Zobrazeno 1 - 10
of 420
pro vyhledávání: '"George Hripcsak"'
Autor:
Tiffany J. Callahan, Ignacio J. Tripodi, Adrianne L. Stefanski, Luca Cappelletti, Sanya B. Taneja, Jordan M. Wyrwa, Elena Casiraghi, Nicolas A. Matentzoglu, Justin Reese, Jonathan C. Silverstein, Charles Tapley Hoyt, Richard D. Boyce, Scott A. Malec, Deepak R. Unni, Marcin P. Joachimiak, Peter N. Robinson, Christopher J. Mungall, Emanuele Cavalleri, Tommaso Fontana, Giorgio Valentini, Marco Mesiti, Lucas A. Gillenwater, Brook Santangelo, Nicole A. Vasilevsky, Robert Hoehndorf, Tellen D. Bennett, Patrick B. Ryan, George Hripcsak, Michael G. Kahn, Michael Bada, William A. Baumgartner, Lawrence E. Hunter
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-22 (2024)
Abstract Translational research requires data at multiple scales of biological organization. Advancements in sequencing and multi-omics technologies have increased the availability of these data, but researchers face significant integration challenge
Externí odkaz:
https://doaj.org/article/2ba11bcf971c40478fb1f6a852218703
Publikováno v:
The Journal of Clinical Hypertension, Vol 26, Iss 4, Pp 425-430 (2024)
Abstract Previous work comparing safety and effectiveness outcomes for new initiators of angiotensin converting‐enzyme inhibitors (ACEi) and thiazides demonstrated more favorable outcomes for thiazides, although cohort definitions allowed for addit
Externí odkaz:
https://doaj.org/article/892a54bc6ddf4f01b5ac1b272fa72841
Autor:
Melike Sirlanci, George Hripcsak, Cecilia C. Low Wang, J. N. Stroh, Yanran Wang, Tellen D. Bennett, Andrew M. Stuart, David J. Albers
Publikováno v:
Frontiers in Medical Engineering, Vol 2 (2024)
Introduction: Intensive care unit (ICU) patients exhibit erratic blood glucose (BG) fluctuations, including hypoglycemic and hyperglycemic episodes, and require exogenous insulin delivery to keep their BG in healthy ranges. Glycemic control via glyce
Externí odkaz:
https://doaj.org/article/edb0a3da38e34bb3b96a523dc26ce616
Autor:
Atlas Khan, Ning Shang, Jordan G. Nestor, Chunhua Weng, George Hripcsak, Peter C. Harris, Ali G. Gharavi, Krzysztof Kiryluk
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Chronic kidney disease (CKD) is determined by an interplay of monogenic, polygenic, and environmental risks. Autosomal dominant polycystic kidney disease (ADPKD) and COL4A-associated nephropathy (COL4A-AN) represent the most common forms of
Externí odkaz:
https://doaj.org/article/675519d846a343a897e38aab1289ae9c
Autor:
Tiffany J. Callahan, Adrianne L. Stefanski, Jordan M. Wyrwa, Chenjie Zeng, Anna Ostropolets, Juan M. Banda, William A. Baumgartner, Richard D. Boyce, Elena Casiraghi, Ben D. Coleman, Janine H. Collins, Sara J. Deakyne Davies, James A. Feinstein, Asiyah Y. Lin, Blake Martin, Nicolas A. Matentzoglu, Daniella Meeker, Justin Reese, Jessica Sinclair, Sanya B. Taneja, Katy E. Trinkley, Nicole A. Vasilevsky, Andrew E. Williams, Xingmin A. Zhang, Joshua C. Denny, Patrick B. Ryan, George Hripcsak, Tellen D. Bennett, Melissa A. Haendel, Peter N. Robinson, Lawrence E. Hunter, Michael G. Kahn
Publikováno v:
npj Digital Medicine, Vol 6, Iss 1, Pp 1-18 (2023)
Abstract Common data models solve many challenges of standardizing electronic health record (EHR) data but are unable to semantically integrate all of the resources needed for deep phenotyping. Open Biological and Biomedical Ontology (OBO) Foundry on
Externí odkaz:
https://doaj.org/article/19e71d5e4d104d89b86f312e42ae7202
Autor:
Lili Liu, Atlas Khan, Elena Sanchez-Rodriguez, Francesca Zanoni, Yifu Li, Nicholas Steers, Olivia Balderes, Junying Zhang, Priya Krithivasan, Robert A. LeDesma, Clara Fischman, Scott J. Hebbring, John B. Harley, Halima Moncrieffe, Leah C. Kottyan, Bahram Namjou-Khales, Theresa L. Walunas, Rachel Knevel, Soumya Raychaudhuri, Elizabeth W. Karlson, Joshua C. Denny, Ian B. Stanaway, David Crosslin, Thomas Rauen, Jürgen Floege, Frank Eitner, Zina Moldoveanu, Colin Reily, Barbora Knoppova, Stacy Hall, Justin T. Sheff, Bruce A. Julian, Robert J. Wyatt, Hitoshi Suzuki, Jingyuan Xie, Nan Chen, Xujie Zhou, Hong Zhang, Lennart Hammarström, Alexander Viktorin, Patrik K. E. Magnusson, Ning Shang, George Hripcsak, Chunhua Weng, Tatjana Rundek, Mitchell S. V. Elkind, Elizabeth C. Oelsner, R. Graham Barr, Iuliana Ionita-Laza, Jan Novak, Ali G. Gharavi, Krzysztof Kiryluk
