Zobrazeno 1 - 10
of 90
pro vyhledávání: '"George I. Henderson"'
Autor:
Sambantham Shanmugam, Dhyanesh Patel, John M. Wolpert, Caezaan Keshvani, Xiaobo Liu, Susan E. Bergeson, Srivatsan Kidambi, Lenin Mahimainathan, George I. Henderson, Madhusudhanan Narasimhan
Publikováno v:
Biomolecules, Vol 9, Iss 11, p 669 (2019)
NRF2 is a redox-sensitive transcription factor that depending on the duration or magnitude of the stress, either translocates to the nucleus (beneficial) or is degraded in the cytosol (harmful). However, the role of NRF2-based mechanism(s) under etha
Externí odkaz:
https://doaj.org/article/37860d5c05a846c6a9dd7ab5bb612b75
Autor:
Louis E. Ridgway III, Thomas S. King, George I. Henderson, Steven Schenker, Robert S. Schenken
Publikováno v:
Infectious Diseases in Obstetrics and Gynecology, Vol 1, Iss 3, Pp 137-143 (1993)
Objective: This study was undertaken to characterize the pharmacokinetics of zidovudine (ZDV) and ZDV-glucuronide (ZDVG) in the material and:fetal circulations of the rhesus monkey.
Externí odkaz:
https://doaj.org/article/4044a374e4a34f19b34a8c67e927699f
Autor:
Susan E. Bergeson, Madhusudhanan Narasimhan, Sambantham Shanmugam, Dhyanesh Patel, Srivatsan Kidambi, George I. Henderson, John M Wolpert, Lenin Mahimainathan, Xiaobo Liu, Caezaan Keshvani
Publikováno v:
Biomolecules
Biomolecules, Vol 9, Iss 11, p 669 (2019)
Biomolecules; Volume 9; Issue 11; Pages: 669
Biomolecules, Vol 9, Iss 11, p 669 (2019)
Biomolecules; Volume 9; Issue 11; Pages: 669
NRF2 is a redox-sensitive transcription factor that depending on the duration or magnitude of the stress, either translocates to the nucleus (beneficial) or is degraded in the cytosol (harmful). However, the role of NRF2-based mechanism(s) under etha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e462f5f61746c58acbcf19fb56605e
http://europepmc.org/articles/PMC6921053
http://europepmc.org/articles/PMC6921053
Autor:
Lenin Mahimainathan, Dhanashree Vedpathak, George I. Henderson, Amanjot Kaur Riar, Mary Latha Rathinam, Madhusudhanan Narasimhan
Publikováno v:
Toxicology Letters. 228:179-191
Epidemiological and animal studies suggest that environmental toxins including paraquat (PQ) increase the risk of developing Parkinson's disease (PD) by damaging nigrostriatal dopaminergic neurons. We previously showed that overexpression of a group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22cadb66fdf9b5cfbb8d040f7446604c
https://doi.org/10.1016/j.toxlet.2014.05.020
https://doi.org/10.1016/j.toxlet.2014.05.020
Autor:
Ruin Moaddel, Marisela Dagda, Aveline Hewetson, Susan E. Bergeson, George I. Henderson, Mitesh Sanghvi, Inna I. Kruman, Anna Kate Fowler, Yukun Chen, Rajiv G. Agrawal, Silvia Balbo, Raul Y. Dagda, Ryan J. Hogue
Publikováno v:
Journal of Biological Chemistry. 287:43533-43542
The brain is one of the major targets of chronic alcohol abuse. Yet the fundamental mechanisms underlying alcohol-mediated brain damage remain unclear. The products of alcohol metabolism cause DNA damage, which in conditions of DNA repair dysfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d42746abfad40f9c8100ee7959c397
https://doi.org/10.1074/jbc.m112.401497
https://doi.org/10.1074/jbc.m112.401497
Autor:
George I. Henderson, Mary Latha Rathinam, Amanjot Kaur Riar, Lenin Mahimainathan, Madhusudhanan Narasimhan
Publikováno v:
Journal of Biomedical Science
Background Developing brain is a major target for alcohol’s actions and neurological/functional abnormalities include microencephaly, reduced frontal cortex, mental retardation and attention-deficits. Previous studies have shown that ethanol altere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4331fb097c3067e5102f2f6d1795f275
https://doi.org/10.1186/s12929-016-0225-8
https://doi.org/10.1186/s12929-016-0225-8
Publikováno v:
Experimental Biology and Medicine. 237:740-747
Chronic alcohol abuse results in a variety of pathological effects including damage to the brain. The causes of alcohol-induced brain pathology are presently unclear. Several mechanisms of pathogenicity of chronic alcoholism have been proposed, inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93123c2a02eba20fb8b6c77ce0435936
https://doi.org/10.1258/ebm.2012.011421
https://doi.org/10.1258/ebm.2012.011421
Astrocytes Prevent Ethanol Induced Apoptosis of Nrf2 Depleted Neurons by Maintaining GSH Homeostasis
Autor:
Lenin Mahimainathan, Marylatha Rathinam, Madhusudhanan Narasimhan, George I. Henderson, Dhyanesh Patel
Publikováno v:
Open Journal of Apoptosis. :9-18
Glutathione (GSH), a major cellular antioxidant protects cells against oxidative stress injury. Nuclear factor erythroid 2-related factor 2 (NFE2L2/Nrf2) is a redox sensitive master regulator of battery of antioxidant enzymes including those involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4cde0aee4f97afc18759db578383ec1
https://doi.org/10.4236/ojapo.2012.12002
https://doi.org/10.4236/ojapo.2012.12002
Role for Cystathionine γ Lyase (CSE) in an Ethanol (E)-Induced Lesion in Fetal Brain GSH Homeostasis
Autor:
Madhusudhanan Narasimhan, George I. Henderson, Courtney Jarvis, Lenin Mahimainathan, Dhyanesh Patel, Marylatha Rathinam
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 19; Issue 5; Pages: 1537
International Journal of Molecular Sciences; Volume 19; Issue 5; Pages: 1537
Earlier, we reported that gestational ethanol (E) can dysregulate neuron glutathione (GSH) homeostasis partially via impairing the EAAC1-mediated inward transport of Cysteine (Cys) and this can affect fetal brain development. In this study, we invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b20a27e8235ab99bdc42cedd50e6950
https://doi.org/10.3390/ijms19051537
https://doi.org/10.3390/ijms19051537
Autor:
Marylatha Rathinam, Madhusudhanan Narasimhan, George I. Henderson, Dhyanesh Patel, Lenin Mahimainathan
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2596
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2596 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2596
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2596 (2017)
Central among the fetotoxic responses to in utero ethanol (E) exposure is redox-shift related glutathione (GSH) loss and apoptosis. Previously, we reported that despite an E-generated Nrf2 upregulation, fetal neurons still succumb. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d463155f2f8e1e233de22db874de08f
https://doi.org/10.3390/ijms18122596
https://doi.org/10.3390/ijms18122596