Zobrazeno 1 - 10
of 68
pro vyhledávání: '"George I. Mias"'
Autor:
Minzhang Zheng, Jacqueline Charvat, Sara R. Zwart, Satish K. Mehta, Brian E. Crucian, Scott M. Smith, Jin He, Carlo Piermarocchi, George I. Mias
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
From the early days of spaceflight to current missions, astronauts continue to be exposed to multiple hazards that affect human health, including low gravity, high radiation, isolation during long-duration missions, a closed environment and distance
Externí odkaz:
https://doaj.org/article/501f4065ebfa4965ac8316afab332fac
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Longitudinal deep multiomics profiling, which combines biomolecular, physiological, environmental and clinical measures data, shows great promise for precision health. However, integrating and understanding the complexity of such data remain
Externí odkaz:
https://doaj.org/article/21d48fbcc4d04cf29fe3880213e894df
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Differential Network (DN) analysis is a method that has long been used to interpret changes in gene expression data and provide biological insights. The method identifies the rewiring of gene networks in response to external perturbations. Our study
Externí odkaz:
https://doaj.org/article/9fd4a37e3a9d4ac48e87aec347f45367
Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors
Autor:
Yuen Gao, Natalia Duque-Wilckens, Mohammad B. Aljazi, Yan Wu, Adam J. Moeser, George I. Mias, Alfred J. Robison, Jin He
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Yuen Gao et al. characterize deficits in brain morphology, behavior, and gene expression following genetic ablation of the histone methyltransferase, ASH1L, during brain development in mice. Their results provide new insight into links between ASH1L
Externí odkaz:
https://doaj.org/article/4b96d495f04d482b9a52d8c90fd24875
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Temporal behavior is an essential aspect of all biological systems. Time series have been previously represented as networks. Such representations must address two fundamental problems on how to: (1) Create appropriate networks to reflect th
Externí odkaz:
https://doaj.org/article/2c08f73c35eb45f3b17000910fce8cbc
Autor:
George I. Mias, Vikas Vikram Singh, Lavida R. K. Rogers, Shuyue Xue, Minzhang Zheng, Sergii Domanskyi, Masamitsu Kanada, Carlo Piermarocchi, Jin He
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Saliva omics has immense potential for non-invasive diagnostics, including monitoring very young or elderly populations, or individuals in remote locations. In this study, multiple saliva omics from an individual were monitored over three pe
Externí odkaz:
https://doaj.org/article/8b6200b97e7344768922bedde90265da
Autor:
Yuen Gao, Natalia Duque-Wilckens, Mohammad B. Aljazi, Adam J. Moeser, George I. Mias, Alfred J. Robison, Yi Zhang, Jin He
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103742- (2022)
Summary: Recent clinical studies report that chromosomal 12q24.31 microdeletions are associated with autism spectrum disorder (ASD) and intellectual disability (ID). However, the causality and underlying mechanisms linking 12q24.31 microdeletions to
Externí odkaz:
https://doaj.org/article/7c4859cbe5774588b7eece70ffe4b2db
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
ASH1L and MLL1 are two histone methyltransferases that facilitate transcriptional activation during normal development. However, the roles of ASH1L and its enzymatic activity in the development of MLL-rearranged leukemias are not fully elucidated in
Externí odkaz:
https://doaj.org/article/ff04978537104c5eb6767b82a4d152e3
Autor:
Raeuf Roushangar, George I. Mias
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Abstract In 2019 it is estimated that more than 21,000 new acute myeloid leukemia (AML) patients will be diagnosed in the United States, and nearly 11,000 are expected to die from the disease. AML is primarily diagnosed among the elderly (median 68 y
Externí odkaz:
https://doaj.org/article/17ac5cb8665d4ced9efa8418e66cfea6
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101646- (2020)
Summary: The recruitment of Polycomb repressive complex 2 (PRC2) to gene promoters is critical for its function in repressing gene expression in murine embryonic stem cells (mESCs). However, previous studies have demonstrated that although the expres
Externí odkaz:
https://doaj.org/article/089e6546757d467c8fb3fcfd2aacc0d1