Zobrazeno 1 - 10
of 125
pro vyhledávání: '"George J Murphy"'
Autor:
Dmitry A. Kretov, Leighton Folkes, Alexandra Mora-Martin, Isha A. Walawalkar, Imrat, Noreen Syedah, Kim Vanuytsel, Simon Moxon, George J. Murphy, Daniel Cifuentes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Differentiation of stem and progenitor cells is a highly regulated process that involves the coordinated action of multiple layers of regulation. Here we show how the post-transcriptional regulatory layer instructs the level of chromatin reg
Externí odkaz:
https://doaj.org/article/12c9809215524e7283c8840d491bb1be
Autor:
Alexandra B. Ysasi, Anna E. Engler, Pushpinder Singh Bawa, Feiya Wang, Regan D. Conrad, Anthony K. Yeung, Jason R. Rock, Jennifer Beane-Ebel, Sarah A. Mazzilli, Ruth A. Franklin, Joseph P. Mizgerd, George J. Murphy
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110169- (2024)
Summary: Macrophages are critical for maintenance and repair of mucosal tissues. While functionally distinct subtypes of macrophage are known to have important roles in injury response and repair in the lungs, little is known about macrophages in the
Externí odkaz:
https://doaj.org/article/5b903bda8cf440d19e820e282f3de643
Autor:
Wei Wen Teo, Xinang Cao, Chan-Shuo Wu, Hong Kee Tan, Qiling Zhou, Chong Gao, Kim Vanuytsel, Sara S. Kumar, George J. Murphy, Henry Yang, Li Chai, Daniel G. Tenen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Identification of a long non-coding RNA LEVER, that inhibits the Polycomb Repressive Complex 2 (PRC2) and controls nearby embryonic form of beta-globin gene, provides additional evidence for PRC2-RNA functional interaction.
Externí odkaz:
https://doaj.org/article/c0033e53f61b43739e86a5b844cef74f
Autor:
Kim Vanuytsel, Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, Zhe Wang, Wilfredo F. Garcia-Beltran, Vladimir Vrbanac, Dylan Parsons, Evan C. Lam, Taylor M. Matte, Todd W. Dowrey, Sara S. Kumar, Mengze Li, Feiya Wang, Anthony K. Yeung, Gustavo Mostoslavsky, Ruben Dries, Joshua D. Campbell, Anna C. Belkina, Alejandro B. Balazs, George J. Murphy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
During human embryonic development, haematopoietic stem cells of the foetal liver undergo expansion, while retaining engraftment capacity. Here the authors apply CITE-seq to profile single cells from a human foetal liver, identifying a molecular sign
Externí odkaz:
https://doaj.org/article/cac11a57fa10405ca22f6fddb6df2365
Autor:
Richard M. Giadone, Aditya Mithal, Gregory J. Miller, Taylor M. Matte, Anthony K. Yeung, Todd W. Dowrey, Rhiannon B. Werder, Nancy S. Miller, Christopher D. Andry, Kim Vanuytsel, George J. Murphy
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100102- (2020)
Summary: The protocols herein outline the use of qRT-PCR to detect the presence of SARS-CoV-2 genomic RNA in patient samples. In order to cope with potential fluctuations in supply chain and testing demands and to enable expedient adaptation of reage
Externí odkaz:
https://doaj.org/article/3349c7abf4194e76929334350de84a55
Autor:
Kim Vanuytsel, Taylor Matte, Amy Leung, Zaw Htut Naing, Tasha Morrison, David H.K. Chui, Martin H. Steinberg, George J. Murphy
Publikováno v:
Blood Advances, Vol 2, Iss 15, Pp 1998-2011 (2018)
Abstract: Robust β-globin expression in erythroid cells derived from induced pluripotent stem cells (iPSCs) increases the resolution with which red blood cell disorders such as sickle cell disease and β thalassemia can be modeled in vitro. To bette
Externí odkaz:
https://doaj.org/article/90f65c6905b545d187d63ae96104ade0
Autor:
Elmutaz M. Shaikho, John J. Farrell, Abdulrahman Alsultan, Hatem Qutub, Amein K. Al-Ali, Maria Stella Figueiredo, David H.K. Chui, Lindsay A. Farrer, George J. Murphy, Gustavo Mostoslavsky, Paola Sebastiani, Martin H. Steinberg
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-7 (2017)
Abstract Background Sickle cell anemia causes severe complications and premature death. Five common β-globin gene cluster haplotypes are each associated with characteristic fetal hemoglobin (HbF) levels. As HbF is the major modulator of disease seve
Externí odkaz:
https://doaj.org/article/6916a1fd4f2f428e9450ecfe0629af1c
Autor:
Peter E. A. Ash, Elizabeth A. Stanford, Ali Al Abdulatif, Alejandra Ramirez-Cardenas, Heather I. Ballance, Samantha Boudeau, Amanda Jeh, James M. Murithi, Yorghos Tripodis, George J. Murphy, David H. Sherr, Benjamin Wolozin
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-14 (2017)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative condition that is characterized by progressive loss of motor neurons and the accumulation of aggregated TAR DNA Binding Protein-43 (TDP-43, gene: TARDBP). Inc
Externí odkaz:
https://doaj.org/article/918a0164aa8e4ba8b9e5f89dd64cfaf5
Autor:
Seonmi Park, Andreia Gianotti-Sommer, Francisco Javier Molina-Estevez, Kim Vanuytsel, Nick Skvir, Amy Leung, Sarah S. Rozelle, Elmutaz Mohammed Shaikho, Isabelle Weir, Zhihua Jiang, Hong-Yuan Luo, David H.K. Chui, Maria Stella Figueiredo, Abdulraham Alsultan, Amein Al-Ali, Paola Sebastiani, Martin H. Steinberg, Gustavo Mostoslavsky, George J. Murphy
Publikováno v:
Stem Cell Reports, Vol 8, Iss 4, Pp 1076-1085 (2017)
Summary: Sickle cell anemia affects millions of people worldwide and is an emerging global health burden. As part of a large NIH-funded NextGen Consortium, we generated a diverse, comprehensive, and fully characterized library of sickle-cell-disease-
Externí odkaz:
https://doaj.org/article/52d22f01919b4214b5dcc432e367860c
Autor:
Yanan Sun, Alawi Habara, Cuong Quang Le, Nicole Nguyen, Raymon Chen, George J. Murphy, David H. K. Chui, Martin H. Steinberg, Shuaiying Cui
Publikováno v:
British Journal of Haematology. 197:97-109
Sickle cell disease (SCD) is a genetic disorder that affects millions around the world. Enhancement of fetal γ-globin levels and fetal haemoglobin (HbF) production in SCD patients leads to diminished severity of many clinical features of the disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5c0b8fbb721169cb8ac7ae8931fef77
https://doi.org/10.1111/bjh.18042
https://doi.org/10.1111/bjh.18042