Zobrazeno 1 - 10
of 260
pro vyhledávání: '"George K. Aghajanian"'
Publikováno v:
Biological Psychiatry. 90:85-95
The discovery of the rapid-acting antidepressant effects of ketamine has 1) led to a paradigm shift in our perception of what is possible in treating severe depression; 2) spurred a wave of basic, translation, and clinical research; and 3) provided a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdf2b9088f78452323bfb7932651edd
https://doi.org/10.1016/j.biopsych.2020.12.006
https://doi.org/10.1016/j.biopsych.2020.12.006
Publikováno v:
Nature Medicine. 22:238-249
Depression is a common, devastating illness. Current pharmacotherapies help many patients, but high rates of a partial response or no response, and the delayed onset of the effects of antidepressant therapies, leave many patients inadequately treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218c61830950926fa14a07e70ed88e3f
https://doi.org/10.1038/nm.4050
https://doi.org/10.1038/nm.4050
Publikováno v:
Neuropsychopharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79beeb48120e7f09ecbea4ca6066bc4
https://doi.org/10.1038/s41386-020-0770-4
https://doi.org/10.1038/s41386-020-0770-4
Autor:
Ralph J. DiLeone, Eric S. Wohleb, Benjamin B. Land, Rong-Jian Liu, Ronald S. Duman, Manabu Fuchikami, Alexandra M. Thomas, George K. Aghajanian
Publikováno v:
Proceedings of the National Academy of Sciences. 112:8106-8111
Ketamine produces rapid and sustained antidepressant actions in depressed patients, but the precise cellular mechanisms underlying these effects have not been identified. Here we determined if modulation of neuronal activity in the infralimbic prefro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73ada749b3b4e1195a72524fbd70485
https://doi.org/10.1073/pnas.1414728112
https://doi.org/10.1073/pnas.1414728112
Publikováno v:
Neuropsychopharmacology. 40:2066-2075
A single sub-anesthetic dose of ketamine, a short-acting NMDA receptor blocker, induces a rapid and prolonged antidepressant effect in treatment-resistant major depression. In animal models, ketamine (24 h) reverses depression-like behaviors and asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded2903abd92fb160540d82e968f5b7e
https://doi.org/10.1038/npp.2015.70
https://doi.org/10.1038/npp.2015.70
Autor:
Steven Ray Boikess, Craig A. Stockmeier, David A. Lewis, Ralph J. DiLeone, Vanja Duric, Bhavya Voleti, Kristie T. Ota, Rong-Jian Liu, Sophie Dutheil, Jaime G. Maldonado-Avilés, Masaaki Iwata, George K. Aghajanian, Ronald S. Duman, Christopher S. Rex, Catharine H. Duman
Publikováno v:
Nature Medicine. 20:531-535
Major depressive disorder (MDD) affects up to 17% of the population, causing profound personal suffering and economic loss. Clinical and preclinical studies have revealed that prolonged stress and MDD are associated with neuronal atrophy of cortical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77d83cc79d41dc0e290103c0d90a76f
https://doi.org/10.1038/nm.3513
https://doi.org/10.1038/nm.3513
Autor:
Ralph J. DiLeone, David M Grimaldi, Douglas J. Guarnieri, Maysa Sarhan, Nandakumar S. Narayanan, Karl Deisseroth, Rong-Jian Liu, Catherine E. Brayton, Carol A. Gianessi, Benjamin B. Land, George K. Aghajanian
Publikováno v:
Nature neuroscience
Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31c51561cd745e6f2e1780c907ce858
http://europepmc.org/articles/PMC3968853
http://europepmc.org/articles/PMC3968853
Autor:
Gerard Sanacora, Mounira Banasr, Nanxin Li, Rose Z. Terwilliger, Ronald S. Duman, Rong-Jian Liu, Andrea Navarria, Tore Eid, George K. Aghajanian, Bhavya Voleti
Publikováno v:
Biological Psychiatry. 74:742-749
Background Clinical studies report that scopolamine, an acetylcholine muscarinic receptor antagonist, produces rapid antidepressant effects in depressed patients, but the mechanisms underlying the therapeutic response have not been determined. The pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ed155a5d6e7309eccba6c5fe1fc6d20
https://doi.org/10.1016/j.biopsych.2013.04.025
https://doi.org/10.1016/j.biopsych.2013.04.025
Autor:
Manabu Fuchikami, Rong-Jian Liu, Ashley E. Lepack, George K. Aghajanian, Ronald S. Duman, Jason M. Dwyer
Publikováno v:
Neuropsychopharmacology. 38:2268-2277
A single dose of the short-acting NMDA antagonist ketamine produces rapid and prolonged antidepressant effects in treatment-resistant patients with major depressive disorder (MDD), which are thought to occur via restoration of synaptic connectivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa28e00df88e51eefee6deb0953b9b20
https://doi.org/10.1038/npp.2013.128
https://doi.org/10.1038/npp.2013.128