Zobrazeno 1 - 10
of 14
pro vyhledávání: '"George K. Annor"'
Autor:
George K. Annor, Nour Elshabassy, Devon Lundine, Don-Gerard Conde, Gu Xiao, Viola Ellison, Jill Bargonetti
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
The TP53 gene is often mutated in cancer, with missense mutations found in the central DNA binding domain, and less often in the C-terminal oligomerization domain (OD). These types of mutations are found in patients with the rare inherited cancer pre
Externí odkaz:
https://doaj.org/article/43c728f37129456c94c03c1a6bf4997b
Autor:
Devon Lundine, George K. Annor, Valery Chavez, Styliana Maimos, Zafar Syed, Shuhong Jiang, Viola Ellison, Jill Bargonetti
Publikováno v:
Mol Cancer Res
The TP53 gene is mutated in 80% of triple-negative breast cancers. Cells that harbor the hot-spot p53 gene mutation R273H produce an oncogenic mutant p53 (mtp53) that enhances cell proliferative and metastatic properties. The enhanced activities of m
Autor:
Jill Bargonetti, Viola Ellison, Shuhong Jiang, Zafar Syed, Styliana Maimos, Valery Chavez, George K. Annor, Devon Lundine
Supplementary Figure from The C-terminus of Gain-of-Function Mutant p53 R273H Is Required for Association with PARP1 and Poly-ADP-Ribose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00027a90e631b7daaf20b6c199ddbf1b
https://doi.org/10.1158/1541-7786.22527540
https://doi.org/10.1158/1541-7786.22527540
Autor:
Jill Bargonetti, Alexander Mazo, Olufunmilayo I. Olopade, Galina F. Khramtsova, Thomas Reiner, Patrick L. Donabedian, Alla Polotskaia, Viola Ellison, Jorge Canar, George K. Annor, Devon Lundine, Gu Xiao
S3 Mutant p53/PARP and Mutant p53/Edu Complexes in MDA-MB-468 and PANC-1 Cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eac70e9b64f0f76e80d42894c091f42
https://doi.org/10.1158/0008-5472.22425127.v1
https://doi.org/10.1158/0008-5472.22425127.v1
Autor:
Jill Bargonetti, Alexander Mazo, Olufunmilayo I. Olopade, Galina F. Khramtsova, Thomas Reiner, Patrick L. Donabedian, Alla Polotskaia, Viola Ellison, Jorge Canar, George K. Annor, Devon Lundine, Gu Xiao
S2 Mutant p53 R273H and Flag-R248W associate with replicating DNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aeed6b59b649882045e2d32d668ad6b
https://doi.org/10.1158/0008-5472.22425130.v1
https://doi.org/10.1158/0008-5472.22425130.v1
Autor:
Jill Bargonetti, Alexander Mazo, Olufunmilayo I. Olopade, Galina F. Khramtsova, Thomas Reiner, Patrick L. Donabedian, Alla Polotskaia, Viola Ellison, Jorge Canar, George K. Annor, Devon Lundine, Gu Xiao
Over 80% of triple-negative breast cancers (TNBC) express mutant p53 (mtp53) and some contain oncogenic gain-of-function (GOF) p53. We previously reported that GOF mtp53 R273H upregulates the chromatin association of mini chromosome maintenance (MCM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af203c4bf97f75ab84bf2c577e20a0bd
https://doi.org/10.1158/0008-5472.c.6511948.v1
https://doi.org/10.1158/0008-5472.c.6511948.v1
Autor:
Jill Bargonetti, Alexander Mazo, Olufunmilayo I. Olopade, Galina F. Khramtsova, Thomas Reiner, Patrick L. Donabedian, Alla Polotskaia, Viola Ellison, Jorge Canar, George K. Annor, Devon Lundine, Gu Xiao
S1 Chromatin protein levels of mtp53, H2B and Lamin A were compared by Western blot analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030f274c4727416e34eb619eafc7b9c0
https://doi.org/10.1158/0008-5472.22425133
https://doi.org/10.1158/0008-5472.22425133
Autor:
Jill Bargonetti, Alexander Mazo, Olufunmilayo I. Olopade, Galina F. Khramtsova, Thomas Reiner, Patrick L. Donabedian, Alla Polotskaia, Viola Ellison, Jorge Canar, George K. Annor, Devon Lundine, Gu Xiao
S4 Examples of manually scored p53 and PARP1 staining intensity categories.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3258456787ea93aabe7f57f4c125b8b9
https://doi.org/10.1158/0008-5472.22425124.v1
https://doi.org/10.1158/0008-5472.22425124.v1
Autor:
Clara Freedman, Gu Xiao, Viola Ellison, Carol Prives, Jill Bargonetti, Devon Lundine, Elzbieta Freulich, George K. Annor
Publikováno v:
Oncotarget
We recently documented that gain-of-function (GOF) mutant p53 (mtp53) R273H in triple negative breast cancer (TNBC) cells interacts with replicating DNA and PARP1. The missense R273H GOF mtp53 has a mutated central DNA binding domain that renders it
Publikováno v:
Mol Pharm
Triple negative breast cancer (TNBC) has no targeted detection or treatment method. Mutant p53 (mtp53) is overexpressed in >80% of TNBCs, and the stability of mtp53 compared to the instability of wild-type p53 (wtp53) in normal cells makes mtp53 a pr