Výsledky vyhledávání - "George J. Pettit"

Transcriptional regulation of insulin receptor substrate 1 by protein kinase C

Autor: J O Carey, Winifred O. Bryant, George J. Pettit, James E. deVente, D. Kirk Ways

Publikováno v: The Journal of biological chemistry. 271(50)

Insulin receptor substrate-1 (IRS-1) is involved in insulin signal transduction distal to receptor occupation. Targeted disruption of IRS-1 leads to insulin resistance and hyperglycemia in mice, which suggests that altered IRS-1 expression could cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8e51c12500a609978686bfc26eed5b
https://pubmed.ncbi.nlm.nih.gov/8943287

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Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death

Autor: George J. Pettit, Guillermina Lozano, Donald J. Fletcher, Winifred O. Bryant, Jianming Chen, D. Kirk Ways, Paul P. Cook, Cynthia A. Kukoly, James E. De Vente, Peter J. Parker, Karla J. Posekany

Protein kinase C (PKC) modulates growth, differentiation and apoptosis in a cell-specific fashion. Overexpression of PKC-alpha in MCF-7 breast cancer cells (MCF-7-PKC-alpha cell) leads to expression of a more transformed phenotype. The response of MC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52c890fd8415c3e67aa4b5add88aaed
https://europepmc.org/articles/PMC185824/

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