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REDEFINING OUTCOMES IN IMMUNE TTP: AN INTERNATIONAL WORKING GROUP CONSENSUS REPORT

Autor: Cuker A, Cataland SR, Coppo P, de la Rubia J, Friedman KD, George JN, Knoebl PN, Kremer Hovinga JA, Lämmle B, Matsumoto M, Pavenski K, Peyvandi F, Sakai K, Sarode R, Thomas M, Tomiyama Y, Veyradier A, Westwood JP, Scully M

Publikováno v: Blood
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal thrombotic microangiopathy caused by autoantibody-mediated severe deficiency of ADAMTS13. Standardized definitions of response, exacerbation, remission and relapse were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::34a2cd1011aca63a7d7d3717d0fea698
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=14029

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Bond swapping from a charge cloud allows flexible coordination of upstream signals through WASP: Multiple regulatory roles for the WASP basic region

Autor: Tetley, George JN, Szeto, Aydan, Fountain, Adam J, Mott, Helen R, Owen, Darerca

Publikováno v: The Journal of Biological Chemistry

Wiskott-Aldrich syndrome protein (WASP) activates the actin-related protein 2/3 homolog (Arp2/3) complex and regulates actin polymerization in a physiological setting. Cell division cycle 42 (Cdc42) is a key activator of WASP, which binds Cdc42 throu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::94ffddd46e0c68fa73efe235653d7c3e
http://europepmc.org/articles/PMC6166713

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Identification, characterization and purification of a 160 kD bumetanide-binding glycoprotein from the rabbit parotid

Autor: Stephan J. Reshkin, George Jn, Syng Ill Lee, R. James Turner

Publikováno v: The Journal of Membrane Biology. 136:243-251

We demonstrate the presence of a 160 kD protein in rabbit parotid basolateral membranes that can be labeled with the irreversible sulfhydryl reagent [14C]-N-ethylmaleimide in a bumetanide-protectable fashion. The specificity of this labeling, and our

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68a0fda6075c2e91019439b78de442c
https://doi.org/10.1007/bf02505766

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Solubilization and partial purification of the rabbit parotid Na/K/Cl-dependent bumetanide binding site

Autor: George Jn, Turner Rj

Publikováno v: The Journal of Membrane Biology. 113:203-210

We demonstrate that the high affinity bumetanide binding site of the rabbit parotid acinar cell can be extracted from a basolateral membrane fraction using relatively low concentrations (0.07%, wt/vol; 1 mg membrane protein/ml) of the nonionic deterg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0edb74908195b3b82c633c9d9fa8a5c3
https://doi.org/10.1007/bf01870072

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