonstrated that lymphocyte-s
Autor:
Callie A Norris, Mu He, Liang-I Kang, Michael Qi Ding, Josiah E Radder, Meagan M Haynes, Yu Yang, Shirish Paranjpe, William C Bowen, Anne Orr, George K Michalopoulos, Donna B Stolz, Wendy M Mars
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224498 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0096053.].
Externí odkaz:
https://doaj.org/article/390c9c66ee494f58ad59fcb9741f5941
Autor:
Jian-Hua Luo, George K. Michalopoulos, Hui Wang, Chuanyue Wu, Joel Nelson, Yan P. Yu, Yu-Chen Han
Supplementary Figures 1-2 from Interaction of Integrin-Linked Kinase and Miniature Chromosome Maintenance 7–Mediating Integrin α7 Induced Cell Growth Suppression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50eeed37d436122aa1bf53cd6f20a275
https://doi.org/10.1158/0008-5472.22381886.v1
https://doi.org/10.1158/0008-5472.22381886.v1