Zobrazeno 1 - 10
of 54
pro vyhledávání: '"George J. Jakab"'
Publikováno v:
Inhalation Toxicology. 9:601-621
The contribution of genetic background to the pathogenesis of airway responses to environmental agents including air pollutants is becoming increasingly clear. Characterization of genetic mechanisms of response to these agents may assist in the ident
Publikováno v:
Inhalation Toxicology. 8:679-694
A flow-past nose-only inhalation system is described for the coexposure of animals to carbon black aerosols (CBA) and sulfur dioxide (SO2) at varying relative humidities (RH). The conversion of (SO2 to sulfate (SO42-) on the CBA, at a fixed aerosol c
Publikováno v:
Toxicology and Applied Pharmacology. 125:198-205
Dietary aflatoxin B 1 (AFB 1 ) exposure impairs innate and acquired host defenses resulting in increased susceptibility to infections in domesticated animals. Experimental studies have confirmed this observation by demonstrating the immunosuppressive
Autor:
David R. Hemenway, George J. Jakab
Publikováno v:
Inhalation Toxicology. 5:275-289
Acrolein, a hydrophilic vapor that is efficiently absorbed in the upper respiratory tract, is often emitted with respirable particles by combustion sources. If acrolein is adsorbed on respirable particles it may be deposited in the deep lung and inte
Autor:
George J. Jakab, David R. Hemenway
Publikováno v:
Journal of Toxicology and Environmental Health. 37:11-24
Inhalation exposure to silicon dioxide is known to result in acute lung injury followed by pulmonary fibrosis. Recently it has been shown that the acute lung damage during influenza virus infection is also followed by a fibrogenic process. To investi
Publikováno v:
Experimental Lung Research. 17:547-558
Short-term exposures to ozone (O3) are known to impair pulmonary antibacterial defenses and alveolar macrophage (AM) phagocytosis in a dose-related manner. To determine the effect of prolonged O3 exposure, Swiss mice were exposed continuously to 0.5
Autor:
George J. Jakab, M.I. Gilmour
Publikováno v:
Inhalation Toxicology. 3:293-308
Ozone has been shown to both enhance and suppress local and systemic immune responses, depending upon the experimental conditions and the immune parameters under investigation. To gain insight into this apparent immunomodulation, mice were continuous
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 258:L313-L320
We examined ozone-induced airway inflammatory responses in inbred mice, and progeny of crosses between them, to investigate genetic susceptibility to ozone. Nine strains of male mice (18–23 g, 5–7 wk) were exposed for 3 h to 2 ppm ozone (O3) or f
Autor:
Robert R. Hmieleski, Terence H. Risby, George J. Jakab, Jane E. Farrington, Shelley S. Sehnert
Publikováno v:
Environmental Health Perspectives
Alveolar macrophages were treated with carbon blacks and adsorbates in order to evaluate the biologic effect of adsorbate, adsorbent and adsorbate-adsorbent complexes. Their capacity to phagocytize a subsequent challenge via the Fc-membrane receptor
Autor:
Terence H. Risby, Shelley S. Sehnert, David R. R. Hernenway, Robert Hrnieleski, George J. Jakab, Stephen M. Bowes
Publikováno v:
Inhalation Toxicology. 2:69-89
The purpose of this research was to develop a nose-only inhalation toxicology system for exposing animals to carbon black and formaldehyde—both individually and in combination. This study discusses the modifications necessary to use a fluidized-bed