Zobrazeno 1 - 10
of 274
pro vyhledávání: '"George K. Lewis"'
Autor:
Andrew R. Crowley, Matthew R. Mehlenbacher, Mohammad M. Sajadi, Anthony L. DeVico, George K. Lewis, Margaret E. Ackerman
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody-mediated effector functions are widely considered to unfold according to an associative model of IgG-Fcγ receptor (FcγR) interactions. The associative model presupposes that Fc receptors cannot discriminate antigen-bound IgG from f
Externí odkaz:
https://doaj.org/article/5559437caf7c436bac7eade70d7f9afd
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Rapid detection of microbial-induced cellular changes during the course of an infection is critical to understanding pathogenesis and immunological homeostasis. In the last two decades, fluorescence imaging has received significant attention for its
Externí odkaz:
https://doaj.org/article/cfbd1ccd7e314fe9ac579ae4ed2091f6
Autor:
Shiwei Xu, Margaret C. Carpenter, Rachel L. Spreng, Scott D. Neidich, Sharanya Sarkar, DeAnna Tenney, Derrick Goodman, Sheetal Sawant, Shalini Jha, Brooke Dunn, M. Juliana McElrath, Valerie Bekker, Sarah V. Mudrak, Robin Flinko, George K. Lewis, Guido Ferrari, Georgia D. Tomaras, Xiaoying Shen, Margaret E. Ackerman
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-14 (2022)
Abstract Adjuvants can alter the magnitude, characteristics, and persistence of the humoral response to protein vaccination. HIV vaccination might benefit from tailored adjuvant choice as raising a durable and protective response to vaccination has b
Externí odkaz:
https://doaj.org/article/9ea7f299da3f47918d880c37d8b44de9
Autor:
Alexander M. Horspool, Emel Sen-Kilic, Aaron C. Malkowski, Scott L. Breslow, Margalida Mateu-Borras, Matthew S. Hudson, Mason A. Nunley, Sean Elliott, Krishanu Ray, Greg A. Snyder, Sarah Jo Miller, Jason Kang, Catherine B. Blackwood, Kelly L. Weaver, William T. Witt, Annalisa B. Huckaby, Gage M. Pyles, Tammy Clark, Saif Al Qatarneh, George K. Lewis, F. Heath Damron, Mariette Barbier
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
The rise of antimicrobial-resistant bacterial infections is a crucial health concern in the 21st century. In particular, antibiotic-resistant Pseudomonas aeruginosa causes difficult-to-treat infections associated with high morbidity and mortality. Un
Externí odkaz:
https://doaj.org/article/16ca99521a77434a82ba921b3d3424ac
Autor:
Mohammad M. Sajadi, Narjes Shokatpour, Madeleine Purcell, Zahra Rikhtegaran Tehrani, Allison Lankford, Allison Bathula, James D. Campbell, Elizabeth Adrianne Hammershaimb, Kristopher B. Deatrick, Casey Bor, Dawn M. Parsell, Colleen Dugan, Andrea R. Levine, Sabrina C. Ramelli, Daniel S. Chertow, Daniel L. Herr, Kapil K. Saharia, George K. Lewis, Alison Grazioli
Publikováno v:
PLoS ONE, Vol 18, Iss 4 (2023)
Background Although there have been many studies on antibody responses to SARS-CoV-2 in breast milk, very few have looked at the fate of these in the infant, and whether they are delivered to immunologically relevant sites in infants. Methods Mother/
Externí odkaz:
https://doaj.org/article/7f1d49bb291549309e6fd34b17125d04
Autor:
Hao D. Cheng, Karen G. Dowell, Chris Bailey-Kellogg, Brittany A. Goods, J. Christopher Love, Guido Ferrari, Galit Alter, Johannes Gach, Donald N. Forthal, George K. Lewis, Kelli Greene, Hongmei Gao, David C. Montefiori, Margaret E. Ackerman
Publikováno v:
Retrovirology, Vol 18, Iss 1, Pp 1-12 (2021)
Abstract Background The critical role of antibody Fc-mediated effector functions in immune defense has been widely reported in various viral infections. These effector functions confer cellular responses through engagement with innate immune cells. T
Externí odkaz:
https://doaj.org/article/4235d5a3572a4412a0a847e70b2a85c9
Autor:
William D. Tolbert, Neelakshi Gohain, Paul G. Kremer, Andrew P. Hederman, Dung N. Nguyen, Verna Van, Rebekah Sherburn, George K. Lewis, Andrés Finzi, Justin Pollara, Margaret E. Ackerman, Adam W. Barb, Marzena Pazgier
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Fc mediated effector functions of antibodies play important roles in immunotherapies and vaccine efficacy but assessing those functions in animal models can be challenging due to species differences. Rhesus macaques, Macaca mulatta (Mm) share approxi
Externí odkaz:
https://doaj.org/article/35ba42702de84fb390327cdf58ef34a5
Autor:
William D. Tolbert, Rebekah Sherburn, Neelakshi Gohain, Shilei Ding, Robin Flinko, Chiara Orlandi, Krishanu Ray, Andrés Finzi, George K. Lewis, Marzena Pazgier
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background The binding of HIV-1 Envelope glycoproteins (Env) to host receptor CD4 exposes vulnerable conserved epitopes within the co-receptor binding site (CoRBS) which are required for the engagement of either CCR5 or CXCR4 co-receptor to
Externí odkaz:
https://doaj.org/article/4e581d3880db4c9b880da896a134e7d8
Autor:
William D. Tolbert, Dung N. Nguyen, Marina Tuyishime, Andrew R. Crowley, Yaozong Chen, Shalini Jha, Derrick Goodman, Valerie Bekker, Sarah V. Mudrak, Anthony L. DeVico, George K. Lewis, James F. Theis, Abraham Pinter, M. Anthony Moody, David Easterhoff, Kevin Wiehe, Justin Pollara, Kevin O. Saunders, Georgia D. Tomaras, Margaret Ackerman, Guido Ferrari, Marzena Pazgier
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Passive transfer of monoclonal antibodies (mAbs) of human origin into Non-Human Primates (NHPs), especially those which function predominantly by a Fc-effector mechanism, requires an a priori preparation step, in which the human mAb is reengineered t
Externí odkaz:
https://doaj.org/article/ebe45cad4e6d401b8cdeec5671af1e07
Autor:
William D. Tolbert, Verna Van, Rebekah Sherburn, Marina Tuyishime, Fang Yan, Dung N. Nguyen, Sherry Stanfield-Oakley, David Easterhoff, Mattia Bonsignori, Barton F. Haynes, M. Anthony Moody, Krishanu Ray, Guido Ferrari, George K. Lewis, Marzena Pazgier
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/a3aede5c798f4a84814384d63df5d152