Zobrazeno 1 - 10
of 25
pro vyhledávání: '"George J. Cardinale"'
Publikováno v:
Biochemical and Biophysical Research Communications. 73:1056-1062
Prolyl hydroxylase and an immunologically related protein (CRP) were purified from neonatal rabbit skin at various time periods following administration of 3H-leucine. The peak incorporation of label into prolyl hydroxylase was found to be 12 hours,
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 543:116-122
L-929 and 3T6 cells were conditioned to grow in a chemically defined medium lacking serum and ascorbate. Serum, when added, had a small stimulatory effect on the growth rate of the cells, but ascorbate had no effect either on the growth rate or on th
Publikováno v:
Proceedings of the National Academy of Sciences. 75:1379-1383
Immunoglobulin-producing Merwin plasma cells, MPC-11, have been found to contain proplyl hydroxylase (prolyl-glycyl-peptide,2-oxoglutarate:oxygen oxidoreductase; EC 1.14.11.2) activity and its crossreacting protein, as well as hydroxyproline and a co
Prolyl hydroxylase half reaction: peptidyl prolyl-independent decarboxylation of alpha-ketoglutarate
Publikováno v:
Proceedings of the National Academy of Sciences. 75:2145-2149
Prolyl hydroxylase (proline,2-oxoglutarate dioxygenase, EC 1.14.11.2) is a mixed-function oxygenase that hydroxylates peptidyl proline with the simultaneous and stoichiometric decarboxylation of alpha-ketoglutarate to succinate and CO2. It has been f
Autor:
Kazuhiro Oka, A. Donald Finck, Joel D. Kantrowitz, Josef Donnerer, Sydney Spector, George J. Cardinale
Publikováno v:
Life Sciences. 40:301-306
We have examined cerebrospinal fluid (CSF) from twelve patients who were not on any medication and found them to contain both morphine and codeine in concentrations of 2 to 339 fmol/ml. These are comparable to the concentration of opioid peptides in
Publikováno v:
Biochemical and Biophysical Research Communications. 64:947-954
An in vitro increase in prolyl hydroxylase activity has been effected in sonicates of early log phase L 929 mouse skin fibroblasts from either monolayer or suspension cultures. The requirements for activation are identical to those needed for the hyd
Publikováno v:
Proceedings of the National Academy of Sciences. 71:3019-3023
Collagen synthesis is increased in the aortas, mesenteric arteries, and to a lesser extent, in the hearts of rats either made hypertensive with desoxycorticosterone acetate-salt or that are spontaneously hypertensive. Several markers of collagen bios
Publikováno v:
Biochemical and Biophysical Research Communications. 43:537-543
The sequential copolymer (Pro-Gly-Pro)∼12 was hydroxylated in an 18O2 atmosphere with a partially purified preparation of collagen proline hydroxylase. Mass spectral analysis demonstrated the incorporation of one atom of 18O into hydroxyproline and
Publikováno v:
Journal of Biological Chemistry. 245:3771-3775
We have proposed that the accumulation of methylmalonyl-CoA, which occurs when a deficiency of B12 coenzyme exists, may lead to its incorporation into fatty acids in place of malonyl-CoA. This lead to the production of fatty acids, which are not usua