Zobrazeno 1 - 10 of 40 pro vyhledávání: '"George I. Birnbaum"'
1
1.70 Å resolution structure of myoglobin from yellowfin tuna. An example of a myoglobin lacking the D helix
Autor: S.V. Evans, Maria Przybylska, George I. Birnbaum, D.R. Rose
Publikováno v: Acta Crystallographica Section D Biological Crystallography. 50:283-289
The crystal structure of metmyoglobin from yellowfin tuna (Thunnus albacares) has been determined by molecular replacement methods and refined to a conventional R factor of 0.177 for all observed reflections in the range of 6.0-1.70 A resolution. Lik
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8468a8be4e7209b676e3e1893501605
https://doi.org/10.1107/s0907444993014271
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2
Fine-tuned conformation of dithioacylpapain intermediates: insights from resonance Raman spectroscopy
Autor: Paul R. Carey, George I. Birnbaum, Rosemary C. Hynes, Munsok Kim, Witold Neugebauer
Publikováno v: Journal of the American Chemical Society. 115:6230-6237
Interpretation of the resonance Raman (RR) spectrum of functioning N-benzoylglycine dithioacylpapain, (C 6 H 5 C(=O)NHCH 2 C(=S)SCH 2 -papain) provides an estimate of four torsion angles near the point of catalytic attack. The torsion angles CN-CC, N
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c832b3a32d71d33792b9c18287ac1435
https://doi.org/10.1021/ja00067a042
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5
Structure and Conformation of 5′-Chlorocyclocytidine, a Potent Inhibitor of Nucleic Acid Synthesis: X-Ray,1H and13C NMR Analyses
Autor: George I. Birnbaum, Miloś Budéšínsk, Ladislav Novotn
Publikováno v: Nucleosides and Nucleotides. 10:1625-1640
The structure of the hydrochloride of 5′-chlorocyclocytidine, a potent inhibitor of DNA synthesis, was determined by X-ray crystallography. The nucleoside crystallizes in the orthorhombic space group P212121 with cell dimensions a = 10.413(4), b =
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fa348bd644c30c48dd64285356fc5e0
https://doi.org/10.1080/15257779108043050
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6
Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogs, and crystal structure of 1-(3-deoxy-.beta.-D-threo-pentofuranosyl)cytosine
Autor: Shen Zy, I. Ghazzouli, J. Giziewicz, Mao-Chin Liu, George I. Birnbaum, J.‐H. Yang, Brankovan, Yung-Chi Cheng, Tai-Shun Lin, William H. Prusoff
Publikováno v: Journal of Medicinal Chemistry. 34:693-701
Various 3'-deoxy pyrimidine nucleoside analogues have been synthesized for evaluation as potential anticancer and antiviral agents. Among these compounds, 1-(3-deoxy-beta-D-threo-pentofuranosyl)cytosine (10, 3'-deoxy-ara-C) and 3'-deoxycytidine (22)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e394b89472d05c555601dced5b401ca7
https://doi.org/10.1021/jm00106a034
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7
Synthesis of L-Iduronic Acid Derivatives: Crystal Structure of Methyl (Methyl 2,3,4-Tri-O-Acetyl-β-L-Idopyranosid)Uronate
Autor: Henrianna Pang, Dennis M. Whitfield, Bibudhendra Sarkar, George I. Birnbaum, Jose Baptista
Publikováno v: Journal of Carbohydrate Chemistry. 10:329-348
Several L-iduronic acid derivatives were prepared by chemical synthesis including the reducing sugar, the α– and s-methyl glycosides and L-iduronolactone. The s-methyl glycoside, as well as two isomeric orthoesters, were the unexpected products of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::517f4fc72df622f191c8f13d318d4e5a
https://doi.org/10.1080/07328309108543912
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8
Structure of oncomodulin refined at 1·85 Å resolution
Autor: John P. MacManus, Farid R. Ahmed, George I. Birnbaum, David R. Rose, Maria Przybylska, Margaret E. Pippy
Publikováno v: Journal of Molecular Biology. 216:127-140
The crystal structure of oncomodulin, a 12,000 Mr protein isolated from rat tumours, has been determined by molecular replacement using the carp parvalbumin structure as a starting model. Refinement was performed by cycles of molecular fitting and re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f5f998f03612ad99dcb668aac8e7d3a
https://doi.org/10.1016/s0022-2836(05)80065-8
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9
Experiments in microgravity: a comparison of crystals of a carbohydrate-binding fab grown on the ground, on space shuttle Discovery and on space station Mir
Autor: S.V. Evans, D.R. Rose, George I. Birnbaum, S.N. Borisova
Publikováno v: Acta crystallographica. Section D, Biological crystallography. 52(Pt 2)
The Fab fragment of the hybridoma antibody (YsT9.1) specific to Brucella abortus has been crystallized on earth using both Linbro plates and ground-based models of the flight hardware, as well as in microgravity on board the space shuttle Discovery a
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https://pubmed.ncbi.nlm.nih.gov/15299699
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10
Synthesis and anticancer and antiviral activities of various 2'- and 3'-methylidene-substituted nucleoside analogues and crystal structure of 2'-deoxy-2'-methylidenecytidine hydrochloride
Autor: Tai Shun Lin, Yung-Chi Cheng, Eric J. Gabe, M.‐C. Liu, Regina H. Clarke-Katzenburg, J. Giziewicz, Mei Zhen Luo, William R. Mancini, William H. Prusoff, George I. Birnbaum
Publikováno v: Journal of medicinal chemistry. 34(8)
Various 2'- and 3'-methylidene-substituted nucleoside analogues have been synthesized and evaluated as potential anticancer and/or antiviral agents. Among these compounds, 2'-deoxy-2'-methylidene-5-fluorocytidine (22) and 2'-deoxy-2'-methylidenecytid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3872a61547d6ebb668ba8fbb95b00548
https://pubmed.ncbi.nlm.nih.gov/1652024
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