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Immunoglobulin A protects against infectious disease and contributes to autoimmune and inflammatory disorders. Here, the authors perform a genome-wide association study for serum IgA levels, identifying 20 genome-wide significant loci, providing new
Externí odkaz:
https://doaj.org/article/a56e340c9bb948a69e4eb08fc8a4c941
Autor:
Rohan Khera, Yuan Lu, Michael E Matheny, Kenneth KC Man, Paul Nagy, Nigam Shah, Martijn J Schuemie, Scott L DuVall, Seng Chan You, Jose D Posada, George Hripcsak, Marc A Suchard, Patrick B Ryan, Anna Ostropolets, Evan Minty, Clair Blacketer, Arya Aminorroaya, Thomas Falconer, Nestoras Mathioudakis, Jin J Zhou, Can Yin, Kelly Li, Lovedeep Singh Dhingra, Faaizah Arshad, Mary G Bowring, Fan Bu, David A Dorr, Tina E French, Elizabeth E Hanchrow, Scott Horban, Wallis CY Lau, Yuntian Liu, Michael F McLemore, Akihiko Nishimura, Sarah Seager, Eric YF Wan, Jianxiao Yang
Publikováno v:
BMJ Medicine, Vol 2, Iss 1 (2023)
Objective To assess the uptake of second line antihyperglycaemic drugs among patients with type 2 diabetes mellitus who are receiving metformin.Design Federated pharmacoepidemiological evaluation in LEGEND-T2DM.Setting 10 US and seven non-US electron
Externí odkaz:
https://doaj.org/article/cd277362d5684feaa32b34690f64437c
Autor:
Erica A. Voss, Azza Shoaibi, Lana Yin Hui Lai, Clair Blacketer, Thamir Alshammari, Rupa Makadia, Kevin Haynes, Anthony G. Sena, Gowtham Rao, Sebastiaan van Sandijk, Clement Fraboulet, Laurent Boyer, Tanguy Le Carrour, Scott Horban, Daniel R. Morales, Jordi Martínez Roldán, Juan Manuel Ramírez-Anguita, Miguel A. Mayer, Marcel de Wilde, Luis H. John, Talita Duarte-Salles, Elena Roel, Andrea Pistillo, Raivo Kolde, Filip Maljković, Spiros Denaxas, Vaclav Papez, Michael G. Kahn, Karthik Natarajan, Christian Reich, Alex Secora, Evan P. Minty, Nigam H. Shah, Jose D. Posada, Maria Teresa Garcia Morales, Diego Bosca, Honorio Cadenas Juanino, Antonio Diaz Holgado, Miguel Pedrera Jiménez, Pablo Serrano Balazote, Noelia García Barrio, Selçuk Şen, Ali Yağız Üresin, Baris Erdogan, Luc Belmans, Geert Byttebier, Manu L.N.G. Malbrain, Daniel J. Dedman, Zara Cuccu, Rohit Vashisht, Atul J. Butte, Ayan Patel, Lisa Dahm, Cora Han, Fan Bu, Faaizah Arshad, Anna Ostropolets, Fredrik Nyberg, George Hripcsak, Marc A. Suchard, Dani Prieto-Alhambra, Peter R. Rijnbeek, Martijn J. Schuemie, Patrick B. Ryan
Publikováno v:
EClinicalMedicine, Vol 58, Iss , Pp 101932- (2023)
Summary: Background: Adverse events of special interest (AESIs) were pre-specified to be monitored for the COVID-19 vaccines. Some AESIs are not only associated with the vaccines, but with COVID-19. Our aim was to characterise the incidence rates of
Externí odkaz:
https://doaj.org/article/699e462100af44ad885c8109c6df5465
Autor:
Betina Idnay, Yilu Fang, Alex Butler, Joyce Moran, Ziran Li, Junghwan Lee, Casey Ta, Cong Liu, Chi Yuan, Huanyao Chen, Edward Stanley, George Hripcsak, Elaine Larson, Karen Marder, Wendy Chung, Brenda Ruotolo, Chunhua Weng
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
Abstract Background: Randomized clinical trials (RCT) are the foundation for medical advances, but participant recruitment remains a persistent barrier to their success. This retrospective data analysis aims to (1) identify clinical trial features a
Externí odkaz:
https://doaj.org/article/4380736b6103418dbdb03affab828b78
Autor:
Daniel Prieto-Alhambra, Talita Duarte-Sales, Heba Alghoul, Thamir M Alshammari, Clair Blacketer, Waheed-Ul-Rahman Ahmed, Lana Lai, Scott DuVall, Fredrik Nyberg, Michael Matheny, Peter Rijnbeek, Jose Posada, Anthony Sena, Matthew Spotnitz, Seng Chan You, Marc Suchard, Patrick Ryan, George Hripcsak, Daniel Morales, Nigam Shah, Katia Verhamme, David Moreno-Martos, Kristin Kostka, Anna Ostropolets
Publikováno v:
Wellcome Open Research, Vol 7 (2023)
Background: Characterization studies of COVID-19 patients with chronic obstructive pulmonary disease (COPD) are limited in size and scope. The aim of the study is to provide a large-scale characterization of COVID-19 patients with COPD. Methods: We i
Externí odkaz:
https://doaj.org/article/3c24b0f8be2844f7aada5972f77a7245