Zobrazeno 1 - 10
of 162
pro vyhledávání: '"George I, Makhatadze"'
Publikováno v:
Biophysical Journal. 121:4892-4899
High hydrostatic pressure can have profound effects on the stability of biomacromolecules. The magnitude and direction (stabilizing or destabilizing) of this effect is defined by the volume changes in the system, ΔV. Positive volume changes will sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66bd76b6fb2a8cbf9103cedb767ad07
https://doi.org/10.1016/j.bpj.2022.08.005
https://doi.org/10.1016/j.bpj.2022.08.005
Autor:
Calvin R. Chen, George I. Makhatadze
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Proteins can be both stabilized and destabilized by pressure. Here the authors analyse the factors contributing to both negative and positive protein volume change upon denaturation, and shed light on the molecular determinants allowing proteins to b
Externí odkaz:
https://doaj.org/article/50911fbe0db5457e8947f0045802ad5f
Autor:
Samvel Avagyan, George I. Makhatadze
Publikováno v:
The journal of physical chemistry. B. 126(39)
Understanding how high hydrostatic pressure affects biomacromolecular interaction is important for deciphering the molecular mechanisms by which organisms adapt to live at the bottom of the ocean. The relative effect of hydrostatic pressure on the ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c708d48112c88f89c31a116d283e0b6
https://pubmed.ncbi.nlm.nih.gov/36150186
https://pubmed.ncbi.nlm.nih.gov/36150186
Autor:
Surya V. S. R. K. Pulavarti, Jack B. Maguire, Shirley Yuen, Joseph S. Harrison, Jermel Griffin, Lakshmanane Premkumar, Edward A. Esposito, George I. Makhatadze, Angel E. Garcia, Thomas M. Weiss, Edward H. Snell, Brian Kuhlman, Thomas Szyperski
Publikováno v:
The journal of physical chemistry. B. 126(6)
Understanding protein folding is crucial for protein sciences. The conformational spaces and energy landscapes of cold (unfolded) protein states, as well as the associated transitions, are hardly explored. Furthermore, it is not known how structure r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45cc676019c22a97458f9aba199032ba
https://pubmed.ncbi.nlm.nih.gov/35128921
https://pubmed.ncbi.nlm.nih.gov/35128921
Autor:
Hina Iqbal, Ka Wai Fung, Jayesh Gor, Anthony C. Bishop, George I. Makhatadze, Barbara Brodsky, Stephen J. Perkins
Publikováno v:
Journal of Biological Chemistry. 299:102799
Collagen triple helices are critical in the function of mannan-binding lectin (MBL), an oligomeric recognition molecule in complement activation. The MBL collagen regions form complexes with the serine proteases MASP-1 and MASP-2 in order to activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237bd10a70036a5e97c63a0803b07439
https://doi.org/10.1016/j.jbc.2022.102799
https://doi.org/10.1016/j.jbc.2022.102799
Autor:
George I. Makhatadze
Publikováno v:
Biophysical Journal. 122:466a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fd04afeebcede053205648d265ec121
https://doi.org/10.1016/j.bpj.2022.11.2500
https://doi.org/10.1016/j.bpj.2022.11.2500
Autor:
Samvel Avagyan, George I. Makhatadze
Publikováno v:
Biochemistry. 60(41)
Understanding the thermodynamic mechanisms of adaptation of biomacromolecules to high hydrostatic pressure can help shed light on how piezophilic organisms can survive at pressures reaching over 1000 atmospheres. Interaction of proteins with nucleic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7cd354b2e54e76f6e1ca5da050456e
https://pubmed.ncbi.nlm.nih.gov/34613715
https://pubmed.ncbi.nlm.nih.gov/34613715
Autor:
Samvel Avagyan, George I. Makhatadze
Hydrostatic pressure together with the temperature is an important environmental variable that plays an essential role in biological adaptation of extremophilic organisms. In particular, the effects of hy-drostatic pressure on the rates of the protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14f52c2d7c6bf59342e23a1af6442bd0
https://doi.org/10.33774/chemrxiv-2021-svw4f
https://doi.org/10.33774/chemrxiv-2021-svw4f
Autor:
Catherine A. Royer, Amanda S. Byer, Nozomi Ando, Richard E. Gillilan, Blanca Barquera, Eric S. Boyd, Martin Gruebele, Everett L. Shock, George I. Makhatadze, Daniel R. Colman, A. Joshua Wand, Douglas H. Bartlett, Audrey A. Burnim, Maxwell B. Watkins
Publikováno v:
Annual review of biophysics. 50
Sampling and genomic efforts over the past decade have revealed an enormous quantity and diversity of life in Earth's extreme environments. This new knowledge of life on Earth poses the challenge of understandingits molecular basis in such inhospitab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a72dd996abdec5bdc15b1e36398436c
https://pubmed.ncbi.nlm.nih.gov/33637008
https://pubmed.ncbi.nlm.nih.gov/33637008
Autor:
Scott A. McCallum, Anthony C. Bishop, Nadia R. Roan, Sherry C S Xu, George I. Makhatadze, Welby H Huynh, Nathan A James, Josephine G. LoRicco
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 36
Cnidarian fluorescent protein (FP) derivatives such as GFP, mCherry, and mEOS2 have been widely used to monitor gene expression and protein localization through biological imaging because they are considered functionally inert. We demonstrate that FP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e42b7a834a63a6b2f0bf1a45aad0165
https://escholarship.org/uc/item/6rh6d0br
https://escholarship.org/uc/item/6rh6d0br