Zobrazeno 1 - 9 of 9 pro vyhledávání: '"George J. Quellhorst"'
1
Abstract 753: Profiling of multiple RNA-based biomarkers for cancer identification
Autor: Xiujing Gu, Song Tian, Young Woo Kim, George J. Quellhorst, Scott F. Winter, Jixin Deng, Frank Reinecke, Eric Lader, Raghavendra Padmanabhan, Dan Heard, Raed Samara, James Keller, John DiCarlo, Hong Xu, Mohammad R. Nezami Ranjbar
Publikováno v: Cancer Research. 80:753-753
With the adoption of NGS as a powerful tool for molecular biology research, researchers seek to efficiently utilize genetic variation information for cancer identification which otherwise would be difficult with traditional method. For example, targe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::362ebb622f76aac7ed412b9eb6191284
https://doi.org/10.1158/1538-7445.am2020-753
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2
Defects in the N-Linked Oligosaccharide Biosynthetic Pathway in a Trypanosoma brucei Glycosylation Mutant
Autor: Jessica L. O'Rear, Sharon S. Krag, George J. Quellhorst, Paul T. Englund, Soo Hee Lee, Alvaro Acosta-Serrano, Kuo-Yuan Hwa
Publikováno v: Eukaryotic Cell. 3:255-263
Concanavalin A (ConA) kills the procyclic (insect) form of Trypanosoma brucei by binding to its major surface glycoprotein, procyclin. We previously isolated a mutant cell line, ConA 1-1, that is less agglutinated and more resistant to ConA killing t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190524d68bf915bb5bcd33adfe0d8a3d
https://doi.org/10.1128/ec.3.2.255-263.2004
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4
Modification of Rab5 with a photoactivatable analog of geranylgeranyl diphosphate
Autor: Charles M. Allen, George J. Quellhorst, Marianne Wessling-Resnick
Publikováno v: The Journal of biological chemistry. 276(44)
A photoprobe analog of geranylgeranyl diphosphate (2-diazo-3,3,3-trifluoropropionyloxy-farnesyl diphosphate or DATFP-FPP) inhibits mevalonate-dependent prenylation of in vitro translated Rab5 in rabbit reticulocyte lysate, suggesting that it competes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1685aa11e91235eb4acbfe2002f6856
https://pubmed.ncbi.nlm.nih.gov/11522782
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5
Nonglucosylated oligosaccharides are transferred to protein in MI8-5 Chinese hamster ovary cells
Autor: René Cacan, Jessica L. O'Rear, André Verbert, George J. Quellhorst, Sharon S. Krag
Publikováno v: Glycobiology. 9(1)
A CHO mutant MI8-5 was found to synthesize Man9-GlcNAc2-P-P-dolichol rather than Glc3Man9GlcNAc2-P-P-dolichol as the oligosaccharide-lipid intermediate in N-glycosylation of proteins. MI8-5 cells were incubated with labeled mevalonate, and the prenol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d84ee4f188fb4b3259cc87eaa7710c
https://pubmed.ncbi.nlm.nih.gov/9884408
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6
Synthesis of dolichol in a polyprenol reductase mutant is restored by elevation of cis-prenyl transferase activity
Autor: April R. Robbins, George J. Quellhorst, Clara W. Hall, Sharon S. Krag
Publikováno v: Archives of biochemistry and biophysics. 343(1)
CHB11-1-3 is a glycosylation mutant of Chinese hamster ovary (CHO) cells, isolated by screening mutagenized cells for those with decreased intracellular lysosomal enzyme activity [C. W. Hall et al. (1986) Mol. Cell. Biochem. 72, 35–45]. CHB11-1-3 s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3342cf88abfc28f082cad421663f072
https://pubmed.ncbi.nlm.nih.gov/9210642
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7
A gene expression signature that distinguishes malignant from benign thyroid nodules
Autor: Jiaye Yu, Michael J. Crowley, George J. Quellhorst, Raymond K. Blanchard, John DiCarlo, Vikram Devgan, Nadejda Slepushkina, Thomas J. Fahey, Song Tian, Xiao Zeng
Publikováno v: Journal of Clinical Oncology. 30:e21011-e21011
e21011 Background: Thyroid nodules can be detected in as high as 67% of the population. Distinguishing thyroid cancers from benign lesions is crucial for determining an appropriate treatment plan. For years a gene expression signature for discriminat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::871e32a38246bd2884ba7ad7400b77b8
https://doi.org/10.1200/jco.2012.30.15_suppl.e21011
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8
Abstract 149: DNA methylation biomarker discovery using the Methyl-Profiler PCR Array System
Autor: Xiujing Gu, George J. Quellhorst, Kathy Boon, Yuye Lin, Rui Han, Jonathan M. Shaffer, Yan Xiang, Chun-Xiang Liu, Guozhen Liu
Publikováno v: Cancer Research. 70:149-149
Histone modifications and DNA methylation are epigenetic events that can modulate gene expression patterns associated with normal development and disease pathology. Epigenetic alterations are clearly involved in breast cancer initiation and progressi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e88d374c256eb9a99b5cfa5978a62019
https://doi.org/10.1158/1538-7445.am10-149
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9
Abstract LB-140: An innovative approach for profiling of histone modification marks and gene expression across a panel of oncogenes and tumor suppressor genes in multiple cancer cell lines
Autor: Yan Xiang, Xiujing Gu, Xiao Zeng, Jiaqiang Huang, Kathy Boon, George J. Quellhorst
Publikováno v: Cancer Research. 70:LB-140
Objectives: Histone modification marks and gene expression profiling on multiple human oncogenes and tumor suppressor genes to study the correlation between epigenetic modifications and gene expression in cancer cells derived from different tissue/ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03f4ab174a0e724ade2776457bf0f979
https://doi.org/10.1158/1538-7445.am10-lb-140
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