Zobrazeno 1 - 10
of 61
pro vyhledávání: '"George K. Abruzzo"'
Autor:
Dongfang Meng, Dann L. Parker, Robin Kirwan, M A Powles, Jennifer Nielsen Kahn, James M. Apgar, Fred Racine, Paul A. Liberator, Amy M. Flattery, Andrew Galgoci, Kingsley H. Nelson, James M. Balkovec, Andrew S. Misura, Weiming Fan, Donald M. Sperbeck, Michael Robert Peel, Robert A. Giacobbe, Mark L. Greenlee, Ahmed Mamai, Jasminka Dragovic, Kenneth J. Wildonger, Hao Liu, Robert R. Wilkening, Mary Motyl, Shu Lee, Ming-Jo Hsu, Charles Gill, George K. Abruzzo
Publikováno v:
Bioorganicmedicinal chemistry letters. 32
We previously reported medicinal chemistry efforts that identified MK-5204, an orally efficacious β-1,3-glucan synthesis inhibitor derived from the natural product enfumafungin. Further extensive optimization of the C2 triazole substituent identifie
Autor:
James M. Balkovec, Robert A. Giacobbe, Jennifer Nielsen Kahn, Ming Jo Hsu, Weiming Fan, Ahmed Mamai, Michael Robert Peel, James M. Apgar, Amy M. Flattery, Paul A. Liberator, Fred Racine, Bahanu Habulihaz, Mary Motyl, Kingsley H. Nelson, Robert R. Wilkening, Robin Kirwan, M A Powles, George K. Abruzzo, Andrew Galgoci, Charles Gill, Andrew S. Misura, Shu Lee, Jasminka Dragovic, Hao Liu, Mark L. Greenlee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5813-5818
The clinical success of the echinocandins, which can only be administered parentally, has validated β-1,3-glucan synthase (GS) as an antifungal target. Semi-synthetic modification of enfumafungin, a triterpene glycoside natural product, was performe
Autor:
George K. Abruzzo, Rena Zhang, Mary Ann Powles, Emily Hickey, Charles Gill, Andrew S. Misura, Joan D. Ellis, John Ronan, Andrew Galgoci, Punam Sandhu, Amy M. Flattery
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:3491-3497
Neonatal candidiasis is an increasingly common occurrence causing significant morbidity and mortality and a higher risk of dissemination to the central nervous system (CNS) than that seen with older patients. The current understanding of optimal anti
Autor:
Terry Roemer, Javier Collado, Deming Xu, George K. Abruzzo, Sheo B. Singh, Antonio Gonzalez, Francisca Vicente, Kithsiri Herath, Jennifer Nielsen Kahn, Scott K. Smith, Hiranthi Jayasuriya, Bo Jiang, Paul A. Liberator, Gerald F. Bills, Robert A. Giacobbe, Stefan Galuska, Emily Hickey, Deborah L. Zink, Guy H. Harris
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:1361-1369
We isolated a cyclic lipodepsipeptide, phomafungin, from a Phoma sp. The distinct antifungal activity of phomafungin in the crude extract was initially discovered by mechanistic profiling in the Candida albicans fitness test. The purified compound co
Autor:
Jennifer Nielsen Kahn, Gerald F. Bills, Paul A. Liberator, John G. Ondeyka, Bo Jiang, Mercedes de la Cruz, Deborah L. Zink, Stefan Galuska, Terry Roemer, Javier Collado, Robert A. Giacobbe, Jesús Martín, Gonzalo Platas, Sheo B. Singh, Antonio Gonzalez, Francisca Vicente, Angela Basilio, Deming Xu, George K. Abruzzo, Emily Hickey, Guy H. Harris
Publikováno v:
Journal of Natural Products. 72:136-141
A glycosylated tetramic acid, virgineone (1), was isolated from saprotrophic Lachnum virgineum. The antifungal activity of the fermentation extract of L. virgineum was characterized in the Candida albicans fitness test as distinguishable from other n
Autor:
Cameron M. Douglas, Charles Gill, Andrew S. Misura, Ming-Jo Hsu, George K. Abruzzo, T. C. Wang, Emily Hickey, Paul A. Liberator, Amy M. Flattery, J. Nielsen Kahn, Barbara A. Pelak, Joel Bowman
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:4202-4205
The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-β- d -glucan synthase from Aspergillus flavus , Aspergillus terreus , and Aspergillus nidulans . In murine models of disseminated infection, caspofungin prolonged survival and
Publikováno v:
Therapy. 3:521-526
Aims: To develop a murine model of oxazolidinone-induced myelosuppression observed in man for identification of potentially less myelosuppressive compounds within this chemical therapeutic class. Methods: Female C3H mice were treated orally, once-dai
Autor:
Emily Hickey, Joel Bowman, Bill Pikounis, George K. Abruzzo, Andrew S. Misura, Paul A. Liberator, Ken Bartizal, Cameron M. Douglas, Charles Gill
Publikováno v:
Therapy. 2:615-621
Background: Caspofungin acetate has been approved for use in empirical therapy of presumed fungal infections in febrile, neutropenic patients, candidemia, esophageal candidiasis and invasive aspergillosis in patients who cannot tolerate or respond to
Autor:
Myra B. Kurtz, Francisca Vicente, Maria Teresa Diez, Antonio González del Val, Robert E. Schwartz, Fernando Pelaez, Amy M. Flattery, Gerald F. Bills, George K. Abruzzo, Isabel Martán, Gonzalo Platas, Angela Basilio, Robert A. Giacobbe, Maria S. Meinz, Angeles Cabello, Janet C. Onishi, Li Kong
Publikováno v:
Systematic and Applied Microbiology. 23:333-343
In a screening of natural products with antifungal activity derived from endophytic fungi, we detected a potent activity in a culture belonging to the form-genus Hormonema, isolated from leaves of Juniperus communis. The compound is a new triterpene
Autor:
Jeffrey G. Smith, C. Leighton, Charles Gill, Amy M. Flattery, V. B. Pikounis, Leopold Kong, George K. Abruzzo, Hugh Rosen, Bartizal Kenneth F
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:2310-2318
The in vivo efficacy of the echinocandin antifungal caspofungin acetate (caspofungin; MK-0991) was evaluated in models of disseminated aspergillosis and candidiasis in mice with cyclophosphamide (CY)-induced immunosuppression. Caspofungin is a 1,3-β