Zobrazeno 1 - 10
of 489
pro vyhledávání: '"George K, Michalopoulos"'
Autor:
Shehnaz Bano, Matthew A. Copeland, John W. Stoops, Anne Orr, Siddhi Jain, Shirish Paranjpe, Raja Gopal Reddy Mooli, Sadeesh K. Ramakrishnan, Joseph Locker, Wendy M. Mars, George K. Michalopoulos, Bharat Bhushan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 4, Pp 101380- (2024)
Background & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most prevalent chronic liver disorder, with no approved treatment. Our previous work demonstrated the efficacy of a pan-ErbB inhibitor, Canertinib, in
Externí odkaz:
https://doaj.org/article/f29f693fd932476384c13a2ebe3c29a5
Autor:
Sowmya Mekala, Ravi Rai, Samantha Loretta Reed, Bill Bowen, George K. Michalopoulos, Joseph Locker, Reben Raeman, Michael Oertel
Publikováno v:
Cells, Vol 13, Iss 7, p 649 (2024)
Background/Aim: Activin A is involved in the pathogenesis of human liver diseases, but its therapeutic targeting is not fully explored. Here, we tested the effect of novel, highly specific small-molecule-based activin A antagonists (NUCC-474/555) in
Externí odkaz:
https://doaj.org/article/645a524c9cd2403da680adf786157b77
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0282358 (2023)
[This corrects the article DOI: 10.1371/journal.pone.0059836.].
Externí odkaz:
https://doaj.org/article/608cf6a1981d45fea296857e5471a9e0
Autor:
Rodrigo M. Florentino, Nicolas A. Fraunhoffer, Kazutoyo Morita, Kazuki Takeishi, Alina Ostrowska, Abhinav Achreja, Olamide Animasahun, Nils Haep, Shohrat Arazov, Nandini Agarwal, Alexandra Collin de l'Hortet, Jorge Guzman‐Lepe, Edgar N. Tafaleng, Amitava Mukherjee, Kris Troy, Swati Banerjee, Shirish Paranjpe, George K. Michalopoulos, Aaron Bell, Deepak Nagrath, Sarah J. Hainer, Ira J. Fox, Alejandro Soto‐Gutierrez
Publikováno v:
Hepatology Communications, Vol 4, Iss 6, Pp 859-875 (2020)
Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor that plays a critical role in hepatocyte function, and HNF4α‐based reprogramming corrects terminal liver failure in rats with chronic liver disease. In the livers of patients wit
Externí odkaz:
https://doaj.org/article/a366b3ff63454cfe85adee4824c052ae
Autor:
Callie A Norris, Mu He, Liang-I Kang, Michael Qi Ding, Josiah E Radder, Meagan M Haynes, Yu Yang, Shirish Paranjpe, William C Bowen, Anne Orr, George K Michalopoulos, Donna B Stolz, Wendy M Mars
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0224498 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0096053.].
Externí odkaz:
https://doaj.org/article/390c9c66ee494f58ad59fcb9741f5941
Autor:
Kelly Koral, Bharat Bhushan, Anne Orr, John Stoops, William C. Bowen, Matthew A. Copeland, Joseph Locker, Wendy M. Mars, George K. Michalopoulos
Publikováno v:
The American Journal of Pathology. 192:887-903
Activation of constitutive androstane receptor (CAR) transcription factor by xenobiotics promotes hepatocellular proliferation, promotes hypertrophy without liver injury, and induces drug metabolism genes. Previous work demonstrated that lymphocyte-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1dfe46acaa0e380a6a8f5e18257a63
https://doi.org/10.1016/j.ajpath.2022.03.010
https://doi.org/10.1016/j.ajpath.2022.03.010
Autor:
Jian-Hua Luo, George K. Michalopoulos, Hui Wang, Chuanyue Wu, Joel Nelson, Yan P. Yu, Yu-Chen Han
Supplementary Figures 1-2 from Interaction of Integrin-Linked Kinase and Miniature Chromosome Maintenance 7–Mediating Integrin α7 Induced Cell Growth Suppression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50eeed37d436122aa1bf53cd6f20a275
https://doi.org/10.1158/0008-5472.22381886.v1
https://doi.org/10.1158/0008-5472.22381886.v1
Autor:
Jian-Hua Luo, George K. Michalopoulos, Hui Wang, Chuanyue Wu, Joel Nelson, Yan P. Yu, Yu-Chen Han
Mutation of integrin α7 (ITGA7) was previously identified in multiple human malignancies. Restoration of ITGA7 expression in prostate cancer and leiomyosarcoma cell lines suppressed tumor growth and cell motility both in vitro and in vivo. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc3c9a46c04dbe57e584a807e3f2981f
https://doi.org/10.1158/0008-5472.c.6500015.v1
https://doi.org/10.1158/0008-5472.c.6500015.v1
Autor:
Ze-Hua Zuo, Silvia Liu, Deqin Ma, Joel B. Nelson, James D. Luketich, Paul Satdarshan Monga, George K. Michalopoulos, Qi Chen, Jianhua Luo, Yanping Yu, Rohit Bhargava, Baoguo Ren, Arjun Pennathur, Michael A. Nalesnik, Jun Zhang, Junyan Tao, Tirthadipa Pradhan-Sundd, Zhou Wang
Publikováno v:
Hepatology Communications, Vol 6, Iss 1, Pp 209-222 (2022)
Hepatology Communications
Hepatology Communications
Chromosome rearrangement is one of the hallmarks of human malignancies. Gene fusion is one of the consequences of chromosome rearrangements. In this report, we show that gene fusion between solute carrier family 45 member 2 (SLC45A2) and alpha-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842ecffab914d4727da49ac03bf0985e
https://doi.org/10.1002/hep4.1724
https://doi.org/10.1002/hep4.1724
Autor:
John Stoops, Anne Orr, Swati Banerjee, George K. Michalopoulos, Shirish Paranjpe, Bharat Bhushan, Kelly Koral, Satdarshan P.S. Monga, Wendy M. Mars, Laura Molina, Joseph Locker
Publikováno v:
Hepatology (Baltimore, Md.)
Background and aims Constitutive androstane receptor (CAR) agonists, such as 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP), are known to cause robust hepatocyte proliferation and hepatomegaly in mice along with induction of drug metabolism g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a4cc15ac6a0161c9c56e6972bc74e8
http://europepmc.org/articles/PMC7885729
http://europepmc.org/articles/PMC7885729